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NMNAT: It’s an NAD+ synthase… It’s a chaperone… It’s a neuroprotector

Current opinion in genetics & development, 2017-06, Vol.44, p.156-162

2017

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Nmnat restores neuronal integrity by neutralizing mutant Huntingtin aggregate-induced progressive toxicity

Proceedings of the National Academy of Sciences - PNAS, 2019-09, Vol.116 (38), p.19165-19175

2019

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Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology

eLife, 2022-09, Vol.11

2022

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NMNAT suppresses Tau-induced neurodegeneration by promoting clearance of hyperphosphorylated Tau oligomers in a Drosophila model of tauopathy

Human molecular genetics, 2012-01, Vol.21 (2), p.237-250

2012

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NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis

eLife, 2021-12, Vol.10

2021

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Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress

Nature communications, 2015-11, Vol.6 (1), p.10057-10057, Article 10057

2015

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Assaying locomotor, learning, and memory deficits in Drosophila models of neurodegeneration

Journal of visualized experiments, 2011-03 (49)

2011

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Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome

Nature communications, 2017-11, Vol.8 (1), p.1257-15, Article 1257

2017

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Human Nmnat1 Promotes Autophagic Clearance of Amyloid Plaques in a Drosophila Model of Alzheimer's Disease

Frontiers in aging neuroscience, 2022-03, Vol.14, p.852972-852972

2022

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Reduction of spermine synthase enhances autophagy to suppress Tau accumulation

Cell death & disease, 2024-05, Vol.15 (5), p.333-10, Article 333

2024

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CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

Human molecular genetics, 2012-01, Vol.21 (2), p.251-267

2012

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Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome

EMBO molecular medicine, 2023-11, Vol.15 (11), p.e17833-n/a

2023

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NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

Nature, 2008-04, Vol.452 (7189), p.887-891

2008

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NMNATs, evolutionarily conserved neuronal maintenance factors

Trends in neurosciences (Regular ed.), 2013-11, Vol.36 (11), p.632-640

2013

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Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss

Proceedings of the National Academy of Sciences - PNAS, 2019-01, Vol.116 (4), p.1347-1352

2019

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Nmnat mitigates sensory dysfunction in a Drosophila model of paclitaxel-induced peripheral neuropathy

Disease models & mechanisms, 2018-06, Vol.11 (6)

2018

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The Architecture of the Active Zone in the Presynaptic Nerve Terminal

Physiology (Bethesda, Md.), 2004-10, Vol.19 (5), p.262-270

2004

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Filtration Efficiency of Air Conditioner Filters and Face Masks to Limit Exposure to Aerosolized Algal Toxins

Aerosol and Air Quality Research, 2021-08, Vol.21 (8), p.1-12+s1-11-013

2021

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Exposure to Aerosolized Algal Toxins in South Florida Increases Short- and Long-Term Health Risk in Drosophila Model of Aging

Toxins, 2020-12, Vol.12 (12), p.787

2020

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microRNA-92a regulates the expression of aphid bacteriocyte-specific secreted protein 1

BMC research notes, 2019-09, Vol.12 (1), p.638-638, Article 638

2019

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Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity

PLoS biology, 2006-12, Vol.4 (12), p.e416-e416

2006

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Sorbitol reduction via govorestat ameliorates synaptic dysfunction and neurodegeneration in sorbitol dehydrogenase deficiency

JCI insight, 2023-05, Vol.8 (10)

2023

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Phenylbutyrate modulates polyamine acetylase and ameliorates Snyder-Robinson syndrome in a Drosophila model and patient cells

JCI insight, 2022-07, Vol.7 (13)

2022

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The role of autophagy in Nmnat-mediated protection against hypoxia-induced dendrite degeneration

Molecular and cellular neuroscience, 2013-01, Vol.52, p.140-151

2013

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Dealing with misfolded proteins: examining the neuroprotective role of molecular chaperones in neurodegeneration

Molecules, 2010-10, Vol.15 (10), p.6859-6887

2010

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NMNAT: It’s an NAD+ synthase… It’s a chaperone… It’s a neuroprotector

Nmnat restores neuronal integrity by neutralizing mutant Huntingtin aggregate-induced progressive toxicity

Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology

NMNAT suppresses Tau-induced neurodegeneration by promoting clearance of hyperphosphorylated Tau oligomers in a Drosophila model of tauopathy

NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis

Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress

Assaying locomotor, learning, and memory deficits in Drosophila models of neurodegeneration

Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome

Human Nmnat1 Promotes Autophagic Clearance of Amyloid Plaques in a Drosophila Model of Alzheimer's Disease

Reduction of spermine synthase enhances autophagy to suppress Tau accumulation

CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

NMNATs, evolutionarily conserved neuronal maintenance factors

Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss

Nmnat mitigates sensory dysfunction in a Drosophila model of paclitaxel-induced peripheral neuropathy

The Architecture of the Active Zone in the Presynaptic Nerve Terminal

Filtration Efficiency of Air Conditioner Filters and Face Masks to Limit Exposure to Aerosolized Algal Toxins

Exposure to Aerosolized Algal Toxins in South Florida Increases Short- and Long-Term Health Risk in Drosophila Model of Aging

microRNA-92a regulates the expression of aphid bacteriocyte-specific secreted protein 1

Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity

Sorbitol reduction via govorestat ameliorates synaptic dysfunction and neurodegeneration in sorbitol dehydrogenase deficiency

Phenylbutyrate modulates polyamine acetylase and ameliorates Snyder-Robinson syndrome in a Drosophila model and patient cells

The role of autophagy in Nmnat-mediated protection against hypoxia-induced dendrite degeneration

Dealing with misfolded proteins: examining the neuroprotective role of molecular chaperones in neurodegeneration

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