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PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating

Frontiers in physiology, 2014-05, Vol.5, p.195-195

2014

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Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening

Proceedings of the National Academy of Sciences - PNAS, 2013-08, Vol.110 (32), p.13180-13185

2013

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Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation

Nature communications, 2020-02, Vol.11 (1), p.676-676, Article 676

2020

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PIP₂-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6

Scientific reports, 2015-01, Vol.5 (1), p.7474, Article 7474

2015

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KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity

Proceedings of the National Academy of Sciences - PNAS, 2011-05, Vol.108 (22), p.9095-9100

2011

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Diagnosis of red meat allergy with antigen-specific IgE tests in serum

Journal of allergy and clinical immunology, 2017-08, Vol.140 (2), p.608-610.e5

2017

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Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel

eLife, 2014-12, Vol.3, p.e03606-e03606

2014

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Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes

eLife, 2022-08, Vol.11

2022

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Direct Measurement of Cardiac Na+ Channel Conformations Reveals Molecular Pathologies of Inherited Mutations

Circulation. Arrhythmia and electrophysiology, 2015-10, Vol.8 (5), p.1228-1239

2015

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Use of the Current Standard of Practice Serum Free Light Chains (sFLC) Reference Interval Puts Black Patients at 5 Times Higher Odds for Light Chain Monoclonal Gammopathy of Undetermined Significance (LC-MGUS)

Clinical chemistry (Baltimore, Md.), 2023-09, Vol.69 (9), p.1084-1086

2023

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Clinical implications of inaccurate potassium determination in hemolyzed pediatric blood specimens

Clinica chimica acta, 2024-04, Vol.557, p.117862-117862, Article 117862

2024

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A phytobacterial TIR domain effector manipulates NAD+ to promote virulence

The New phytologist, 2022-01, Vol.233 (2), p.890-904

2022

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Generative Artificial Intelligence: More of the Same or Off the Control Chart?

Clinical chemistry (Baltimore, Md.), 2023-10, Vol.69 (10), p.1101-1106

2023

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Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling

Science (American Association for the Advancement of Science), 2022-09, Vol.377 (6614), p.eadc8969

2022

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Optimizing Equity: Working towards Fair Machine Learning Algorithms in Laboratory Medicine

The journal of applied laboratory medicine, 2023-01, Vol.8 (1), p.113-128

2023

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Clinical Utility of LC-MS/MS for Blood Myo-Inositol in Patients with Acute Kidney Injury and Chronic Kidney Disease

Clinical chemistry (Baltimore, Md.), 2024-08

2024

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Automating the Detection of IV Fluid Contamination Using Unsupervised Machine Learning

Clinical chemistry (Baltimore, Md.), 2024-02, Vol.70 (2), p.444-452

2024

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Generalizability of a Machine Learning Model for Improving Utilization of Parathyroid Hormone-Related Peptide Testing across Multiple Clinical Centers

Clinical chemistry (Baltimore, Md.), 2023-11, Vol.69 (11), p.1260-1269

2023

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Working with the Electronic Health Record and Laboratory Information System to Maximize Ordering and Reporting of Molecular Microbiology Results

Clinics in laboratory medicine, 2024-03, Vol.44 (1), p.95-107

2024

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A Single Reference Interval for Interpreting Serum Free Light Chains across Patients with Varying Renal Function

Clinical chemistry (Baltimore, Md.), 2023-06, Vol.69 (6), p.595-605

2023

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By Pathologists for Pathologists: Solving Common Informatics Problems in Laboratory Medicine with Open-Source Software Solutions

The journal of applied laboratory medicine, 2023-01, Vol.8 (1), p.11-13

2023

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Data Analytics in Clinical Laboratories: Advancing Diagnostic Medicine in the Digital Age

Clinical chemistry (Baltimore, Md.), 2023-12, Vol.69 (12), p.1333-1341

2023

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Ion Channel Associated Diseases: Overview of Molecular Mechanisms

Chemical reviews, 2012-12, Vol.112 (12), p.6319-6333

2012

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Using information theory to optimize a diagnostic threshold to match physician-ordering practice

Journal of biomedical informatics, 2021-05, Vol.117, p.103756-103756, Article 103756

2021

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State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation

The Journal of general physiology, 2010-06, Vol.135 (6), p.595-606

2010

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PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating

Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening

Two-stage electro–mechanical coupling of a KV channel in voltage-dependent activation

PIP₂-dependent coupling is prominent in Kv7.1 due to weakened interactions between S4-S5 and S6

KCNE1 enhances phosphatidylinositol 4,5-bisphosphate (PIP2) sensitivity of IKs to modulate channel activity

Diagnosis of red meat allergy with antigen-specific IgE tests in serum

Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel

Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes

Direct Measurement of Cardiac Na+ Channel Conformations Reveals Molecular Pathologies of Inherited Mutations

Use of the Current Standard of Practice Serum Free Light Chains (sFLC) Reference Interval Puts Black Patients at 5 Times Higher Odds for Light Chain Monoclonal Gammopathy of Undetermined Significance (LC-MGUS)

Clinical implications of inaccurate potassium determination in hemolyzed pediatric blood specimens

A phytobacterial TIR domain effector manipulates NAD+ to promote virulence

Generative Artificial Intelligence: More of the Same or Off the Control Chart?

Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling

Optimizing Equity: Working towards Fair Machine Learning Algorithms in Laboratory Medicine

Clinical Utility of LC-MS/MS for Blood Myo-Inositol in Patients with Acute Kidney Injury and Chronic Kidney Disease

Automating the Detection of IV Fluid Contamination Using Unsupervised Machine Learning

Generalizability of a Machine Learning Model for Improving Utilization of Parathyroid Hormone-Related Peptide Testing across Multiple Clinical Centers

Working with the Electronic Health Record and Laboratory Information System to Maximize Ordering and Reporting of Molecular Microbiology Results

A Single Reference Interval for Interpreting Serum Free Light Chains across Patients with Varying Renal Function

By Pathologists for Pathologists: Solving Common Informatics Problems in Laboratory Medicine with Open-Source Software Solutions

Data Analytics in Clinical Laboratories: Advancing Diagnostic Medicine in the Digital Age

Ion Channel Associated Diseases: Overview of Molecular Mechanisms

Using information theory to optimize a diagnostic threshold to match physician-ordering practice

State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation

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