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From micrograms to grams: scale-up synthesis of eribulin mesylate

Natural product reports, 2013-09, Vol.3 (9), p.1158-1164

2013

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Natural Product-Like Virtual Libraries: Recursive Atom-Based Enumeration

Journal of chemical information and modeling, 2011-03, Vol.51 (3), p.541-557

Yu, Melvin J

2011

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Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo

Molecular pharmacology, 2014-03, Vol.85 (3), p.429-440

2014

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Eribulin Induces Irreversible Mitotic Blockade: Implications of Cell-Based Pharmacodynamics for In vivo Efficacy under Intermittent Dosing Conditions

Cancer research (Chicago, Ill.), 2011-01, Vol.71 (2), p.496-505

2011

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Predicting Total Clearance in Humans from Chemical Structure

Journal of chemical information and modeling, 2010-07, Vol.50 (7), p.1284-1295

Yu, Melvin J

2010

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Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389

Cancer research (Chicago, Ill.), 2004-08, Vol.64 (16), p.5760-5766

2004

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Druggable chemical space and enumerative combinatorics

Journal of cheminformatics, 2013-04, Vol.5 (1), p.19-19, Article 19

Yu, Melvin J

2013

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Broad Spectrum Preclinical Antitumor Activity of Eribulin (Halaven®): Optimal Effectiveness under Intermittent Dosing Conditions

Anticancer research, 2012-05, Vol.32 (5), p.1611-1619

2012

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Simulating the drug discovery pipeline: a Monte Carlo approach

Journal of cheminformatics, 2012-11, Vol.4 (1), p.32-32, Article 32

Yu, Melvin J

2012

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Atom-based enumeration: New eribulin analogues with low susceptibility to P-glycoprotein-mediated drug efflux

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7363-7366

2012

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In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B

Cancer research (Chicago, Ill.), 2001-02, Vol.61 (3), p.1013-1021

2001

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Cysteine Deprivation Targets Ovarian Clear Cell Carcinoma Via Oxidative Stress and Iron-Sulfur Cluster Biogenesis Deficit

Antioxidants & redox signaling, 2020-12, Vol.33 (17), p.1191-1208

2020

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Novel second generation analogs of eribulin. Part III: Blood–brain barrier permeability and in vivo activity in a brain tumor model

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1639-1643

2011

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Novel second generation analogs of eribulin. Part I: Compounds containing a lipophilic C32 side chain overcome P-glycoprotein susceptibility

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1630-1633

2011

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Macrocyclic ketone analogues of halichondrin B

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (22), p.5551-5554

2004

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Novel second generation analogs of eribulin. Part II: Orally available and active against resistant tumors in vivo

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1634-1638

2011

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MLL5 is involved in retinal photoreceptor maturation through facilitating CRX-mediated photoreceptor gene transactivation

iScience, 2022-04, Vol.25 (4), p.104058-104058, Article 104058

2022

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Structurally simplified macrolactone analogues of halichondrin B

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (22), p.5547-5550

2004

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Basic approach to optimize the small drug seeds with minimized CV risks on the early stage of drug discovery by using small molecule-based in silico models for prediction of hERG/Nav1.5 inhibitions

Toxicology letters, 2014-09, Vol.229, p.S159-S159

2014

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ChemInform Abstract: From Micrograms to Grams. Scale-up Synthesis of Eribulin Mesylate

ChemInform, 2013-11, Vol.44 (48), p.no-no

2013

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Synthesis and x-ray crystallographic analysis of quinazolinone cholecystokinin/gastrin receptor ligands

Journal of medicinal chemistry, 1992-07, Vol.35 (14), p.2534-2542

1992

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Design and Development of an Intranet-Based IT Asset Management System with Mobile Application

International journal of innovation, management and technology, 2014-12, Vol.5 (6), p.460-464

Mesa, Leonnel

2014

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Benzylamine antioxidants: relationship between structure, peroxyl radical scavenging, lipid peroxidation inhibition and cytoprotection

Journal of medicinal chemistry, 1993-04, Vol.36 (9), p.1262-1271

1993

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Structure-activity relationships of halichondrin B analogues: modifications at C.30-C.38

Bioorganic & medicinal chemistry letters, 2000-05, Vol.10 (10), p.1029-1032

2000

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Quinazolinone cholecystokinin-B receptor ligands

Journal of medicinal chemistry, 1991-04, Vol.34 (4), p.1505-1508

1991

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From micrograms to grams: scale-up synthesis of eribulin mesylate

Natural Product-Like Virtual Libraries: Recursive Atom-Based Enumeration

Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo

Eribulin Induces Irreversible Mitotic Blockade: Implications of Cell-Based Pharmacodynamics for In vivo Efficacy under Intermittent Dosing Conditions

Predicting Total Clearance in Humans from Chemical Structure

Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389

Druggable chemical space and enumerative combinatorics

Broad Spectrum Preclinical Antitumor Activity of Eribulin (Halaven®): Optimal Effectiveness under Intermittent Dosing Conditions

Simulating the drug discovery pipeline: a Monte Carlo approach

Atom-based enumeration: New eribulin analogues with low susceptibility to P-glycoprotein-mediated drug efflux

In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B

Cysteine Deprivation Targets Ovarian Clear Cell Carcinoma Via Oxidative Stress and Iron-Sulfur Cluster Biogenesis Deficit

Novel second generation analogs of eribulin. Part III: Blood–brain barrier permeability and in vivo activity in a brain tumor model

Novel second generation analogs of eribulin. Part I: Compounds containing a lipophilic C32 side chain overcome P-glycoprotein susceptibility

Macrocyclic ketone analogues of halichondrin B

Novel second generation analogs of eribulin. Part II: Orally available and active against resistant tumors in vivo

MLL5 is involved in retinal photoreceptor maturation through facilitating CRX-mediated photoreceptor gene transactivation

Structurally simplified macrolactone analogues of halichondrin B

Basic approach to optimize the small drug seeds with minimized CV risks on the early stage of drug discovery by using small molecule-based in silico models for prediction of hERG/Nav1.5 inhibitions

ChemInform Abstract: From Micrograms to Grams. Scale-up Synthesis of Eribulin Mesylate

Synthesis and x-ray crystallographic analysis of quinazolinone cholecystokinin/gastrin receptor ligands

Design and Development of an Intranet-Based IT Asset Management System with Mobile Application

Benzylamine antioxidants: relationship between structure, peroxyl radical scavenging, lipid peroxidation inhibition and cytoprotection

Structure-activity relationships of halichondrin B analogues: modifications at C.30-C.38

Quinazolinone cholecystokinin-B receptor ligands

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