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Chemical Modification and Site-directed Mutagenesis of Cysteine Residues in Human Placental S-Adenosylhomocysteine Hydrolase

The Journal of biological chemistry, 1996-11, Vol.271 (45), p.28009-28016

1996

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A Novel Mechanism-based Inhibitor (6â²-Bromo-5â²,6â²-didehydro-6â²-deoxy-6â²-fluorohomoadenosine) That Covalently Modifies Human Placental S-Adenosylhomocysteine Hydrolase

The Journal of biological chemistry, 1998-07, Vol.273 (29), p.18191-18197

1998

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Phosphate Prodrugs for Amines Utilizing a Fast Intramolecular Hydroxy Amide Lactonization

Journal of organic chemistry, 1996-11, Vol.61 (24), p.8636-8641

1996

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Mechanism of inactivation of S-adenosylhomocysteine hydrolase by (Z)-4',5'-didehydro-5'-deoxy-5'-fluoroadenosine

The Journal of biological chemistry, 1993-08, Vol.268 (23), p.17030-17037

1993

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S-Adenosyl-L-homocysteine hydrolase inhibitor mediates immunosuppressive effects in vivo: suppression of delayed type hypersensitivity ear swelling and peptidoglycan polysaccharide-induced arthritis

The Journal of pharmacology and experimental therapeutics, 2001-01, Vol.296 (1), p.106

2001

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Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength

Nature structural biology, 1998-05, Vol.5 (5), p.369-376

1998

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Inactivation of S-Adenosyl-l-homocysteine Hydrolase and Antiviral Activity with 5‘,5‘,6‘,6‘-Tetradehydro-6‘-deoxy-6‘-halohomoadenosine Analogues (4‘-Haloacetylene Analogues Derived from Adenosine)

Journal of medicinal chemistry, 1998-09, Vol.41 (20), p.3857-3864

1998

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Anticancer and Antiviral Effects and Inactivation of S-Adenosyl-l-homocysteine Hydrolase with 5‘-Carboxaldehydes and Oximes Synthesized from Adenosine and Sugar-Modified Analogues

Journal of medicinal chemistry, 1997-05, Vol.40 (11), p.1608-1618

1997

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Nucleic Acid-Related Compounds. 84. Synthesis of 6'-(E and Z)-Halohomovinyl Derivatives of Adenosine, Inactivation of S-Adenosyl-L-homocysteine Hydrolase, and Correlation of Anticancer and Antiviral Potencies with Enzyme Inhibition

Journal of medicinal chemistry, 1994-10, Vol.37 (21), p.3579-3587

1994

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Discovery of Type II (Covalent) Inactivation of S-Adenosyl-l-homocysteine Hydrolase Involving Its “Hydrolytic Activity”: Synthesis and Evaluation of Dihalohomovinyl Nucleoside Analogues Derived from Adenosine

Journal of medicinal chemistry, 1998-07, Vol.41 (16), p.3078-3083

1998

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An Enzymatic Method Designed to Differentiate between Fresh and Frozen-thawed Fish

Journal of food science, 1990-01, Vol.55 (1), p.74-76

1990

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Open-Chain Carbocyclic Analogs of Adenosine with Dihalovinyl Unit as Potential Inhibitors of S-Adenosyl-L-homocysteine Hydrolase

Nucleosides, nucleotides & nucleic acids, 2003-10, Vol.22 (9), p.1747-1755

2003

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Photoaffinity Labeling of Human Placental S-Adenosylhomocysteine Hydrolase with [2-3H]8-Azido-adenosine

The Journal of biological chemistry, 1995-07, Vol.270 (27), p.16140-16146

1995

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Aristeromycin-5‘-carboxaldehyde: A Potent Inhibitor of S-Adenosyl- l-homocysteine Hydrolase

Journal of medicinal chemistry, 1996-06, Vol.39 (12), p.2347-2353

1996

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Nucleic Acid Related Compounds. 80. Synthesis of 5'-S-(Alkyl and aryl)-5'-fluoro-5'-thioadenosines with Xenon Difluoride or (Diethylamido)sulfur Trifluoride, Hydrolysis in Aqueous Buffer, and Inhibition of S-Adenosyl-L-homocysteine hydrolase by derived "Adenosine 5'-Aldehyde" Species

Journal of organic chemistry, 1994-02, Vol.59 (3), p.544-555

1994

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(E)-5',6'-Didehydro-6'-deoxy-6'-fluorohomoadenosine: A Substrate That Measures the Hydrolytic Activity of S-Adenosylhomocysteine Hydrolase

Biochemistry (Easton), 1994-10, Vol.33 (40), p.12305-12311

1994

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Purification and properties of neutral β- N-acetylglycosaminidase from carp blood

Biochimica et biophysica acta. General subjects, 1991-05, Vol.1074 (1), p.79-84

1991

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Inactivation of S-Adenosyl-l-homocysteine Hydrolase by Amide and Ester Derivatives of Adenosine-5‘-carboxylic Acid

Journal of medicinal chemistry, 1996-10, Vol.39 (21), p.4162-4166

1996

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Mechanism of Inactivation of S-Adenosylhomocysteine Hydrolase by (E)-5',6'-Didehydro-6'-deoxy-6'-halohomoadenosines

Biochemistry (Easton), 1994-03, Vol.33 (12), p.3758-3765

1994

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Effect of limited proteolysis on the stability and enzymatic activity of human placental S‐adenosylhomocysteine hydrolase

