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Unlocking the Full Potential of SGLT2 Inhibitors: Expanding Applications beyond Glycemic Control

International journal of molecular sciences, 2023-03, Vol.24 (7), p.6039

2023

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Role of Ganetespib, an HSP90 Inhibitor, in Cancer Therapy: From Molecular Mechanisms to Clinical Practice

International journal of molecular sciences, 2023-03, Vol.24 (5), p.5014

2023

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Interference With the AMPKα/mTOR/NLRP3 Signaling and the IL-23/IL-17 Axis Effectively Protects Against the Dextran Sulfate Sodium Intoxication in Rats: A New Paradigm in Empagliflozin and Metformin Reprofiling for the Management of Ulcerative Colitis

Frontiers in pharmacology, 2021-08, Vol.12, p.719984-719984

2021

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Ameliorative Effect of Dabigatran on CFA-Induced Rheumatoid Arthritis via Modulating Kallikrein-Kinin System in Rats

International journal of molecular sciences, 2022-09, Vol.23 (18), p.10297

2022

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Canagliflozin-loaded chitosan-hyaluronic acid microspheres modulate AMPK/NF-κB/NLRP3 axis: A new paradigm in the rectal therapy of ulcerative colitis

Biomedicine & pharmacotherapy, 2022-09, Vol.153, p.113409-113409, Article 113409

2022

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Empagliflozin adjunct with metformin for the inhibition of hepatocellular carcinoma progression: Emerging approach for new application

Biomedicine & pharmacotherapy, 2022-01, Vol.145, p.112455, Article 112455

2022

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α7-nAChRs-mediated therapeutic angiogenesis accounts for the advantageous effect of low nicotine doses against myocardial infarction in rats

European journal of pharmacology, 2021-05, Vol.898, p.173996, Article 173996

2021

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Innovative challenge for the inhibition of hepatocellular carcinoma progression by combined targeting of HSP90 and STAT3/HIF-1α signaling

Biomedicine & pharmacotherapy, 2023-02, Vol.158, p.114196-114196, Article 114196

2023

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Carbocisteine as a Modulator of Nrf2/HO-1 and NFκB Interplay in Rats: New Inspiration for the Revival of an Old Drug for Treating Ulcerative Colitis

Frontiers in pharmacology, 2022-06, Vol.13, p.887233-887233

2022

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Coomassie brilliant blue G-250 dye attenuates bleomycin-induced lung fibrosis by regulating the NF-κB and NLRP3 crosstalk: A novel approach for filling an unmet medical need

Biomedicine & pharmacotherapy, 2022-04, Vol.148, p.112723-112723, Article 112723

2022

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Pimitespib, an HSP90 inhibitor, augments nifuroxazide-induced disruption in the IL-6/STAT3/HIF-1α autocrine loop in rats with bleomycin-challenged lungs: Evolutionary perspective in managing pulmonary fibrosis

Biomedicine & pharmacotherapy, 2022-09, Vol.153, p.113487-113487, Article 113487

2022

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Orexins in apoptosis: a dual regulatory role

Frontiers in cellular neuroscience, 2024-04, Vol.18, p.1336145-1336145

2024

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AKT-AMPKα-mTOR-dependent HIF-1α Activation is a New Therapeutic Target for Cancer Treatment: A Novel Approach to Repositioning the Antidiabetic Drug Sitagliptin for the Management of Hepatocellular Carcinoma

Frontiers in pharmacology, 2022-01, Vol.12, p.720173-720173

2022

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Activation of AMPK/SIRT1/FOXO3a signaling by BMS-477118 (saxagliptin) mitigates chronic colitis in rats: uncovering new anti-inflammatory and antifibrotic roles

Frontiers in pharmacology, 2024-09, Vol.15, p.1456058

2024

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Cardioprotective role of GTS-21 by attenuating the TLR4/NF-κB pathway in streptozotocin-induced diabetic cardiomyopathy in rats

Naunyn-Schmiedeberg's archives of pharmacology, 2021, Vol.394 (1), p.11-31

2021

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BBG enhances OLT1177-induced NLRP3 inflammasome inactivation by targeting P2X7R/NLRP3 and MyD88/NF-κB signaling in DSS-induced colitis in rats

Life sciences (1973), 2021-04, Vol.270, p.119123, Article 119123

2021

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Unveiling citicoline's mechanisms and clinical relevance in the treatment of neuroinflammatory disorders

The FASEB journal, 2024-09, Vol.38 (17), p.e70030-n/a

2024

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Electrocardiographic and histopathological characterizations of diabetic cardiomyopathy in rats

Environmental science and pollution research international, 2022-04, Vol.29 (17), p.25723-25732

2022

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Blunting p38 MAPKα and ERK1/2 activities by empagliflozin enhances the antifibrotic effect of metformin and augments its AMPK-induced NF-κB inactivation in mice intoxicated with carbon tetrachloride

