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Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)
Journal of medicinal chemistry, 2012-05, Vol.55 (9), p.4101-4113
2012
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Quantification of an Antibody-Conjugated Drug in Fat Plasma by an Affinity Capture LC-MS/MS Method for a Novel Prenyl Transferase-Mediated Site-Specific Antibody-Drug Conjugate
Molecules (Basel, Switzerland), 2020-03, Vol.25 (7), p.1515
2020
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Pharmacokinetic and Metabolism Studies of Monomethyl Auristatin F via Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry
Molecules (Basel, Switzerland), 2019-07, Vol.24 (15), p.2754
2019
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Quantification and Metabolite Identification of Sulfasalazine in Mouse Brain and Plasma Using Quadrupole-Time-of-Flight Mass Spectrometry
Molecules (Basel, Switzerland), 2021-02, Vol.26 (4), p.1179
2021
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Evaluation of In Vivo Prepared Albumin-Drug Conjugate Using Immunoprecipitation Linked LC-MS Assay and Its Application to Mouse Pharmacokinetic Study
Molecules (Basel, Switzerland), 2023-04, Vol.28 (7), p.3223
2023
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Quantitative Analysis of Tozadenant Using Liquid Chromatography-Mass Spectrometric Method in Rat Plasma and Its Human Pharmacokinetics Prediction Using Physiologically Based Pharmacokinetic Modeling
Molecules (Basel, Switzerland), 2019-04, Vol.24 (7), p.1295
2019
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In Vitro, In Silico, and In Vivo Assessments of Pharmacokinetic Properties of ZM241385
Molecules (Basel, Switzerland), 2020-03, Vol.25 (5), p.1106
2020
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Quantitative Analysis of Daporinad (FK866) and Its In Vitro and In Vivo Metabolite Identification Using Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry
Molecules (Basel, Switzerland), 2022-03, Vol.27 (6), p.2011
2022
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Investigation of In Vitro and In Vivo Metabolism of α-Amanitin in Rats Using Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometric Method
Molecules (Basel, Switzerland), 2022-12, Vol.27 (23), p.8612
2022
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Assessment of Pharmacokinetics and Metabolism Profiles of SCH 58261 in Rats Using Liquid Chromatography-Mass Spectrometric Method
Molecules (Basel, Switzerland), 2020-05, Vol.25 (9), p.2209
2020
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Assessments of the In Vitro and In Vivo Linker Stability and Catabolic Fate for the Ortho Hydroxy-Protected Aryl Sulfate Linker by Immuno-Affinity Capture Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometric Assay
Pharmaceutics, 2021-01, Vol.13 (1), p.125
2021
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Profiling and Identification of Omeprazole Metabolites in Mouse Brain and Plasma by Isotope Ratio-Monitoring Liquid Chromatography-Mass Spectrometric Method
Life (Basel, Switzerland), 2020-07, Vol.10 (7), p.115
2020
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Comparison of metabolic soft spot predictions of CYP3A4, CYP2C9 and CYP2D6 substrates using MetaSite and StarDrop
Combinatorial chemistry & high throughput screening, 2011-11, Vol.14 (9), p.811
2011
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Analysis of Vipadenant and Its In Vitro and In Vivo Metabolites via Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometry
Pharmaceutics, 2018-12, Vol.10 (4), p.260
2018
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Qualification and Application of a Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometric Method for the Determination of Adalimumab in Rat Plasma
Pharmaceutics, 2018-05, Vol.10 (2), p.61
2018
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Prediction of pharmacokinetics and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach: A case study of caffeine and ciprofloxacin
The Korean Journal of Physiology & Pharmacology, 2017, 21(1), , pp.107-115
2017
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A single dose mass balance study of the Hedgehog pathway inhibitor vismodegib (GDC-0449) in humans using accelerator mass spectrometry
Drug metabolism and disposition, 2011-08, Vol.39 (8), p.1460
2011
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Effect of Ticagrelor, a Cytochrome P450 3A4 Inhibitor, on the Pharmacokinetics of Tadalafil in Rats
Pharmaceutics, 2019-07, Vol.11 (7), p.354
2019
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Quantification for Antibody-Conjugated Drug in Trastuzumab Emtansine and Application to In Vitro Linker Stability and In Vivo Pharmacokinetic Study in Rat Using an Immuno-Affinity Capture Liquid Chromatography-Mass Spectrometric Method
Applied sciences, 2021-10, Vol.11 (20), p.9437
2021
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A Liquid Chromatography-Quadrupole-Time-of-Flight Mass Spectrometric Assay for the Quantification of Fabry Disease Biomarker Globotriaosylceramide (GB3) in Fabry Model Mouse
Pharmaceutics, 2018-06, Vol.10 (2), p.69
2018
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Application of Pharmacokinetic-Pharmacodynamic Modeling and Simulation for Antibody-Drug Conjugate Development
Pharmaceutical research, 2015-11, Vol.32 (11), p.3508-3525
2015
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Opportunities in low-level radiocarbon microtracing: applications and new technology
Future science OA, 2016-03, Vol.2 (1), p.FSO74-FSO74
2016
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First-in-human study of IM156, a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors
Investigational new drugs, 2022-10, Vol.40 (5), p.1001-1010
2022
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Screening and ADME characterization of ADCs
Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S1-S1
2017
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Liquid chromatography‐high resolution mass spectrometric method for the quantification of monomethyl auristatin E (MMAE) and its preclinical pharmacokinetics
Biomedical chromatography, 2020-08, Vol.34 (8), p.e4855-n/a
2020
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