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Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial

Nature medicine, 2021-10, Vol.27 (10), p.1725-1734

2021

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3′ RNA Elements in Hepatitis C Virus Replication: Kissing Partners and Long Poly(U)

Journal of Virology, 2008-01, Vol.82 (1), p.184-195

2008

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Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C

Proceedings of the National Academy of Sciences - PNAS, 2020-11, Vol.117 (44), p.27598-27607

2020

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ZAP's stress granule localization is correlated with its antiviral activity and induced by virus replication

PLoS pathogens, 2019-05, Vol.15 (5), p.e1007798-e1007798

2019

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Gene Expression Profiling Indicates the Roles of Host Oxidative Stress, Apoptosis, Lipid Metabolism, and Intracellular Transport Genes in the Replication of Hepatitis C Virus

Journal of Virology, 2010-05, Vol.84 (10), p.5404-5414

2010

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The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors

The Journal of biological chemistry, 2015-08, Vol.290 (32), p.19681-19696

2015

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Studying hepatitis C virus: Making the best of a bad virus

Journal of virology, 2007-09, Vol.81 (17), p.8853-8867

2007

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Preclinical Characterization of GSK2336805, a Novel Inhibitor of Hepatitis C Virus Replication That Selects for Resistance in NS5A

Antimicrobial Agents and Chemotherapy, 2014-01, Vol.58 (1), p.38-47

2014

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A cis-Acting Replication Element in the Sequence Encoding the NS5B RNA-Dependent RNA Polymerase Is Required for Hepatitis C Virus RNA Replication

Journal of Virology, 2004-02, Vol.78 (3), p.1352-1366

2004

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In Vitro Characterization of GSK2485852, a Novel Hepatitis C Virus Polymerase Inhibitor

Antimicrobial Agents and Chemotherapy, 2013-11, Vol.57 (11), p.5216-5224

2013

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De Novo Synthesis of Negative-Strand RNA by Dengue Virus RNA-Dependent RNA Polymerase In Vitro: Nucleotide, Primer, and Template Parameters

Journal of Virology, 2003-08, Vol.77 (16), p.8831-8842

2003

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The Serine Protease and RNA-Stimulated Nucleoside Triphosphatase and RNA Helicase Functional Domains of Dengue Virus Type 2 NS3 Converge within a Region of 20 Amino Acids

Journal of Virology, 1999-04, Vol.73 (4), p.3108-3116

1999

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Reply to: “Bepirovirsen/GSK3389404: Antisense or TLR9 agonists?”

Journal of hepatology, 2023-03, Vol.78 (3), p.e108-e110

2023

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Multi-Modal Imaging with a Toolbox of Influenza AReporter Viruses

Viruses, 2015-10, Vol.7 (10), p.5319-5327

2015

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End game: Getting the most out of microRNAs

Proceedings of the National Academy of Sciences - PNAS, 2011-02, Vol.108 (8), p.3101-3102

2011

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SAT-196 - Cell-mediated immunity analysis to assess the characteristics of immune response to bepirovirsen: Examples from the B-Clear study

Journal of hepatology, 2023-06, Vol.78, p.S1167-S1169

2023

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Cell-mediated immunity analysis to assess the characteristics of immune response to bepirovirsen: Examples from the B-Clear study

Journal of hepatology, 2023-06, Vol.78, p.S1167-S1169

2023

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SAT-390 Nonclinical phenotypic evaluation of clinically identified baseline and treatment-emergent hepatitis B Virus variants that contain single nucleotide polymorphisms in the bepirovirsen binding site

Journal of hepatology, 2024-06, Vol.80, p.S745-S745

2024

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Bepirovirsen, antisense oligonucleotide (ASO) against hepatitis B virus (HBV), harbors intrinsic immunostimulatory activity via Toll-like receptor 8 (TLR8) preclinically, correlating with clinical efficacy from the Phase 2a study

Journal of hepatology, 2022-07, Vol.77, p.S873-S874

2022

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Combination treatment of a PAPD5/7 inhibitor with an antisense oligonucleotide bepirovirsen with concurrent dosing shows additive HBsAg decreases in the AAV-HBV mouse model

