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Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Cancer research (Chicago, Ill.), 2008-04, Vol.68 (7), p.2366-2374

2008

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A Multicentre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Sirukumab in the Treatment of Giant Cell Arteritis

Rheumatology and therapy., 2020-12, Vol.7 (4), p.793-810

2020

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GSK1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models

Molecular cancer therapeutics, 2009-07, Vol.8 (7), p.1808-1817

2009

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Defining Balanced Conditions for Inhibitor Screening Assays That Target Bisubstrate Enzymes

Journal of biomolecular screening, 2009-02, Vol.14 (2), p.111-120

2009

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C-terminal region of USP7/HAUSP is critical for deubiquitination activity and contains a second mdm2/p53 binding site

Archives of biochemistry and biophysics, 2010-11, Vol.503 (2), p.207-212

2010

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A Biochemical Rationale for the Anticancer Effects of Hsp90 Inhibitors: Slow, Tight Binding Inhibition by Geldanamycin and Its Analogues

Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (20), p.7625-7630

2006

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Evidence for allosteric interactions of antagonist binding to the smoothened receptor

The Journal of pharmacology and experimental therapeutics, 2009-06, Vol.329 (3), p.995

2009

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Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase

Journal of medicinal chemistry, 2010-05, Vol.53 (10), p.3973-4001

2010

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Characterization of the Transthyretin Acid Denaturation Pathways by Analytical Ultracentrifugation: Implications for Wild-Type, V30M, and L55P Amyloid Fibril Formation

Biochemistry (Easton), 1998-12, Vol.37 (51), p.17851-17864

1998

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Human mdm2 Mediates Multiple Mono-ubiquitination of p53 by a Mechanism Requiring Enzyme Isomerization

The Journal of biological chemistry, 2001-08, Vol.276 (33), p.31357-31367

2001

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Matrix metalloproteinase–activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity

Molecular cancer therapeutics, 2005-05, Vol.4 (5), p.751-760

2005

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Differentiation of Hdm2-Mediated p53 Ubiquitination and Hdm2 Autoubiquitination Activity by Small Molecular Weight Inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2002-11, Vol.99 (23), p.14734-14739

2002

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Inhibiting Transthyretin Amyloid Fibril Formation Via Protein Stabilization

Proceedings of the National Academy of Sciences - PNAS, 1996-12, Vol.93 (26), p.15051-15056

1996

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Protein subunit interactions and structural integrity of amyloidogenic transthyretins: evidence from electrospray mass spectrometry

Journal of molecular biology, 1998-08, Vol.281 (3), p.553-564

1998

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The catalytic role of INCENP in Aurora B activation and the kinetic mechanism of Aurora B/INCENP

Biochemical journal, 2009-01, Vol.417 (1), p.355-360

2009

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2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.679-683

2010

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2,3,5-Trisubstituted pyridines as selective AKT inhibitors—Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.673-678

2010

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Tetrasubstituted pyridines as potent and selective AKT inhibitors: Reduced CYP450 and hERG inhibition of aminopyridines

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.684-688

2010

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Key design considerations on comparative clinical efficacy studies for biosimilars: adalimumab as an example

RMD Open, 2016-01, Vol.2 (1), p.e000154-e000154

2016

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Phylogenomic and Biochemical Characterization of Three Legionella pneumophila Polypeptide Deformylases

Journal of Bacteriology, 2006-07, Vol.188 (14), p.5249-5257

2006

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Modulation of kinase‐inhibitor interactions by auxiliary protein binding: Crystallography studies on Aurora A interactions with VX‐680 and with TPX2

Protein science, 2008-10, Vol.17 (10), p.1791-1797

2008

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A simple method for predicting serum protein binding of compounds from IC50 shift analysis for in vitro assays

Bioorganic & medicinal chemistry letters, 2004-05, Vol.14 (9), p.2309-2312

2004

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Suppression of nonlinear panel flutter with piezoelectric actuators using finite element method

AIAA journal, 1995-06, Vol.33 (6), p.1098-1105

1995

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The Acid-Mediated Denaturation Pathway of Transthyretin Yields a Conformational Intermediate That Can Self-Assemble into Amyloid

Biochemistry (Easton), 1996-05, Vol.35 (20), p.6470-6482

1996

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Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

A Multicentre, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Sirukumab in the Treatment of Giant Cell Arteritis

GSK1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models

Defining Balanced Conditions for Inhibitor Screening Assays That Target Bisubstrate Enzymes

C-terminal region of USP7/HAUSP is critical for deubiquitination activity and contains a second mdm2/p53 binding site

A Biochemical Rationale for the Anticancer Effects of Hsp90 Inhibitors: Slow, Tight Binding Inhibition by Geldanamycin and Its Analogues

Evidence for allosteric interactions of antagonist binding to the smoothened receptor

Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase

Characterization of the Transthyretin Acid Denaturation Pathways by Analytical Ultracentrifugation: Implications for Wild-Type, V30M, and L55P Amyloid Fibril Formation

Human mdm2 Mediates Multiple Mono-ubiquitination of p53 by a Mechanism Requiring Enzyme Isomerization

Matrix metalloproteinase–activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity

Differentiation of Hdm2-Mediated p53 Ubiquitination and Hdm2 Autoubiquitination Activity by Small Molecular Weight Inhibitors

Inhibiting Transthyretin Amyloid Fibril Formation Via Protein Stabilization

Protein subunit interactions and structural integrity of amyloidogenic transthyretins: evidence from electrospray mass spectrometry

The catalytic role of INCENP in Aurora B activation and the kinetic mechanism of Aurora B/INCENP

2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles

2,3,5-Trisubstituted pyridines as selective AKT inhibitors—Part I: Substitution at 2-position of the core pyridine for ROCK1 selectivity

Tetrasubstituted pyridines as potent and selective AKT inhibitors: Reduced CYP450 and hERG inhibition of aminopyridines

Key design considerations on comparative clinical efficacy studies for biosimilars: adalimumab as an example

Phylogenomic and Biochemical Characterization of Three Legionella pneumophila Polypeptide Deformylases

Modulation of kinase‐inhibitor interactions by auxiliary protein binding: Crystallography studies on Aurora A interactions with VX‐680 and with TPX2

A simple method for predicting serum protein binding of compounds from IC50 shift analysis for in vitro assays

Suppression of nonlinear panel flutter with piezoelectric actuators using finite element method

Identification of 4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a Novel Inhibitor of AKT Kinase

The Acid-Mediated Denaturation Pathway of Transthyretin Yields a Conformational Intermediate That Can Self-Assemble into Amyloid

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