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Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor

Cancer cell, 2021-10, Vol.39 (10), p.1404-1421.e11

2021

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Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer

Journal of medicinal chemistry, 2021-07, Vol.64 (13), p.9056-9077

2021

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Synthesis of oxetane-3-carboxaldehyde and methyl oxetane-3-carboxylate via homologation of oxetane-3-one

Tetrahedron, 2016-06, Vol.72 (26), p.3641-3646

2016

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One-Pot, Metal- and Azide-Free Synthesis of 1,2,3-Triazoles from α-Ketoacetals and Amines

Synlett, 2020-01, Vol.31 (2), p.175-178

2020

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A Formal [3 + 3] Cycloaddition Reaction. Improved Reactivity Using α,β-Unsaturated Iminium Salts and Evidence for Reversibility of 6π-Electron Electrocyclic Ring Closure of 1-Oxatrienes

Journal of organic chemistry, 2003-03, Vol.68 (5), p.1729-1735

2003

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The total synthesis of (±)-arisugacin A

Tetrahedron, 2003-01, Vol.59 (3), p.311-324

2003

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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497)

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.650-665

2018

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A Concise Stereoselective Route to the Pentacyclic Frameworks of Arisugacin A and Territrem B

Angewandte Chemie (International ed.), 2000-11, Vol.39 (21), p.3876-3879

2000

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Design and Characterization of a Pyridone-Containing EZH2 Inhibitor Phosphate Prodrug

Journal of medicinal chemistry, 2021-02, Vol.64 (3), p.1725-1732

2021

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Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195)

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.644-661

2021

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Design, synthesis, and biological evaluation of novel human 5′-deoxy-5′-methylthioadenosine phosphorylase (MTAP) substrates

Bioorganic & medicinal chemistry letters, 2005-06, Vol.15 (11), p.2829-2833

2005

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A Rare Acid-Promoted Elimination of O-Methyl Oximes: A Practical Synthesis of 3-Cyano-4-benzopyrones

Journal of organic chemistry, 1999-11, Vol.64 (23), p.8736-8740

1999

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Stereoselective trans- and cis-Dihydroxylations of 2H-Pyranyl and Dihydropyridinyl Heterocycles Synthesized from Formal [3 + 3]-Cycloaddition Reactions of α,β-Unsaturated Iminium Ions with 1,3-Dicarbonyl Equivalents

Organic letters, 2001-07, Vol.3 (14), p.2141-2144

2001

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Pyridine-3-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents

Bioorganic & medicinal chemistry letters, 2006-12, Vol.16 (23), p.6120-6123

2006

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Lewis acid mediated condensation reactions of α,β-unsaturated acids with 4-hydroxy-2-pyrones. A concise structural assignment of Fleischmann’s α,α-bispyrone and Praill’s α,γ-bispyrone

Tetrahedron letters, 2000-03, Vol.41 (12), p.1901-1905

2000

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SAH derived potent and selective EZH2 inhibitors

Bioorganic & medicinal chemistry letters, 2015-04, Vol.25 (7), p.1532-1537

2015

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ChemInform Abstract: Synthesis of Oxetane‐3‐carboxaldehyde and Methyl Oxetane‐3‐carboxylate via Homologation of Oxetane‐3‐one

ChemInform, 2016-08, Vol.47 (36), p.no-no

2016

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An unexpected retro-aldol–aldol in the AB-ring in the synthesis of (±)-arisugacin A

Tetrahedron letters, 2002-04, Vol.43 (18), p.3337-3340

2002

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Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)‑5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)‑one (PF-06821497)

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.650-665

2018

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Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents

Bioorganic & medicinal chemistry letters, 2006-12, Vol.16 (23), p.6120-6123

2006

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A Concise Stereoselective Route to the Pentacyclic Frameworks of Arisugacin A and Territrem B

Angewandte Chemie, 2000-11, Vol.112 (21), p.4034-4037

2000

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Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor

Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer

Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

Synthesis of oxetane-3-carboxaldehyde and methyl oxetane-3-carboxylate via homologation of oxetane-3-one

One-Pot, Metal- and Azide-Free Synthesis of 1,2,3-Triazoles from α-Ketoacetals and Amines

A Formal [3 + 3] Cycloaddition Reaction. Improved Reactivity Using α,β-Unsaturated Iminium Salts and Evidence for Reversibility of 6π-Electron Electrocyclic Ring Closure of 1-Oxatrienes

The total synthesis of (±)-arisugacin A

A Concise Stereoselective Route to the Pentacyclic Frameworks of Arisugacin A and Territrem B

Design and Characterization of a Pyridone-Containing EZH2 Inhibitor Phosphate Prodrug

Structure-Based Drug Design and Synthesis of PI3Kα-Selective Inhibitor (PF-06843195)

Design, synthesis, and biological evaluation of novel human 5′-deoxy-5′-methylthioadenosine phosphorylase (MTAP) substrates

A Rare Acid-Promoted Elimination of O-Methyl Oximes: A Practical Synthesis of 3-Cyano-4-benzopyrones

Stereoselective trans- and cis-Dihydroxylations of 2H-Pyranyl and Dihydropyridinyl Heterocycles Synthesized from Formal [3 + 3]-Cycloaddition Reactions of α,β-Unsaturated Iminium Ions with 1,3-Dicarbonyl Equivalents

Pyridine-3-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents

Lewis acid mediated condensation reactions of α,β-unsaturated acids with 4-hydroxy-2-pyrones. A concise structural assignment of Fleischmann’s α,α-bispyrone and Praill’s α,γ-bispyrone

SAH derived potent and selective EZH2 inhibitors

ChemInform Abstract: Synthesis of Oxetane‐3‐carboxaldehyde and Methyl Oxetane‐3‐carboxylate via Homologation of Oxetane‐3‐one

Correction to Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)‑ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

An unexpected retro-aldol–aldol in the AB-ring in the synthesis of (±)-arisugacin A

Pyridine-3-propanoic acids: Discovery of dual PPARalpha/gamma agonists as antidiabetic agents

A Concise Stereoselective Route to the Pentacyclic Frameworks of Arisugacin A and Territrem B

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