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Aging, Arterial Stiffness, and Hypertension

Hypertension (Dallas, Tex. 1979), 2015-02, Vol.65 (2), p.252-256

Sun, Zhongjie

2015

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Molecular Basis of Klotho: From Gene to Function in Aging

Endocrine reviews, 2015-04, Vol.36 (2), p.174-193

2015

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Memory T cells: strategies for optimizing tumor immunotherapy

Protein & cell, 2020-08, Vol.11 (8), p.549-564

2020

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Current views on type 2 diabetes

Journal of endocrinology, 2010-01, Vol.204 (1), p.1-11

2010

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Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway

Circulation research, 2021-02, Vol.128 (4), p.492-507

2021

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Activation of DNA demethylases attenuates aging‐associated arterial stiffening and hypertension

Aging cell, 2018-08, Vol.17 (4), p.e12762-n/a

2018

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Molecular mechanisms of pulmonary arterial remodeling

Molecular medicine (Cambridge, Mass.), 2014-01, Vol.20 (1), p.191-201

2014

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Klotho Gene Delivery Prevents the Progression of Spontaneous Hypertension and Renal Damage

Hypertension (Dallas, Tex. 1979), 2009-10, Vol.54 (4), p.810-817

2009

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Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension

Journal of hypertension, 2010-02, Vol.28 (2), p.201-212

2010

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Klotho gene deficiency causes salt-sensitive hypertension via monocyte chemotactic protein-1/CC chemokine receptor 2-mediated inflammation

Journal of the American Society of Nephrology, 2015-01, Vol.26 (1), p.121-132

2015

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Activation of SIRT1 Attenuates Klotho Deficiency–Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity

Hypertension (Dallas, Tex. 1979), 2016-11, Vol.68 (5), p.1191-1199

2016

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Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1

Hypertension (Dallas, Tex. 1979), 2018-05, Vol.71 (5), p.877-885

2018

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Estrogen inhibits renal Na-Pi Co-transporters and improves klotho deficiency-induced acute heart failure

Redox biology, 2021-11, Vol.47, p.102173-102173, Article 102173

2021

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Inhibition of miR-101-3p prevents human aortic valve interstitial cell calcification through regulation of CDH11/SOX9 expression

Molecular medicine (Cambridge, Mass.), 2023-02, Vol.29 (1), p.24-24, Article 24

2023

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Antiaging Gene Klotho Enhances Glucose-Induced Insulin Secretion by Up-Regulating Plasma Membrane Levels of TRPV2 in MIN6 β-Cells

Endocrinology (Philadelphia), 2012-07, Vol.153 (7), p.3029-3039

2012

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Inhibition of Phosphodiesterase-1 Attenuates Cold-Induced Pulmonary Hypertension

Hypertension (Dallas, Tex. 1979), 2013-03, Vol.61 (3), p.585-592

2013

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Monocrotaline-Induced Pulmonary Hypertension Involves Downregulation of Antiaging Protein Klotho and eNOS Activity

Hypertension (Dallas, Tex. 1979), 2016-11, Vol.68 (5), p.1255-1263

2016

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Thyroid hormone potentiates insulin  signaling and attenuates hyperglycemia and insulin resistance in a mouse model of type 2 diabetes

British journal of pharmacology, 2011-02, Vol.162 (3), p.597-610

2011

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Ribonucleic Acid Interference Knockdown of Interleukin 6 Attenuates Cold-Induced Hypertension

Hypertension (Dallas, Tex. 1979), 2010-06, Vol.55 (6), p.1484-1491

2010

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Genetic Deficiency of Anti-Aging Gene Klotho Exacerbates Early Nephropathy in STZ-Induced Diabetes in Male Mice

Endocrinology (Philadelphia), 2013-10, Vol.154 (10), p.3855-3863

2013

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TNFα Induces DNA and Histone Hypomethylation and Pulmonary Artery Smooth Muscle Cell Proliferation Partly via Excessive Superoxide Formation

Antioxidants, 2024-05, Vol.13 (6), p.677

2024

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In vivo AAV delivery of glutathione reductase gene attenuates anti-aging gene klotho deficiency-induced kidney damage

Redox biology, 2020-10, Vol.37, p.101692-101692, Article 101692

2020

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Adult Mouse Kidney Stem Cells Orchestrate the De Novo Assembly of a Nephron via Sirt2‐Modulated Canonical Wnt/β‐Catenin Signaling

Advanced science, 2022-05, Vol.9 (15), p.e2104034-n/a

2022

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Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP‐PKA pathway

Aging cell, 2012-06, Vol.11 (3), p.410-417

2012

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Targeting ferroptosis in treating traumatic brain injury: Harnessing the power of traditional Chinese medicine

Biomedicine & pharmacotherapy, 2024-11, Vol.180, p.117555, Article 117555

2024

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Aging, Arterial Stiffness, and Hypertension

Molecular Basis of Klotho: From Gene to Function in Aging

Memory T cells: strategies for optimizing tumor immunotherapy

Current views on type 2 diabetes

Klotho Deficiency Causes Heart Aging via Impairing the Nrf2-GR Pathway

Activation of DNA demethylases attenuates aging‐associated arterial stiffening and hypertension

Molecular mechanisms of pulmonary arterial remodeling

Klotho Gene Delivery Prevents the Progression of Spontaneous Hypertension and Renal Damage

Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension

Klotho gene deficiency causes salt-sensitive hypertension via monocyte chemotactic protein-1/CC chemokine receptor 2-mediated inflammation

Activation of SIRT1 Attenuates Klotho Deficiency–Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity

Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1

Estrogen inhibits renal Na-Pi Co-transporters and improves klotho deficiency-induced acute heart failure

Inhibition of miR-101-3p prevents human aortic valve interstitial cell calcification through regulation of CDH11/SOX9 expression

Antiaging Gene Klotho Enhances Glucose-Induced Insulin Secretion by Up-Regulating Plasma Membrane Levels of TRPV2 in MIN6 β-Cells

Inhibition of Phosphodiesterase-1 Attenuates Cold-Induced Pulmonary Hypertension

Monocrotaline-Induced Pulmonary Hypertension Involves Downregulation of Antiaging Protein Klotho and eNOS Activity

Thyroid hormone potentiates insulin  signaling and attenuates hyperglycemia and insulin resistance in a mouse model of type 2 diabetes

Ribonucleic Acid Interference Knockdown of Interleukin 6 Attenuates Cold-Induced Hypertension

Genetic Deficiency of Anti-Aging Gene Klotho Exacerbates Early Nephropathy in STZ-Induced Diabetes in Male Mice

TNFα Induces DNA and Histone Hypomethylation and Pulmonary Artery Smooth Muscle Cell Proliferation Partly via Excessive Superoxide Formation

In vivo AAV delivery of glutathione reductase gene attenuates anti-aging gene klotho deficiency-induced kidney damage

Adult Mouse Kidney Stem Cells Orchestrate the De Novo Assembly of a Nephron via Sirt2‐Modulated Canonical Wnt/β‐Catenin Signaling

Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP‐PKA pathway

Targeting ferroptosis in treating traumatic brain injury: Harnessing the power of traditional Chinese medicine

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