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Next-generation Fc receptor–targeting biologics for autoimmune diseases

Autoimmunity reviews, 2019-10, Vol.18 (10), p.102366, Article 102366

2019

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Analysis and functional consequences of increased Fab-sialylation of intravenous immunoglobulin (IVIG) after lectin fractionation

PloS one, 2012-06, Vol.7 (6), p.e37243-e37243

2012

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Therapeutic effect of IVIG on inflammatory arthritis in mice is dependent on the Fc portion and independent of sialylation or basophils

The Journal of immunology (1950), 2014-06, Vol.192 (11), p.5031-5038

2014

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Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats and non-human primates

Respiratory research, 2019-05, Vol.20 (1), p.99-16, Article 99

2019

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Using the K/BxN mouse model of endogenous, chronic, rheumatoid arthritis for the evaluation of potential immunoglobulin-based therapeutic agents, including IVIg and Fc-μTP-L309C, a recombinant IgG1 Fc hexamer

BMC immunology, 2019-12, Vol.20 (1), p.44-44, Article 44

2019

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Preclinical In Vitro and In Vivo Characterization of the Fully Human Monoclonal IgM Antibody KBPA101 Specific for Pseudomonas aeruginosa Serotype IATS-O11

Antimicrobial Agents and Chemotherapy, 2010-06, Vol.54 (6), p.2338-2344

2010

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Nasal-Associated Lymphoid Tissue Is a Mucosal Inductive Site for Virus-Specific Humoral and Cellular Immune Responses

The Journal of immunology (1950), 2002-02, Vol.168 (4), p.1796-1803

2002

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Pharmacokinetics and Safety Profile of the Human Anti-Pseudomonas aeruginosa Serotype O11 Immunoglobulin M Monoclonal Antibody KBPA-101 in Healthy Volunteers

Antimicrobial Agents and Chemotherapy, 2009-08, Vol.53 (8), p.3442-3446

2009

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IVIG in autoimmune disease – Potential next generation biologics

Autoimmunity reviews, 2016-08, Vol.15 (8), p.781-785

2016

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Intravenous immunoglobulin (IVIG) promotes brain repair and improves cognitive outcomes after traumatic brain injury in a FcγRIIB receptor-dependent manner

Brain, behavior, and immunity, 2023-03, Vol.109, p.37-50

2023

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Reversal of Arthritis by Human Monomeric IgA Through the Receptor‐Mediated SH2 Domain–Containing Phosphatase 1 Inhibitory Pathway

Arthritis & rheumatology (Hoboken, N.J.), 2015-07, Vol.67 (7), p.1766-1777

2015

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Human Plasma-derived Polymeric IgA and IgM Antibodies Associate with Secretory Component to Yield Biologically Active Secretory-like Antibodies

The Journal of biological chemistry, 2013-02, Vol.288 (6), p.4085-4094

2013

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rIgG1 Fc Hexamer Inhibits Antibody-Mediated Autoimmune Disease via Effects on Complement and FcγRs

The Journal of immunology (1950), 2018-04, Vol.200 (8), p.2542-2553

2018

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A novel soluble complement receptor 1 fragment with enhanced therapeutic potential

The Journal of biological chemistry, 2021-01, Vol.296, p.100200, Article 100200

2021

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Human IgA Fc receptor FcαRI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment

The Journal of immunology (1950), 2014-12, Vol.193 (11), p.5649-5659

2014

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Distinctive anti-allergy properties of two probiotic bacterial strains in a mouse model of allergic poly-sensitization

Vaccine, 2011-02, Vol.29 (10), p.1981-1990

2011

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Dietary supplementation with Bifidobacterium lactis NCC2818 from weaning reduces local immunoglobulin production in lymphoid-associated tissues but increases systemic antibodies in healthy neonates

British journal of nutrition, 2013-10, Vol.110 (7), p.1243-1252

2013

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Topical application of human-derived Ig isotypes for the control of acute respiratory infection evaluated in a human CD89-expressing mouse model

Mucosal immunology, 2019-07, Vol.12 (4), p.1013-1024

2019

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Characterization of Candidate Anti-Allergic Probiotic Strains in a Model of Th2-Skewed Human Peripheral Blood Mononuclear Cells

