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Two decades of research in discovery of anticancer drugs targeting STAT3, how close are we?

Pharmacology & therapeutics (Oxford), 2018-11, Vol.191, p.74-91

2018

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Cholesterol esterification inhibition and gemcitabine synergistically suppress pancreatic ductal adenocarcinoma proliferation

PloS one, 2018-02, Vol.13 (2), p.e0193318-e0193318

2018

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eIF3a regulation of mTOR signaling and translational control via HuR in cellular response to DNA damage

Oncogene, 2022-04, Vol.41 (17), p.2431-2443

2022

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Targeting survivin for therapeutic discovery: past, present, and future promises

Drug discovery today, 2017-10, Vol.22 (10), p.1466-1477

2017

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Rerouting engineered metal-dependent shapes of mesoporous silica nanocontainers to biodegradable Janus-type (sphero-ellipsoid) nanoreactors for chemodynamic therapy

Chemical engineering journal (Lausanne, Switzerland : 1996), 2019-08, Vol.370, p.1188-1199

2019

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Identification of Novel Src Inhibitors: Pharmacophore-Based Virtual Screening, Molecular Docking and Molecular Dynamics Simulations

Molecules (Basel, Switzerland), 2020-09, Vol.25 (18), p.4094

2020

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eIF3a: A new anticancer drug target in the eIF family

Cancer letters, 2018-01, Vol.412, p.81-87

2018

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Near-Infrared-Activated Lysosome Pathway Death Induced by ROS Generated from Layered Double Hydroxide-Copper Sulfide Nanocomposites

ACS applied materials & interfaces, 2020-09, Vol.12 (36), p.40673-40683

2020

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A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction

Molecular cancer therapeutics, 2008-02, Vol.7 (2), p.263-270

2008

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A Small Molecule Compound Targeting STAT3 DNA-Binding Domain Inhibits Cancer Cell Proliferation, Migration, and Invasion

ACS chemical biology, 2014-05, Vol.9 (5), p.1188-1196

2014

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14-3-3σ Contributes to Radioresistance By Regulating DNA Repair and Cell Cycle via PARP1 and CHK2

Molecular cancer research, 2017-04, Vol.15 (4), p.418-428

2017

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Novel synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth

Oncogene, 2018-05, Vol.37 (18), p.2469-2480

2018

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Dual Functional Modification of Alkaline Amino Acids Induces the Self‐Assembly of Cylinder‐Like Tobacco Mosaic Virus Coat Proteins into Gear‐Like Architectures

Small (Weinheim an der Bergstrasse, Germany), 2019-03, Vol.15 (10), p.e1805543-n/a

2019

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Proline Isomerization: From the Chemistry and Biology to Therapeutic Opportunities

Biology (Basel, Switzerland), 2023-07, Vol.12 (7), p.1008

2023

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Dual-responsive nanomotors for deep tumor penetration and subcellular arrangement

Materials & design, 2022-10, Vol.222, p.111039, Article 111039

2022

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APC Loss Prevents Doxorubicin-Induced Cell Death by Increasing Drug Efflux and a Chemoresistant Cell Population in Breast Cancer

International journal of molecular sciences, 2023-04, Vol.24 (8), p.7621

2023

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Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide production[S]

Journal of lipid research, 2013-03, Vol.54 (3), p.776-785

2013

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Dynamic vs static ABCG2 inhibitors to sensitize drug resistant cancer cells

PloS one, 2010-12, Vol.5 (12), p.e15276

2010

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Design, synthesis, and biological evaluation of 5‐(4‐(pyridin‐4‐yl)‐1H‐1,2,3‐triazol‐1‐yl)benzonitrile derivatives as xanthine oxidase inhibitors

Chemical biology & drug design, 2018-02, Vol.91 (2), p.526-533

2018

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Discovery and biological evaluation of some (1H-1,2,3-triazol-4-yl)methoxybenzaldehyde derivatives containing an anthraquinone moiety as potent xanthine oxidase inhibitors

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (4), p.729-732

2017

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Design, synthesis, and molecular docking studies of N‐(9,10‐anthraquinone‐2‐carbonyl)amino acid derivatives as xanthine oxidase inhibitors

Chemical biology & drug design, 2018-04, Vol.91 (4), p.893-901

2018

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Discovery of 4‐(isopentyloxy)‐3‐nitrobenzamide derivatives as xanthine oxidase inhibitors through a non‐anthraquinone exploration

Archiv der Pharmazie (Weinheim), 2024-10, Vol.357 (10), p.e2400137-n/a

2024

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Characterization of Oligomeric Human Half-ABC Transporter ATP-binding Cassette G2

The Journal of biological chemistry, 2004-05, Vol.279 (19), p.19781-19789

2004

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Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity

Cell death & disease, 2019-07, Vol.10 (7), p.532-16, Article 532

2019

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Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase

ACS catalysis, 2014-10, Vol.4 (10), p.3444-3453

2014

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Two decades of research in discovery of anticancer drugs targeting STAT3, how close are we?

Cholesterol esterification inhibition and gemcitabine synergistically suppress pancreatic ductal adenocarcinoma proliferation

eIF3a regulation of mTOR signaling and translational control via HuR in cellular response to DNA damage

Targeting survivin for therapeutic discovery: past, present, and future promises

Rerouting engineered metal-dependent shapes of mesoporous silica nanocontainers to biodegradable Janus-type (sphero-ellipsoid) nanoreactors for chemodynamic therapy

Identification of Novel Src Inhibitors: Pharmacophore-Based Virtual Screening, Molecular Docking and Molecular Dynamics Simulations

eIF3a: A new anticancer drug target in the eIF family

Near-Infrared-Activated Lysosome Pathway Death Induced by ROS Generated from Layered Double Hydroxide-Copper Sulfide Nanocomposites

A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction

A Small Molecule Compound Targeting STAT3 DNA-Binding Domain Inhibits Cancer Cell Proliferation, Migration, and Invasion

14-3-3σ Contributes to Radioresistance By Regulating DNA Repair and Cell Cycle via PARP1 and CHK2

Novel synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth

Dual Functional Modification of Alkaline Amino Acids Induces the Self‐Assembly of Cylinder‐Like Tobacco Mosaic Virus Coat Proteins into Gear‐Like Architectures

Proline Isomerization: From the Chemistry and Biology to Therapeutic Opportunities

Dual-responsive nanomotors for deep tumor penetration and subcellular arrangement

APC Loss Prevents Doxorubicin-Induced Cell Death by Increasing Drug Efflux and a Chemoresistant Cell Population in Breast Cancer

Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide production[S]

Dynamic vs static ABCG2 inhibitors to sensitize drug resistant cancer cells

Design, synthesis, and biological evaluation of 5‐(4‐(pyridin‐4‐yl)‐1H‐1,2,3‐triazol‐1‐yl)benzonitrile derivatives as xanthine oxidase inhibitors

Discovery and biological evaluation of some (1H-1,2,3-triazol-4-yl)methoxybenzaldehyde derivatives containing an anthraquinone moiety as potent xanthine oxidase inhibitors

Design, synthesis, and molecular docking studies of N‐(9,10‐anthraquinone‐2‐carbonyl)amino acid derivatives as xanthine oxidase inhibitors

Discovery of 4‐(isopentyloxy)‐3‐nitrobenzamide derivatives as xanthine oxidase inhibitors through a non‐anthraquinone exploration

Characterization of Oligomeric Human Half-ABC Transporter ATP-binding Cassette G2

Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity

Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase

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