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Multidrug Resistance Proteins (MRPs) and Cancer Therapy

The AAPS journal, 2015-04, Vol.17 (4), p.802-812

2015

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Structure–function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting

Nature communications, 2021-03, Vol.12 (1), p.1382-15, Article 1382

2021

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On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation

Clinical cancer research, 2019-06, Vol.25 (11), p.3341-3351

2019

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Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo

Cancer letters, 2018-06, Vol.424, p.19-29

2018

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Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer: In vitro and in vivo study

Cancer letters, 2017-06, Vol.396, p.145-154

2017

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Voruciclib, a Potent CDK4/6 Inhibitor, Antagonizes ABCB1 and ABCG2-Mediated Multi-Drug Resistance in Cancer Cells

Cellular physiology and biochemistry, 2018-01, Vol.45 (4), p.1515-1528

2018

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Regorafenib antagonizes BCRP-mediated multidrug resistance in colon cancer

Cancer letters, 2019-02, Vol.442, p.104-112

2019

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Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer

Proceedings of the National Academy of Sciences - PNAS, 2022-07, Vol.119 (30), p.e2206588119

2022

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An organoruthenium complex overcomes ABCG2-mediated multidrug resistance via multiple mechanisms

Chemical communications (Cambridge, England), 2019-03, Vol.55 (26), p.3833-3836

2019

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Theoretical study of blue‐green iridium(III) complexes with low‐efficiency roll‐off properties for application in phosphorescent organic light‐emitting diodes

Applied organometallic chemistry, 2024-02, Vol.38 (2), p.n/a

2024

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A theory study based on DFT/TD‐DFT for a series of Ir(III) complexes with the low‐efficiency roll‐off and the high‐inter‐system crossover rate properties

International journal of quantum chemistry, 2024-01, Vol.124 (1), p.n/a

2024

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In vitro, in vivo and ex vivo characterization of ibrutinib: a potent inhibitor of the efflux function of the transporter MRP1

British journal of pharmacology, 2014-12, Vol.171 (24), p.5845-5857

2014

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Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters

Scientific reports, 2016-05, Vol.6 (1), p.25694-25694, Article 25694

2016

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Theoretical study on luminescence properties of a series of iridium complexes with high spin orbit coupling coefficients

Journal of physical organic chemistry, 2023-10, Vol.36 (10)

2023

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The reversal of antineoplastic drug resistance in cancer cells by β‐elemene

Ai zheng, 2015-09, Vol.34 (3), p.1-8, Article 45

2015

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Osimertinib (AZD9291), a Mutant-Selective EGFR Inhibitor, Reverses ABCB1-Mediated Drug Resistance in Cancer Cells

Molecules (Basel, Switzerland), 2016-09, Vol.21 (9), p.1236

2016

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Editorial: Targeted cancer therapies, from small molecules to antibodies, volume II

Frontiers in pharmacology, 2023-06, Vol.14, p.1147488-1147488

2023

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The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors

Molecular cancer therapeutics, 2017-06, Vol.16 (6), p.1021-1030

2017

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Synthesis and biological evaluation of new thiazolyl-urea derivatives as potential dual C-RAF/FLT3 inhibitors

Medicinal chemistry research, 2022-11, Vol.31 (11), p.1862-1874

2022

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Lamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells

Marine drugs, 2014-06, Vol.12 (7), p.3818-3837

2014

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Repositioning of Tyrosine Kinase Inhibitors as Antagonists of ATP-Binding Cassette Transporters in Anticancer Drug Resistance

Cancers, 2014-09, Vol.6 (4), p.1925-1952

2014

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Quizartinib (AC220) reverses ABCG2-mediated multidrug resistance: In vitro and in vivo studies

Oncotarget, 2017-11, Vol.8 (55), p.93785-93799

2017

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WHI‐P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2‐overexpressing cells

Cancer science, 2014-08, Vol.105 (8), p.1071-1078

2014

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Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1

Scientific reports, 2017-02, Vol.7 (1), p.42106, Article 42106

2017

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Commissioning of a high-resolution collinear laser spectroscopy apparatus with a laser ablation ion source

Nuclear science and techniques, 2022, Vol.33 (1), p.98-106, Article 9

2022

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Multidrug Resistance Proteins (MRPs) and Cancer Therapy

Structure–function analysis of oncogenic EGFR Kinase Domain Duplication reveals insights into activation and a potential approach for therapeutic targeting

On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation

Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo

Regorafenib overcomes chemotherapeutic multidrug resistance mediated by ABCB1 transporter in colorectal cancer: In vitro and in vivo study

Voruciclib, a Potent CDK4/6 Inhibitor, Antagonizes ABCB1 and ABCG2-Mediated Multi-Drug Resistance in Cancer Cells

Regorafenib antagonizes BCRP-mediated multidrug resistance in colon cancer

Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer

An organoruthenium complex overcomes ABCG2-mediated multidrug resistance via multiple mechanisms

Theoretical study of blue‐green iridium(III) complexes with low‐efficiency roll‐off properties for application in phosphorescent organic light‐emitting diodes

A theory study based on DFT/TD‐DFT for a series of Ir(III) complexes with the low‐efficiency roll‐off and the high‐inter‐system crossover rate properties

In vitro, in vivo and ex vivo characterization of ibrutinib: a potent inhibitor of the efflux function of the transporter MRP1

Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters

Theoretical study on luminescence properties of a series of iridium complexes with high spin orbit coupling coefficients

The reversal of antineoplastic drug resistance in cancer cells by β‐elemene

Osimertinib (AZD9291), a Mutant-Selective EGFR Inhibitor, Reverses ABCB1-Mediated Drug Resistance in Cancer Cells

Editorial: Targeted cancer therapies, from small molecules to antibodies, volume II

The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors

Synthesis and biological evaluation of new thiazolyl-urea derivatives as potential dual C-RAF/FLT3 inhibitors

Lamellarin O, a pyrrole alkaloid from an Australian marine sponge, Ianthella sp., reverses BCRP mediated drug resistance in cancer cells

Repositioning of Tyrosine Kinase Inhibitors as Antagonists of ATP-Binding Cassette Transporters in Anticancer Drug Resistance

Quizartinib (AC220) reverses ABCG2-mediated multidrug resistance: In vitro and in vivo studies

WHI‐P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2‐overexpressing cells

Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1

Commissioning of a high-resolution collinear laser spectroscopy apparatus with a laser ablation ion source

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