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Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility

Journal of medicinal chemistry, 2016-08, Vol.59 (15), p.7011-7028

Zaveri, Nurulain T

2016

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Green tea and its polyphenolic catechins: Medicinal uses in cancer and noncancer applications

Life sciences (1973), 2006-03, Vol.78 (18), p.2073-2080

Zaveri, Nurulain T.

2006

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The nociceptin/orphanin FQ receptor (NOP) as a target for drug abuse medications

Current topics in medicinal chemistry, 2011-05, Vol.11 (9), p.1151

Zaveri, Nurulain T

2011

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A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates

Science translational medicine, 2018-08, Vol.10 (456)

2018

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Attenuated G protein signaling and minimal receptor phosphorylation as a biochemical signature of low side-effect opioid analgesics

Scientific reports, 2022-05, Vol.12 (1), p.7154-7154, Article 7154

2022

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Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists

Science signaling, 2019-03, Vol.12 (574)

2019

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TRPM8 ion channel ligands for new therapeutic applications and as probes to study menthol pharmacology

Life sciences (1973), 2013-03, Vol.92 (8-9), p.425-437

2013

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NOP receptor pharmacological profile - A dynamic mass redistribution study

PloS one, 2018-08, Vol.13 (8), p.e0203021-e0203021

2018

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Homology modeling and molecular dynamics simulations of the active state of the nociceptin receptor reveal new insights intoagonist binding and activation

Proteins, structure, function, and bioinformatics, 2012-08, Vol.80 (8), p.1948-1961

2012

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Structure-Based Virtual Screening of the Nociceptin Receptor: Hybrid Docking and Shape-Based Approaches for Improved Hit Identification

Journal of chemical information and modeling, 2014-10, Vol.54 (10), p.2732-2743

2014

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Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice

Haematologica (Roma), 2015-12, Vol.100 (12), p.1517

2015

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Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists

Frontiers in neuroscience, 2021-03, Vol.15, p.657153-657153

2021

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Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease

Neurobiology of disease, 2016-05, Vol.89, p.55-64

2016

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The Nociceptin Receptor (NOP) Agonist AT-312 Blocks Acquisition of Morphine- and Cocaine-Induced Conditioned Place Preference in Mice

Frontiers in psychiatry, 2018-11, Vol.9, p.638-638

2018

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The first universal opioid ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): characterization of the in vitro profile and in vivo behavioral effects in mouse models of acute pain and cocaine-induced reward

The Journal of pharmacology and experimental therapeutics, 2011-03, Vol.336 (3), p.952

2011

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Small molecule NOP agonists reverse locomotor sensitization induced by cocaine in male C57BL/6 mice

Progress in neuro-psychopharmacology & biological psychiatry, 2024-04, Vol.131, p.110941-110941, Article 110941

2024

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Designing bifunctional NOP receptor–mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I

Bioorganic & medicinal chemistry letters, 2013-06, Vol.23 (11), p.3308-3313

2013

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Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems

Pharmacological reviews, 2016-04, Vol.68 (2), p.419-457

2016

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Designing bifunctional NOP receptor–mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II

Bioorganic & medicinal chemistry, 2014-04, Vol.22 (8), p.2508-2516

2014

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Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor

Neuron (Cambridge, Mass.), 2019-11, Vol.104 (3), p.501-511.e6

2019

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Discovery and structure-activity relationships (SAR) of a novel class of 2-substituted N-piperidinyl indole-based nociceptin opioid receptor ligands

Bioorganic & medicinal chemistry, 2023-09, Vol.92, p.117421-117421, Article 117421

2023

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Managing Parkinson's disease: moving ON with NOP

British journal of pharmacology, 2020-01, Vol.177 (1), p.28-47

2020

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Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility: Miniperspective

Journal of medicinal chemistry, 2016-08, Vol.59 (15), p.7011-7028

Zaveri, Nurulain T

2016

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Acute single non-sedative doses of NOP receptor agonists affect acquisition of object location memory but repeated high doses do not induce long-lasting deficits

Neurobiology of learning and memory, 2023-11, Vol.205, p.107841-107841, Article 107841

2023

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Potent and selective NOP receptor activation reduces cocaine self‐administration in rats by lowering hedonic set point

Addiction biology, 2020-11, Vol.25 (6), p.e12844-n/a

2020

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Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility

Green tea and its polyphenolic catechins: Medicinal uses in cancer and noncancer applications

The nociceptin/orphanin FQ receptor (NOP) as a target for drug abuse medications

A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates

Attenuated G protein signaling and minimal receptor phosphorylation as a biochemical signature of low side-effect opioid analgesics

Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists

TRPM8 ion channel ligands for new therapeutic applications and as probes to study menthol pharmacology

NOP receptor pharmacological profile - A dynamic mass redistribution study

Homology modeling and molecular dynamics simulations of the active state of the nociceptin receptor reveal new insights intoagonist binding and activation

Structure-Based Virtual Screening of the Nociceptin Receptor: Hybrid Docking and Shape-Based Approaches for Improved Hit Identification

Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice

Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists

Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease

The Nociceptin Receptor (NOP) Agonist AT-312 Blocks Acquisition of Morphine- and Cocaine-Induced Conditioned Place Preference in Mice

The first universal opioid ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): characterization of the in vitro profile and in vivo behavioral effects in mouse models of acute pain and cocaine-induced reward

Small molecule NOP agonists reverse locomotor sensitization induced by cocaine in male C57BL/6 mice

Designing bifunctional NOP receptor–mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I

Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems

Designing bifunctional NOP receptor–mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II

Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor

Discovery and structure-activity relationships (SAR) of a novel class of 2-substituted N-piperidinyl indole-based nociceptin opioid receptor ligands

Managing Parkinson's disease: moving ON with NOP

Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility: Miniperspective

Acute single non-sedative doses of NOP receptor agonists affect acquisition of object location memory but repeated high doses do not induce long-lasting deficits

Potent and selective NOP receptor activation reduces cocaine self‐administration in rats by lowering hedonic set point

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