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A phase I/II study on intracerebroventricular tralesinidase alfa in patients with Sanfilippo syndrome type B

The Journal of clinical investigation, 2023-01, Vol.133 (2), p.1-13

2023

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Safety, pharmacokinetics and CNS distribution of tralesinidase alfa administered via intracerebroventricular infusion to juvenile cynomolgus monkeys

Toxicology reports, 2023-01, Vol.10, p.357-366

2023

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Macrophage-specific chemokines induced via innate immunity by amino acid copolymers and their role in EAE

PloS one, 2011-12, Vol.6 (12), p.e26274-e26274

2011

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Community consensus for Heparan sulfate as a biomarker to support accelerated approval in Neuronopathic Mucopolysaccharidoses

Molecular genetics and metabolism, 2024-08, Vol.142 (4), p.108535, Article 108535

2024

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Characterization of binding, functional activity, and contractile responses of the selective 5‐HT1F receptor agonist lasmiditan

British journal of pharmacology, 2019-12, Vol.176 (24), p.4681-4695

2019

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Longitudinal natural history of pediatric subjects affected with mucopolysaccharidosis IIIB

The Journal of pediatrics, 2022-10, Vol.249, p.50-58.e2

2022

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HLA-DQ-associated predisposition to and dominant HLA-DR-associated protection against rheumatoid arthritis

Human immunology, 1999-02, Vol.60 (2), p.152-158

1999

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Tralesinidase alfa (AX 250) enzyme replacement therapy for Sanfilippo syndrome type B

Molecular genetics and metabolism, 2021-02, Vol.132 (2), p.S75-S75

2021

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Natural history of Sanfilippo syndrome type B in young patients: Ongoing results from two large, prospective studies

Molecular genetics and metabolism, 2021-02, Vol.132 (2), p.S44-S44

2021

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Tralesinidase Alfa Enzyme Replacement Therapy Prevents Disease Manifestations in a Canine Model of Mucopolysaccharidosis Type IIIB

The Journal of pharmacology and experimental therapeutics, 2022-09, Vol.382 (3), p.277-286

2022

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An HLA-DRB1-Derived Peptide Associated with Protection Against Rheumatoid Arthritis Is Naturally Processed by Human APCs

The Journal of immunology (1950), 2001-04, Vol.166 (8), p.4987-4993

2001

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The telomeric part of the HLA region predisposes to rheumatoid arthritis independently of the class II loci

Human immunology, 2001, Vol.62 (1), p.75-84

2001

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In Vitro Characterization of Agonist Binding and Functional Activity at a Panel of Serotonin Receptor Subtypes for Lasmiditan, Triptans and Other 5-HT Receptor Ligands and Activity Relationships for Contraction of Human Isolated Coronary Artery (S32.003)

Neurology, 2018, Vol.90 (15_supplement)

2018

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Characterization of binding, functional activity, and contractile responses of the selective 5-HT 1F receptor agonist lasmiditan

British journal of pharmacology, 2019-12, Vol.176 (24), p.4681-4695

2019

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Targeting IL-15 Receptor-Bearing Cells with an Antagonist Mutant IL-15/Fc Protein Prevents Disease Development and Progression in Murine Collagen-Induced Arthritis

The Journal of immunology (1950), 2004-11, Vol.173 (9), p.5818-5826

2004

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Protection against severe disease is conferred by DERAA-bearing HLA-DRB1 alleles among HLA-DQ3 and HLA-DQ5 positive rheumatoid arthritis patients

Human immunology, 2001-05, Vol.62 (5), p.523-529

2001

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Human leukocyte antigen-DQ and DR polymorphisms predict rheumatoid arthritis outcome better than DR alone

Human immunology, 2001-11, Vol.62 (11), p.1217-1225

2001

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Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis

Arthritis and rheumatism, 2004-07, Vol.50 (7), p.2113-2121

2004

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CD25+ cell depletion hastens the onset of severe disease in collagen‐induced arthritis

Arthritis and rheumatism, 2003-05, Vol.48 (5), p.1452-1460

2003

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Safety, Pharmacokinetic, and Pharmacodynamic Evaluations of PI-2301, a Potent Immunomodulator, in a First-in-Human, Single-Ascending-Dose Study in Healthy Volunteers

Journal of clinical pharmacology, 2011-05, Vol.51 (5), p.649-660

2011

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Genomic organization and tissue expression of the mouse proteasome gene Lmp-7

