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The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

Medicinal research reviews, 2016-09, Vol.36 (5), p.924-963

2016

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Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications

Free radical biology & medicine, 2021-05, Vol.168, p.129-141

2021

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Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions

Journal of medicinal chemistry, 2016-12, Vol.59 (24), p.10837-10858

2016

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5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress

Free radical biology & medicine, 2019-04, Vol.134, p.288-303

2019

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An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis

Scientific reports, 2016-05, Vol.6 (1), p.26585-26585, Article 26585

2016

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CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation

Redox biology, 2019-09, Vol.26, p.101266-101266, Article 101266

2019

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Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions

European journal of medicinal chemistry, 2020-12, Vol.207, p.112734, Article 112734

2020

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Structure–Activity and Structure–Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1–Nrf2 Protein–Protein Interaction Inhibitor

Journal of medicinal chemistry, 2015-08, Vol.58 (16), p.6410-6421

2015

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Game study on synergistic effect of building supply chain based on blockchain

R.A.I.R.O. Recherche opérationnelle, 2024-02

2024

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Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation

PloS one, 2013-09, Vol.8 (9), p.e75076-e75076

2013

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Discovery and Development of Caffeic Acid Analogs as Versatile Therapeutic Agents

Pharmaceuticals (Basel, Switzerland), 2024-10, Vol.17 (10), p.1403

2024

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Attribute-Aware Loss Function for Accurate Semantic Segmentation Considering the Pedestrian Orientations

IEICE transactions on fundamentals of electronics, communications and computer sciences, 2020-01, Vol.E103.A (1), p.231-242

2020

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Predict Vehicle Collision by TTC From Motion Using a Single Video Camera

IEEE transactions on intelligent transportation systems, 2019-02, Vol.20 (2), p.522-533

2019

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Binding thermodynamics and kinetics guided optimization of potent Keap1–Nrf2 peptide inhibitors

RSC advances, 2015, Vol.5 (105), p.85983-85987

2015

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Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown

Journal of medicinal chemistry, 2020-05, Vol.63 (9), p.4644-4654

2020

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Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors

European journal of medicinal chemistry, 2020-09, Vol.202, p.112532-112532, Article 112532

2020

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3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation

Oxidative medicine and cellular longevity, 2018-01, Vol.2018 (2018), p.1-16

2018

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Polar Recognition Group Study of Keap1-Nrf2 Protein–Protein Interaction Inhibitors

ACS medicinal chemistry letters, 2016-09, Vol.7 (9), p.835-840

2016

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Sequential Semantic Segmentation of Road Profiles for Path and Speed Planning

IEEE transactions on intelligent transportation systems, 2022-12, Vol.23 (12), p.23869-23882

2022

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Nuclear Factor Erythroid 2‑Related Factor 2 (Nrf2) Inhibition: An Emerging Strategy in Cancer Therapy

Journal of medicinal chemistry, 2019-04, Vol.62 (8), p.3840-3856

2019

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Integrated analysis of tertiary lymphoid structures and immune infiltration in ccRCC microenvironment revealed their clinical significances: a multicenter cohort study

Journal for immunotherapy of cancer, 2024-06, Vol.12 (6), p.e008613

2024

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Influence of sugammadex versus neostigmine for neuromuscular block reversal on the incidence of postoperative pulmonary complications: a meta-analysis of randomized controlled trials

Perioperative medicine (London), 2021-09, Vol.10 (1), p.1-32, Article 32

2021

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Novel protein–protein interaction inhibitor of Nrf2–Keap1 discovered by structure-based virtual screening

MedChemComm, 2014, Vol.5 (1), p.93-98

2014

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Design, Synthesis, and Structure–Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1‑Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein–Protein Interaction Inhibitors

Journal of medicinal chemistry, 2020-10, Vol.63 (19), p.11149-11168

2020

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Discovery of Potent Keap1–Nrf2 Protein–Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2736-2745

2014

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The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications

Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions

5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress

An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis

CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation

Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions

Structure–Activity and Structure–Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1–Nrf2 Protein–Protein Interaction Inhibitor

Game study on synergistic effect of building supply chain based on blockchain

Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation

Discovery and Development of Caffeic Acid Analogs as Versatile Therapeutic Agents

Attribute-Aware Loss Function for Accurate Semantic Segmentation Considering the Pedestrian Orientations

Predict Vehicle Collision by TTC From Motion Using a Single Video Camera

Binding thermodynamics and kinetics guided optimization of potent Keap1–Nrf2 peptide inhibitors

Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown

Recent progress in Keap1-Nrf2 protein-protein interaction inhibitors

3-(1H-Benzo[d]imidazol-6-yl)-5-(4-fluorophenyl)-1,2,4-oxadiazole (DDO7232), a Novel Potent Nrf2/ARE Inducer, Ameliorates DSS-Induced Murine Colitis and Protects NCM460 Cells against Oxidative Stress via ERK1/2 Phosphorylation

Polar Recognition Group Study of Keap1-Nrf2 Protein–Protein Interaction Inhibitors

Sequential Semantic Segmentation of Road Profiles for Path and Speed Planning

Nuclear Factor Erythroid 2‑Related Factor 2 (Nrf2) Inhibition: An Emerging Strategy in Cancer Therapy

Integrated analysis of tertiary lymphoid structures and immune infiltration in ccRCC microenvironment revealed their clinical significances: a multicenter cohort study

Influence of sugammadex versus neostigmine for neuromuscular block reversal on the incidence of postoperative pulmonary complications: a meta-analysis of randomized controlled trials

Novel protein–protein interaction inhibitor of Nrf2–Keap1 discovered by structure-based virtual screening

Design, Synthesis, and Structure–Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1‑Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein–Protein Interaction Inhibitors

Discovery of Potent Keap1–Nrf2 Protein–Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis

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