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Modified mRNA as a Therapeutic Tool for the Heart

Cardiovascular drugs and therapy, 2020-12, Vol.34 (6), p.871-880

2020

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Lipid Nanoparticles for Organ-Specific mRNA Therapeutic Delivery

Pharmaceutics, 2021-10, Vol.13 (10), p.1675

2021

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Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages

Nature communications, 2020-08, Vol.11 (1), p.4311-4311, Article 4311

2020

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Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration

Circulation (New York, N.Y.), 2020-04, Vol.141 (15), p.1249-1265

2020

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Altering Sphingolipid Metabolism Attenuates Cell Death and Inflammatory Response After Myocardial Infarction

Circulation (New York, N.Y.), 2020-03, Vol.141 (11), p.916-930

2020

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Synthetic MicroRNAs Stimulate Cardiac Repair

Circulation research, 2017-04, Vol.120 (8), p.1222-1223

2017

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Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

Nature biotechnology, 2013-10, Vol.31 (10), p.898-907

2013

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How to make a cardiomyocyte

Development (Cambridge), 2014-12, Vol.141 (23), p.4418-4431

2014

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Direct Imaging of Immune Rejection and Memory Induction by Allogeneic Mesenchymal Stromal Cells

Stem cells (Dayton, Ohio), 2009-11, Vol.27 (11), p.2865-2874

2009

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Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration

Nature communications, 2022-12, Vol.13 (1), p.7704-18, Article 7704

2022

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Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury

Circulation (New York, N.Y.), 2017-01, Vol.135 (1), p.59-72

2017

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Ablation of a Single N-Glycosylation Site in Human FSTL 1 Induces Cardiomyocyte Proliferation and Cardiac Regeneration

Molecular therapy. Nucleic acids, 2018-12, Vol.13, p.133-143

2018

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Modified mRNA-Mediated CCN5 Gene Transfer Ameliorates Cardiac Dysfunction and Fibrosis without Adverse Structural Remodeling

International journal of molecular sciences, 2024-06, Vol.25 (11), p.6262

2024

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Direct reprogramming induces vascular regeneration post muscle ischemic injury

Molecular therapy, 2021-10, Vol.29 (10), p.3042-3058

2021

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Modified mRNA Formulation and Stability for Cardiac and Skeletal Muscle Delivery

Pharmaceutics, 2023-08, Vol.15 (9), p.2176

2023

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mRNA-Based Protein Replacement Therapy for the Heart

Molecular therapy, 2019-04, Vol.27 (4), p.785-793

2019

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Therapeutic Delivery of Pip4k2c‐Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart

Advanced science, 2021-05, Vol.8 (10), p.2004661-n/a

2021

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Isolation and characterization of nontubular Sca-1+Lin- multipotent stem/progenitor cells from adult mouse kidney

Journal of the American Society of Nephrology, 2006-12, Vol.17 (12), p.3300-3314

2006

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Optimization of 5′ Untranslated Region of Modified mRNA for Use in Cardiac or Hepatic Ischemic Injury

Molecular therapy. Methods & clinical development, 2020-06, Vol.17, p.622-633

2020

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Cardiovascular regenerative therapeutics via synthetic paracrine factor modified mRNA

Stem cell research, 2014-11, Vol.13 (3), p.693-704

2014

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MODIFIED RNA ENCODING FOR ANTI-MULLERIAN HORMONE CONFERS OVARIAN PROTECTION FROM CYCLOPHOSPHAMIDE IN BOTH MOUSE AND HUMAN XENOGRAFT MODELS

Fertility and sterility, 2020-09, Vol.114 (3), p.e227-e227

2020

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Reconstruction of cell lineage trees in mice

PloS one, 2008-04, Vol.3 (4), p.e1939-e1939

2008

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Optimization of Synthesis of Modified mRNA

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2573, p.77

2022

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Synthesis of Modified mRNA for Myocardial Delivery

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1521, p.127

2017

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ADMINISTRATION OF MODIFIED RNA ENCODING ANTI-MULLERIAN HORMONE (MODRNA-AMH) BEFORE CYCLOPHOSPHAMIDE BRIDGES PROTEIN LOSS UNTIL RESUMPTION OF SECRETION BY A CRITICAL MASS OF GROWING FOLLICLES

Fertility and sterility, 2023-10, Vol.120 (4), p.e119-e119

2023

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Modified mRNA as a Therapeutic Tool for the Heart

Lipid Nanoparticles for Organ-Specific mRNA Therapeutic Delivery

Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages

Pkm2 Regulates Cardiomyocyte Cell Cycle and Promotes Cardiac Regeneration

Altering Sphingolipid Metabolism Attenuates Cell Death and Inflammatory Response After Myocardial Infarction

Synthetic MicroRNAs Stimulate Cardiac Repair

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

How to make a cardiomyocyte

Direct Imaging of Immune Rejection and Memory Induction by Allogeneic Mesenchymal Stromal Cells

Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration

Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury

Ablation of a Single N-Glycosylation Site in Human FSTL 1 Induces Cardiomyocyte Proliferation and Cardiac Regeneration

Modified mRNA-Mediated CCN5 Gene Transfer Ameliorates Cardiac Dysfunction and Fibrosis without Adverse Structural Remodeling

Direct reprogramming induces vascular regeneration post muscle ischemic injury

Modified mRNA Formulation and Stability for Cardiac and Skeletal Muscle Delivery

mRNA-Based Protein Replacement Therapy for the Heart

Therapeutic Delivery of Pip4k2c‐Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart

Isolation and characterization of nontubular Sca-1+Lin- multipotent stem/progenitor cells from adult mouse kidney

Optimization of 5′ Untranslated Region of Modified mRNA for Use in Cardiac or Hepatic Ischemic Injury

Cardiovascular regenerative therapeutics via synthetic paracrine factor modified mRNA

MODIFIED RNA ENCODING FOR ANTI-MULLERIAN HORMONE CONFERS OVARIAN PROTECTION FROM CYCLOPHOSPHAMIDE IN BOTH MOUSE AND HUMAN XENOGRAFT MODELS

Reconstruction of cell lineage trees in mice

Optimization of Synthesis of Modified mRNA

Synthesis of Modified mRNA for Myocardial Delivery

ADMINISTRATION OF MODIFIED RNA ENCODING ANTI-MULLERIAN HORMONE (MODRNA-AMH) BEFORE CYCLOPHOSPHAMIDE BRIDGES PROTEIN LOSS UNTIL RESUMPTION OF SECRETION BY A CRITICAL MASS OF GROWING FOLLICLES

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