International archives of allergy and immunology, 2013-05, Vol.161 (2), p.142-154

2013

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Structural and functional differences between putative mucosal inductive sites of the rat

European journal of immunology, 2002-11, Vol.32 (11), p.3191-3196

2002

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Distinct Mechanisms for Cross-Protection of the Upper Versus Lower Respiratory Tract Through Intestinal Priming

The Journal of immunology (1950), 2002-10, Vol.169 (7), p.3920-3925

2002

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B1 Cells Contribute to Serum IgM, But Not to Intestinal IgA, Production in Gnotobiotic Ig Allotype Chimeric Mice

The Journal of immunology (1950), 2003-05, Vol.170 (9), p.4564-4571

2003

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Food products and allergy development, prevention and treatment

Current opinion in biotechnology, 2006-04, Vol.17 (2), p.198-203

2006

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Recombinant Lactobacillus johnsonii as a mucosal vaccine delivery vehicle

Vaccine, 2002-07, Vol.20 (23), p.2913-2920

2002

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Upper Respiratory Tract Immunity

Viral immunology, 2003-01, Vol.16 (3), p.279-289

Zuercher, Adrian W.

2003

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Next-generation Fc receptor–targeting biologics for autoimmune diseases

Analysis and functional consequences of increased Fab-sialylation of intravenous immunoglobulin (IVIG) after lectin fractionation

Therapeutic effect of IVIG on inflammatory arthritis in mice is dependent on the Fc portion and independent of sialylation or basophils

Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats and non-human primates

Using the K/BxN mouse model of endogenous, chronic, rheumatoid arthritis for the evaluation of potential immunoglobulin-based therapeutic agents, including IVIg and Fc-μTP-L309C, a recombinant IgG1 Fc hexamer

Preclinical In Vitro and In Vivo Characterization of the Fully Human Monoclonal IgM Antibody KBPA101 Specific for Pseudomonas aeruginosa Serotype IATS-O11

Nasal-Associated Lymphoid Tissue Is a Mucosal Inductive Site for Virus-Specific Humoral and Cellular Immune Responses

Pharmacokinetics and Safety Profile of the Human Anti-Pseudomonas aeruginosa Serotype O11 Immunoglobulin M Monoclonal Antibody KBPA-101 in Healthy Volunteers

IVIG in autoimmune disease – Potential next generation biologics

Intravenous immunoglobulin (IVIG) promotes brain repair and improves cognitive outcomes after traumatic brain injury in a FcγRIIB receptor-dependent manner

Reversal of Arthritis by Human Monomeric IgA Through the Receptor‐Mediated SH2 Domain–Containing Phosphatase 1 Inhibitory Pathway

Human Plasma-derived Polymeric IgA and IgM Antibodies Associate with Secretory Component to Yield Biologically Active Secretory-like Antibodies

rIgG1 Fc Hexamer Inhibits Antibody-Mediated Autoimmune Disease via Effects on Complement and FcγRs

A novel soluble complement receptor 1 fragment with enhanced therapeutic potential

Human IgA Fc receptor FcαRI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment

Distinctive anti-allergy properties of two probiotic bacterial strains in a mouse model of allergic poly-sensitization

Dietary supplementation with Bifidobacterium lactis NCC2818 from weaning reduces local immunoglobulin production in lymphoid-associated tissues but increases systemic antibodies in healthy neonates

Topical application of human-derived Ig isotypes for the control of acute respiratory infection evaluated in a human CD89-expressing mouse model

Characterization of Candidate Anti-Allergic Probiotic Strains in a Model of Th2-Skewed Human Peripheral Blood Mononuclear Cells

Structural and functional differences between putative mucosal inductive sites of the rat

Distinct Mechanisms for Cross-Protection of the Upper Versus Lower Respiratory Tract Through Intestinal Priming

B1 Cells Contribute to Serum IgM, But Not to Intestinal IgA, Production in Gnotobiotic Ig Allotype Chimeric Mice

Food products and allergy development, prevention and treatment

Recombinant Lactobacillus johnsonii as a mucosal vaccine delivery vehicle

Upper Respiratory Tract Immunity

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