Immunogenetics (New York), 1993-09, Vol.38 (6), p.400-407

1993

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Immune Response of HLA-DQ8 Transgenic Mice to Peptides from the Third Hypervariable Region of HLA-DRB1 Correlates with Predisposition to Rheumatoid Arthritis

Proceedings of the National Academy of Sciences - PNAS, 1996-03, Vol.93 (5), p.1814-1819

1996

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Sa.98. Preclinical and Clinical Development of a Second Generation Peptide Copolymer for the Treatment of Multiple Sclerosis

Clinical immunology (Orlando, Fla.), 2008, Vol.127, p.S112-S113

2008

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Identification of HLA Class II-Restricted Determinants of Mycobacterium tuberculosis-Derived Proteins by Using HLA-Transgenic, Class II-Deficient Mice

Proceedings of the National Academy of Sciences - PNAS, 1998-09, Vol.95 (18), p.10797-10802

1998

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Critical residues on HLA-DRB10402 HV3 peptide for HLA-DQ8-restricted immunogenicity: implications for rheumatoid arthritis predisposition

The Journal of immunology (1950), 1997-04, Vol.158 (7), p.3545-3551

1997

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A phase I/II study on intracerebroventricular tralesinidase alfa in patients with Sanfilippo syndrome type B

Safety, pharmacokinetics and CNS distribution of tralesinidase alfa administered via intracerebroventricular infusion to juvenile cynomolgus monkeys

Macrophage-specific chemokines induced via innate immunity by amino acid copolymers and their role in EAE

Community consensus for Heparan sulfate as a biomarker to support accelerated approval in Neuronopathic Mucopolysaccharidoses

Characterization of binding, functional activity, and contractile responses of the selective 5‐HT1F receptor agonist lasmiditan

Longitudinal natural history of pediatric subjects affected with mucopolysaccharidosis IIIB

HLA-DQ-associated predisposition to and dominant HLA-DR-associated protection against rheumatoid arthritis

Tralesinidase alfa (AX 250) enzyme replacement therapy for Sanfilippo syndrome type B

Natural history of Sanfilippo syndrome type B in young patients: Ongoing results from two large, prospective studies

Tralesinidase Alfa Enzyme Replacement Therapy Prevents Disease Manifestations in a Canine Model of Mucopolysaccharidosis Type IIIB

An HLA-DRB1-Derived Peptide Associated with Protection Against Rheumatoid Arthritis Is Naturally Processed by Human APCs

The telomeric part of the HLA region predisposes to rheumatoid arthritis independently of the class II loci

In Vitro Characterization of Agonist Binding and Functional Activity at a Panel of Serotonin Receptor Subtypes for Lasmiditan, Triptans and Other 5-HT Receptor Ligands and Activity Relationships for Contraction of Human Isolated Coronary Artery (S32.003)

Characterization of binding, functional activity, and contractile responses of the selective 5-HT 1F receptor agonist lasmiditan

Targeting IL-15 Receptor-Bearing Cells with an Antagonist Mutant IL-15/Fc Protein Prevents Disease Development and Progression in Murine Collagen-Induced Arthritis

Protection against severe disease is conferred by DERAA-bearing HLA-DRB1 alleles among HLA-DQ3 and HLA-DQ5 positive rheumatoid arthritis patients

Human leukocyte antigen-DQ and DR polymorphisms predict rheumatoid arthritis outcome better than DR alone

Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis

CD25+ cell depletion hastens the onset of severe disease in collagen‐induced arthritis

Safety, Pharmacokinetic, and Pharmacodynamic Evaluations of PI-2301, a Potent Immunomodulator, in a First-in-Human, Single-Ascending-Dose Study in Healthy Volunteers

Genomic organization and tissue expression of the mouse proteasome gene Lmp-7

Immune Response of HLA-DQ8 Transgenic Mice to Peptides from the Third Hypervariable Region of HLA-DRB1 Correlates with Predisposition to Rheumatoid Arthritis

Sa.98. Preclinical and Clinical Development of a Second Generation Peptide Copolymer for the Treatment of Multiple Sclerosis

Identification of HLA Class II-Restricted Determinants of Mycobacterium tuberculosis-Derived Proteins by Using HLA-Transgenic, Class II-Deficient Mice

Critical residues on HLA-DRB10402 HV3 peptide for HLA-DQ8-restricted immunogenicity: implications for rheumatoid arthritis predisposition

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