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Regulation of small GTPases by GEFs, GAPs, and GDIs

Physiological reviews, 2013-01, Vol.93 (1), p.269-309

2013

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Membranes prime the RapGEF EPAC1 to transduce cAMP signaling

Nature communications, 2023-07, Vol.14 (1), p.4157-4157, Article 4157

2023

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Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule

Scientific reports, 2017-10, Vol.7 (1), p.14409-13, Article 14409

2017

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Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes

Structure (London), 2019-12, Vol.27 (12), p.1782-1797.e7

2019

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Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation

Nature communications, 2015-02, Vol.6 (1), p.6218, Article 6218

2015

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EFA6 controls Arf1 and Arf6 activation through a negative feedback loop

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (34), p.12378-12383

2014

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PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling

Nature chemical biology, 2019-04, Vol.15 (4), p.358-366

2019

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Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2

PLoS biology, 2013-09, Vol.11 (9), p.e1001652-e1001652

2013

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Publisher Correction: PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling

Nature chemical biology, 2019-05, Vol.15 (5), p.549-549

2019

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A novel membrane sensor controls the localization and ArfGEF activity of bacterial RalF

PLoS pathogens, 2013-11, Vol.9 (11), p.e1003747-e1003747

2013

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Protein Profiling with Epstein-Barr Nuclear Antigen-1 Reveals an Interaction with the Herpesvirus-associated Ubiquitin-specific Protease HAUSP/USP7

The Journal of biological chemistry, 2003-08, Vol.278 (32), p.29987-29994

2003

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Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes

Proceedings of the National Academy of Sciences - PNAS, 2007-06, Vol.104 (25), p.10370-10375

2007

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Dual Specificity of the Interfacial Inhibitor Brefeldin A for Arf Proteins and Sec7 Domains

The Journal of biological chemistry, 2006-04, Vol.281 (17), p.11805-11814

2006

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Chronicles of the GTPase switch

Nature chemical biology, 2011-07, Vol.7 (8), p.493-495

2011

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Molecular principles of bidirectional signalling between membranes and small GTPases

FEBS letters, 2023-03, Vol.597 (6), p.778-793

2023

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Protein-membrane interactions in small GTPase signalling and pharmacology: perspectives from Arf GTPases studies

Biochemical Society transactions, 2020-12, Vol.48 (6), p.2721-2728

2020

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Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function

Virology (New York, N.Y.), 2009-05, Vol.388 (1), p.103-111

2009

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RPAP1, a Novel Human RNA Polymerase II-Associated Protein Affinity Purified with Recombinant Wild-Type and Mutated Polymerase Subunits

Molecular and Cellular Biology, 2004-08, Vol.24 (16), p.7043-7058

2004

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Allosteric regulation of Arf GTPases and their GEFs at the membrane interface

Small GTPases, 2016-10, Vol.7 (4), p.283-296

2016

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Pressure study reveals conformational landscapes and structural transitions of small GTPase

Biophysical journal, 2022-02, Vol.121 (3), p.181a-181a

2022

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Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering

Biochemical journal, 2017-04, Vol.474 (7), p.1259-1272

2017

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Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

Science (American Association for the Advancement of Science), 2014-04, Vol.344 (6180), p.208-211

2014

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A Simplifed Functional Version of the Escherichia coli Sulfite Reductase

The Journal of biological chemistry, 2000-12, Vol.275 (48), p.37651-37656

2000

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Family-wide Analysis of the Inhibition of Arf Guanine Nucleotide Exchange Factors with Small Molecules: Evidence of Unique Inhibitory Profiles

Biochemistry (Easton), 2017-09, Vol.56 (38), p.5125-5133

2017

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Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes

Structure (London), 2019-12, Vol.27 (12)

2019

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Regulation of small GTPases by GEFs, GAPs, and GDIs

Membranes prime the RapGEF EPAC1 to transduce cAMP signaling

Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule

Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes

Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation

EFA6 controls Arf1 and Arf6 activation through a negative feedback loop

PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling

Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2

Publisher Correction: PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling

A novel membrane sensor controls the localization and ArfGEF activity of bacterial RalF

Protein Profiling with Epstein-Barr Nuclear Antigen-1 Reveals an Interaction with the Herpesvirus-associated Ubiquitin-specific Protease HAUSP/USP7

Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes

Dual Specificity of the Interfacial Inhibitor Brefeldin A for Arf Proteins and Sec7 Domains

Chronicles of the GTPase switch

Molecular principles of bidirectional signalling between membranes and small GTPases

Protein-membrane interactions in small GTPase signalling and pharmacology: perspectives from Arf GTPases studies

Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function

RPAP1, a Novel Human RNA Polymerase II-Associated Protein Affinity Purified with Recombinant Wild-Type and Mutated Polymerase Subunits

Allosteric regulation of Arf GTPases and their GEFs at the membrane interface

Pressure study reveals conformational landscapes and structural transitions of small GTPase

Characterization of the activation of small GTPases by their GEFs on membranes using artificial membrane tethering

Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

A Simplifed Functional Version of the Escherichia coli Sulfite Reductase

Family-wide Analysis of the Inhibition of Arf Guanine Nucleotide Exchange Factors with Small Molecules: Evidence of Unique Inhibitory Profiles

Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes

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