Life sciences (1973), 2021-12, Vol.286, p.120070-120070, Article 120070

2021

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Advances in understanding cisplatin-induced toxicity: Molecular mechanisms and protective strategies

European journal of pharmaceutical sciences, 2024-12, Vol.203, p.106939, Article 106939

2024

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Mechanistic insights into carvedilol's potential protection against doxorubicin-induced cardiotoxicity

European journal of pharmaceutical sciences, 2024-09, Vol.200, p.106849, Article 106849

2024

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Tracking the therapeutic efficacy of a ketone mono ester and β-hydroxybutyrate for ulcerative colitis in rats: New perspectives

Toxicology and applied pharmacology, 2024-05, Vol.486, p.116943-116943, Article 116943

2024

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A novel combination therapy targets sonic hedgehog signaling by the dual inhibition of HMG-CoA reductase and HSP90 in rats with non-alcoholic steatohepatitis

European journal of pharmaceutical sciences, 2024-07, Vol.198, p.106792-106792, Article 106792

2024

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Unlocking the Full Potential of SGLT2 Inhibitors: Expanding Applications beyond Glycemic Control

Role of Ganetespib, an HSP90 Inhibitor, in Cancer Therapy: From Molecular Mechanisms to Clinical Practice

Interference With the AMPKα/mTOR/NLRP3 Signaling and the IL-23/IL-17 Axis Effectively Protects Against the Dextran Sulfate Sodium Intoxication in Rats: A New Paradigm in Empagliflozin and Metformin Reprofiling for the Management of Ulcerative Colitis

Ameliorative Effect of Dabigatran on CFA-Induced Rheumatoid Arthritis via Modulating Kallikrein-Kinin System in Rats

Canagliflozin-loaded chitosan-hyaluronic acid microspheres modulate AMPK/NF-κB/NLRP3 axis: A new paradigm in the rectal therapy of ulcerative colitis

Empagliflozin adjunct with metformin for the inhibition of hepatocellular carcinoma progression: Emerging approach for new application

α7-nAChRs-mediated therapeutic angiogenesis accounts for the advantageous effect of low nicotine doses against myocardial infarction in rats

Innovative challenge for the inhibition of hepatocellular carcinoma progression by combined targeting of HSP90 and STAT3/HIF-1α signaling

Carbocisteine as a Modulator of Nrf2/HO-1 and NFκB Interplay in Rats: New Inspiration for the Revival of an Old Drug for Treating Ulcerative Colitis

Coomassie brilliant blue G-250 dye attenuates bleomycin-induced lung fibrosis by regulating the NF-κB and NLRP3 crosstalk: A novel approach for filling an unmet medical need

Pimitespib, an HSP90 inhibitor, augments nifuroxazide-induced disruption in the IL-6/STAT3/HIF-1α autocrine loop in rats with bleomycin-challenged lungs: Evolutionary perspective in managing pulmonary fibrosis

Orexins in apoptosis: a dual regulatory role

AKT-AMPKα-mTOR-dependent HIF-1α Activation is a New Therapeutic Target for Cancer Treatment: A Novel Approach to Repositioning the Antidiabetic Drug Sitagliptin for the Management of Hepatocellular Carcinoma

Activation of AMPK/SIRT1/FOXO3a signaling by BMS-477118 (saxagliptin) mitigates chronic colitis in rats: uncovering new anti-inflammatory and antifibrotic roles

Cardioprotective role of GTS-21 by attenuating the TLR4/NF-κB pathway in streptozotocin-induced diabetic cardiomyopathy in rats

BBG enhances OLT1177-induced NLRP3 inflammasome inactivation by targeting P2X7R/NLRP3 and MyD88/NF-κB signaling in DSS-induced colitis in rats

Unveiling citicoline's mechanisms and clinical relevance in the treatment of neuroinflammatory disorders

Electrocardiographic and histopathological characterizations of diabetic cardiomyopathy in rats

Ambroxol, a mucolytic agent, boosts HO‐1, suppresses NF‐κB, and decreases the susceptibility of the inflamed rat colon to apoptosis: A new treatment option for treating ulcerative colitis

Blunting p38 MAPKα and ERK1/2 activities by empagliflozin enhances the antifibrotic effect of metformin and augments its AMPK-induced NF-κB inactivation in mice intoxicated with carbon tetrachloride

Advances in understanding cisplatin-induced toxicity: Molecular mechanisms and protective strategies

Mechanistic insights into carvedilol's potential protection against doxorubicin-induced cardiotoxicity

Unlocking vinpocetine's oncostatic potential in early-stage hepatocellular carcinoma: A new approach to oncogenic modulation by a nootropic drug

Tracking the therapeutic efficacy of a ketone mono ester and β-hydroxybutyrate for ulcerative colitis in rats: New perspectives

A novel combination therapy targets sonic hedgehog signaling by the dual inhibition of HMG-CoA reductase and HSP90 in rats with non-alcoholic steatohepatitis

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