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Glucolipotoxicity of the pancreatic beta cell

Biochimica et biophysica acta, 2010-03, Vol.1801 (3), p.289-298

2010

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Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats

Diabetologia, 2017-05, Vol.60 (5), p.879-888

2017

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Skeletal muscle insulin resistance is induced by 4-hydroxy-2-hexenal, a by-product of n-3 fatty acid peroxidation

Diabetologia, 2018-03, Vol.61 (3), p.688-699

2018

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The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes

PloS one, 2014-02, Vol.9 (2), p.e87941-e87941

2014

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The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets

Molecular metabolism (Germany), 2016-10, Vol.5 (10), p.988-996

2016

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An Obesogenic Dietary Mouse Model of Nonalcoholic Steatohepatitis

Methods in molecular biology (Clifton, N.J.), 2020, Vol.2164, p.121

2020

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Chronotherapy with a glucokinase activator profoundly improves metabolism in obese Zucker rats

Science translational medicine, 2022-10, Vol.14 (668), p.eabh1316

2022

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The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice

Diabetes (New York, N.Y.), 2015-12, Vol.64 (12), p.4112-4122

2015

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Human Uremic Plasma and not Urea Induces Exuberant Secretion of Leptin in 3T3-L1 Adipocytes

Journal of renal nutrition, 2011, Vol.21 (1), p.72-75

2011

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Ozone exposure triggers insulin resistance through muscle c-Jun N-terminal kinase activation

Diabetes (New York, N.Y.), 2015-03, Vol.64 (3), p.1011-1024

2015

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193-OR: Chronotherapy with the Glucokinase Activator AZD1656 Greatly Affects Its Ability to Improve Metabolism in Obese Zucker Rats

Diabetes (New York, N.Y.), 2022-06, Vol.71 (Supplement_1)

2022

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Epidermal Growth Factor Receptor Signaling Promotes Pancreatic β-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1

Diabetes (New York, N.Y.), 2014-03, Vol.63 (3), p.982-993

2014

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Age prediction from human blood plasma using proteomic and small RNA data: a comparative analysis

Aging (Albany, NY.), 2023-06, Vol.15 (12), p.5240-5265

2023

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Discovery by Virtual Screening of an Inhibitor of CDK5-Mediated PPARγ Phosphorylation

ACS medicinal chemistry letters, 2022-04, Vol.13 (4), p.681-686

2022

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β-Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced β-Cell Mass

Diabetes (New York, N.Y.), 2010-09, Vol.59 (9), p.2178-2187

2010

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The [Delta]F508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional [Beta]-Cell Mass in Mice

Diabetes (New York, N.Y.), 2015-12, Vol.64 (12), p.4112

2015

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Epidermal Growth Factor Receptor Signaling Promotes Pancreatic [Beta]-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1

Diabetes (New York, N.Y.), 2014-03, Vol.63 (3), p.982

2014

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Per-Arnt-Sim Kinase Regulates Pancreatic Duodenal Homeobox-1 Protein Stability via Phosphorylation of Glycogen Synthase Kinase 3β in Pancreatic β-Cells

The Journal of biological chemistry, 2013-08, Vol.288 (34), p.24825-24833

2013

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Npas4 Is a Novel Activity-Regulated Cytoprotective Factor in Pancreatic β-Cells

Diabetes (New York, N.Y.), 2013-08, Vol.62 (8), p.2808-2820

2013

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Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes

Science advances, 2022-11, Vol.8 (46), p.eadd5430-eadd5430

2022

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Pancreatic and duodenal homeobox-1 nuclear localization is regulated by glucose in dispersed rat islets but not in insulin-secreting cell lines

Islets, 2014-01, Vol.6 (4), p.e982376-e982376

2014

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A Model of Chronic Nutrient Infusion in the Rat

Journal of visualized experiments, 2013-08 (78)

2013

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The Islet Estrogen Receptor-[alpha] Is Induced by Hyperglycemia and Protects Against Oxidative Stress-Induced Insulin-Deficient Diabetes

PloS one, 2014-02, Vol.9 (2), p.e87941

2014

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Npas4 is a novel activity--regulated cytoprotective factor in pancreatic [beta]-cells

Diabetes (New York, N.Y.), 2013-08, Vol.62 (8), p.2808

2013

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Lou/C Obesity-resistant Rat Exhibits Hyperactivity, Hypermetabolism, Alterations in White Adipose Tissue Cellularity, and Lipid Tissue Profiles

Endocrinology (Philadelphia), 2008-02, Vol.149 (2), p.615-625

2008

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Glucolipotoxicity of the pancreatic beta cell

Glucose and fatty acids synergistically and reversibly promote beta cell proliferation in rats

Skeletal muscle insulin resistance is induced by 4-hydroxy-2-hexenal, a by-product of n-3 fatty acid peroxidation

The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes

The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets

An Obesogenic Dietary Mouse Model of Nonalcoholic Steatohepatitis

Chronotherapy with a glucokinase activator profoundly improves metabolism in obese Zucker rats

The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice

Human Uremic Plasma and not Urea Induces Exuberant Secretion of Leptin in 3T3-L1 Adipocytes

Ozone exposure triggers insulin resistance through muscle c-Jun N-terminal kinase activation

193-OR: Chronotherapy with the Glucokinase Activator AZD1656 Greatly Affects Its Ability to Improve Metabolism in Obese Zucker Rats

Epidermal Growth Factor Receptor Signaling Promotes Pancreatic β-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1

Age prediction from human blood plasma using proteomic and small RNA data: a comparative analysis

Discovery by Virtual Screening of an Inhibitor of CDK5-Mediated PPARγ Phosphorylation

β-Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced β-Cell Mass

The [Delta]F508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional [Beta]-Cell Mass in Mice

Epidermal Growth Factor Receptor Signaling Promotes Pancreatic [Beta]-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1

Per-Arnt-Sim Kinase Regulates Pancreatic Duodenal Homeobox-1 Protein Stability via Phosphorylation of Glycogen Synthase Kinase 3β in Pancreatic β-Cells

Npas4 Is a Novel Activity-Regulated Cytoprotective Factor in Pancreatic β-Cells

Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes

Pancreatic and duodenal homeobox-1 nuclear localization is regulated by glucose in dispersed rat islets but not in insulin-secreting cell lines

A Model of Chronic Nutrient Infusion in the Rat

The Islet Estrogen Receptor-[alpha] Is Induced by Hyperglycemia and Protects Against Oxidative Stress-Induced Insulin-Deficient Diabetes

Npas4 is a novel activity--regulated cytoprotective factor in pancreatic [beta]-cells

Lou/C Obesity-resistant Rat Exhibits Hyperactivity, Hypermetabolism, Alterations in White Adipose Tissue Cellularity, and Lipid Tissue Profiles

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