Protein science, 1997-07, Vol.6 (7), p.1482-1490

1997

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Oligosaccharidase activity of a neutral beta-N-acetylglucosaminidase from carp blood

Nippon Suisan Gakkaishi, 1991, Vol.57 (2), p.325-328

1991

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Effects of 4'-modified analogs of aristeromycin on the metabolism of S-adenosyl-L-homocysteine in murine L929 cells

Molecular pharmacology, 1993-06, Vol.43 (6), p.989-997

1993

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Ligand-dependent changes in intrinsic fluorescence of S-adenosylhomocysteine hydrolase: Implications for the mechanism of inhibitor-induced inhibition

Biochemistry (Easton), 1993-10, Vol.32 (39), p.10414-10422

1993

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Synthesis of Homologated Halovinyl Derivatives from Aristeromycin and Their Inhibition of Human Placental S-Adenosyl-L-homocysteine Hydrolase

Nucleosides & nucleotides, 1998-01, Vol.17 (1-3), p.99-113

1998

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Design and synthesis of S-adenosylhomocysteine hydrolase inhibitors as broad-spectrum antiviral agents

Advances in Antiviral Drug Design, 1996, Vol.2, p.41-88

1996

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Chemical Modification and Site-directed Mutagenesis of Cysteine Residues in Human Placental S-Adenosylhomocysteine Hydrolase

A Novel Mechanism-based Inhibitor (6â²-Bromo-5â²,6â²-didehydro-6â²-deoxy-6â²-fluorohomoadenosine) That Covalently Modifies Human Placental S-Adenosylhomocysteine Hydrolase

Phosphate Prodrugs for Amines Utilizing a Fast Intramolecular Hydroxy Amide Lactonization

Mechanism of inactivation of S-adenosylhomocysteine hydrolase by (Z)-4',5'-didehydro-5'-deoxy-5'-fluoroadenosine

S-Adenosyl-L-homocysteine hydrolase inhibitor mediates immunosuppressive effects in vivo: suppression of delayed type hypersensitivity ear swelling and peptidoglycan polysaccharide-induced arthritis

Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength

Inactivation of S-Adenosyl-l-homocysteine Hydrolase and Antiviral Activity with 5‘,5‘,6‘,6‘-Tetradehydro-6‘-deoxy-6‘-halohomoadenosine Analogues (4‘-Haloacetylene Analogues Derived from Adenosine)

Anticancer and Antiviral Effects and Inactivation of S-Adenosyl-l-homocysteine Hydrolase with 5‘-Carboxaldehydes and Oximes Synthesized from Adenosine and Sugar-Modified Analogues

Nucleic Acid-Related Compounds. 84. Synthesis of 6'-(E and Z)-Halohomovinyl Derivatives of Adenosine, Inactivation of S-Adenosyl-L-homocysteine Hydrolase, and Correlation of Anticancer and Antiviral Potencies with Enzyme Inhibition

Discovery of Type II (Covalent) Inactivation of S-Adenosyl-l-homocysteine Hydrolase Involving Its “Hydrolytic Activity”: Synthesis and Evaluation of Dihalohomovinyl Nucleoside Analogues Derived from Adenosine

An Enzymatic Method Designed to Differentiate between Fresh and Frozen-thawed Fish

Open-Chain Carbocyclic Analogs of Adenosine with Dihalovinyl Unit as Potential Inhibitors of S-Adenosyl-L-homocysteine Hydrolase

Photoaffinity Labeling of Human Placental S-Adenosylhomocysteine Hydrolase with [2-3H]8-Azido-adenosine

Aristeromycin-5‘-carboxaldehyde: A Potent Inhibitor of S-Adenosyl- l-homocysteine Hydrolase

Nucleic Acid Related Compounds. 80. Synthesis of 5'-S-(Alkyl and aryl)-5'-fluoro-5'-thioadenosines with Xenon Difluoride or (Diethylamido)sulfur Trifluoride, Hydrolysis in Aqueous Buffer, and Inhibition of S-Adenosyl-L-homocysteine hydrolase by derived "Adenosine 5'-Aldehyde" Species

(E)-5',6'-Didehydro-6'-deoxy-6'-fluorohomoadenosine: A Substrate That Measures the Hydrolytic Activity of S-Adenosylhomocysteine Hydrolase

Purification and properties of neutral β- N-acetylglycosaminidase from carp blood

Inactivation of S-Adenosyl-l-homocysteine Hydrolase by Amide and Ester Derivatives of Adenosine-5‘-carboxylic Acid

Mechanism of Inactivation of S-Adenosylhomocysteine Hydrolase by (E)-5',6'-Didehydro-6'-deoxy-6'-halohomoadenosines

Effect of limited proteolysis on the stability and enzymatic activity of human placental S‐adenosylhomocysteine hydrolase

Oligosaccharidase activity of a neutral beta-N-acetylglucosaminidase from carp blood

Effects of 4'-modified analogs of aristeromycin on the metabolism of S-adenosyl-L-homocysteine in murine L929 cells

Ligand-dependent changes in intrinsic fluorescence of S-adenosylhomocysteine hydrolase: Implications for the mechanism of inhibitor-induced inhibition

Synthesis of Homologated Halovinyl Derivatives from Aristeromycin and Their Inhibition of Human Placental S-Adenosyl-L-homocysteine Hydrolase

Design and synthesis of S-adenosylhomocysteine hydrolase inhibitors as broad-spectrum antiviral agents

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