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Bile Acids Activated Receptors Regulate Innate Immunity

Frontiers in immunology, 2018-08, Vol.9, p.1853-1853

2018

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The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis

The Journal of immunology (1950), 2017-07, Vol.199 (2), p.718-733

2017

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Bile acid-activated receptors and the regulation of macrophages function in metabolic disorders

Current opinion in pharmacology, 2020-08, Vol.53, p.45-54

2020

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Theonella : A Treasure Trove of Structurally Unique and Biologically Active Sterols

Marine drugs, 2023-05, Vol.21 (5), p.291

2023

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Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1

PloS one, 2015-11, Vol.10 (11), p.e0141082-e0141082

2015

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Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain

Frontiers in chemistry, 2020-10, Vol.8, p.572885-572885

2020

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The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation

PloS one, 2013-01, Vol.8 (1), p.e54472

2013

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Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH

Scientific reports, 2023-01, Vol.13 (1), p.1602-1602, Article 1602

2023

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The bile acid activated receptors GPBAR1 and FXR exert antagonistic effects on autophagy

The FASEB journal, 2021-01, Vol.35 (1), p.e21271-n/a

2021

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Design, Synthesis, and Biological Evaluation of Potent Dual Agonists of Nuclear and Membrane Bile Acid Receptors

Journal of medicinal chemistry, 2014-02, Vol.57 (3), p.937-954

2014

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Discovering New G-Quadruplex DNA Catalysts in Enantioselective Sulfoxidation Reaction

International journal of molecular sciences, 2022-01, Vol.23 (3), p.1092

2022

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Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists

Molecules (Basel, Switzerland), 2023-03, Vol.28 (6), p.2840

2023

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Development of FXR, PXR and CAR agonists and antagonists for treatment of liver disorders

Current topics in medicinal chemistry, 2012-03, Vol.12 (6), p.605

2012

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Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists

Scientific reports, 2016-01, Vol.6 (1), p.19008-19008, Article 19008

2016

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Next-Generation Sequencing Analysis of Gastric Cancer Identifies the Leukemia Inhibitory Factor Receptor as a Driving Factor in Gastric Cancer Progression and as a Predictor of Poor Prognosis

Frontiers in oncology, 2022-06, Vol.12, p.939969-939969

2022

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Analysis of Gastric Cancer Transcriptome Allows the Identification of Histotype Specific Molecular Signatures With Prognostic Potential

Frontiers in oncology, 2021-05, Vol.11, p.663771-663771

2021

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Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists

ACS medicinal chemistry letters, 2019-04, Vol.10 (4), p.504-510

2019

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Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation

Nutrients, 2019-05, Vol.11 (5), p.1132

2019

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Binding Mechanism of the Farnesoid X Receptor Marine Antagonist Suvanine Reveals a Strategy To Forestall Drug Modulation on Nuclear Receptors. Design, Synthesis, and Biological Evaluation of Novel Ligands

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4701-4717

2013

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Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition

The FASEB journal, 2012-07, Vol.26 (7), p.3021-3031

2012

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Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism

Scientific reports, 2015-11, Vol.5 (1), p.16605-16605, Article 16605

2015

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Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma

Frontiers in oncology, 2023-03, Vol.13, p.1140730-1140730

2023

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Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis

PloS one, 2012-01, Vol.7 (1), p.e30443-e30443

2012

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Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease

Frontiers in pharmacology, 2022-04, Vol.13, p.858137-858137

2022

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BAR502/fibrate conjugates: synthesis, biological evaluation and metabolic profile

Frontiers in chemistry, 2024-07, Vol.12

2024

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Bile Acids Activated Receptors Regulate Innate Immunity

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis

Bile acid-activated receptors and the regulation of macrophages function in metabolic disorders

Theonella : A Treasure Trove of Structurally Unique and Biologically Active Sterols

Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1

Hijacking SARS-CoV-2/ACE2 Receptor Interaction by Natural and Semi-synthetic Steroidal Agents Acting on Functional Pockets on the Receptor Binding Domain

The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation

Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH

The bile acid activated receptors GPBAR1 and FXR exert antagonistic effects on autophagy

Design, Synthesis, and Biological Evaluation of Potent Dual Agonists of Nuclear and Membrane Bile Acid Receptors

Discovering New G-Quadruplex DNA Catalysts in Enantioselective Sulfoxidation Reaction

Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists

Development of FXR, PXR and CAR agonists and antagonists for treatment of liver disorders

Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists

Next-Generation Sequencing Analysis of Gastric Cancer Identifies the Leukemia Inhibitory Factor Receptor as a Driving Factor in Gastric Cancer Progression and as a Predictor of Poor Prognosis

Analysis of Gastric Cancer Transcriptome Allows the Identification of Histotype Specific Molecular Signatures With Prognostic Potential

Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists

Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation

Binding Mechanism of the Farnesoid X Receptor Marine Antagonist Suvanine Reveals a Strategy To Forestall Drug Modulation on Nuclear Receptors. Design, Synthesis, and Biological Evaluation of Novel Ligands

Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition

Structure-based drug design targeting the cell membrane receptor GPBAR1: exploiting the bile acid scaffold towards selective agonism

Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis

Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease

BAR502/fibrate conjugates: synthesis, biological evaluation and metabolic profile

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