Journal of hepatology, 2022-07, Vol.77, p.S880

2022

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SAT-176 - Analysis of HBV genotype association to bepirovirsen treatment response in patients with chronic HBV infection (Phase 2b B-Clear study)

Journal of hepatology, 2023-06, Vol.78, p.S1154-S1155

2023

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SAT-187 - Frequency of bepirovirsen binding site nucleotide polymorphisms at baseline and impact on end of treatment response to bepirovirsen (Phase 2b B-Clear study)

Journal of hepatology, 2023-06, Vol.78, p.S1162-S1162

2023

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Frequency of bepirovirsen binding site nucleotide polymorphisms at baseline and impact on end of treatment response to bepirovirsen (Phase 2b B-Clear study)

Journal of hepatology, 2023-06, Vol.78, p.S1162

2023

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Analysis of HBV genotype association to bepirovirsen treatment response in patients with chronic HBV infection (Phase 2b B-Clear study)

Journal of hepatology, 2023-06, Vol.78, p.S1154-S1155

2023

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A primary human hepatocyte system to evaluate antisense oligonucleotide activity against clinically identified hepatitis B virus variants that contain mismatches in the bepirovirsen binding site

Journal of hepatology, 2023-06, Vol.78, p.S1039-S1040

2023

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Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial

3′ RNA Elements in Hepatitis C Virus Replication: Kissing Partners and Long Poly(U)

Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C

ZAP's stress granule localization is correlated with its antiviral activity and induced by virus replication

Gene Expression Profiling Indicates the Roles of Host Oxidative Stress, Apoptosis, Lipid Metabolism, and Intracellular Transport Genes in the Replication of Hepatitis C Virus

The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors

Studying hepatitis C virus: Making the best of a bad virus

Preclinical Characterization of GSK2336805, a Novel Inhibitor of Hepatitis C Virus Replication That Selects for Resistance in NS5A

A cis-Acting Replication Element in the Sequence Encoding the NS5B RNA-Dependent RNA Polymerase Is Required for Hepatitis C Virus RNA Replication

In Vitro Characterization of GSK2485852, a Novel Hepatitis C Virus Polymerase Inhibitor

De Novo Synthesis of Negative-Strand RNA by Dengue Virus RNA-Dependent RNA Polymerase In Vitro: Nucleotide, Primer, and Template Parameters

The Serine Protease and RNA-Stimulated Nucleoside Triphosphatase and RNA Helicase Functional Domains of Dengue Virus Type 2 NS3 Converge within a Region of 20 Amino Acids

Reply to: “Bepirovirsen/GSK3389404: Antisense or TLR9 agonists?”

Multi-Modal Imaging with a Toolbox of Influenza AReporter Viruses

End game: Getting the most out of microRNAs

SAT-196 - Cell-mediated immunity analysis to assess the characteristics of immune response to bepirovirsen: Examples from the B-Clear study

Cell-mediated immunity analysis to assess the characteristics of immune response to bepirovirsen: Examples from the B-Clear study

SAT-390 Nonclinical phenotypic evaluation of clinically identified baseline and treatment-emergent hepatitis B Virus variants that contain single nucleotide polymorphisms in the bepirovirsen binding site

Bepirovirsen, antisense oligonucleotide (ASO) against hepatitis B virus (HBV), harbors intrinsic immunostimulatory activity via Toll-like receptor 8 (TLR8) preclinically, correlating with clinical efficacy from the Phase 2a study

Combination treatment of a PAPD5/7 inhibitor with an antisense oligonucleotide bepirovirsen with concurrent dosing shows additive HBsAg decreases in the AAV-HBV mouse model

SAT-176 - Analysis of HBV genotype association to bepirovirsen treatment response in patients with chronic HBV infection (Phase 2b B-Clear study)

SAT-187 - Frequency of bepirovirsen binding site nucleotide polymorphisms at baseline and impact on end of treatment response to bepirovirsen (Phase 2b B-Clear study)

Frequency of bepirovirsen binding site nucleotide polymorphisms at baseline and impact on end of treatment response to bepirovirsen (Phase 2b B-Clear study)

Analysis of HBV genotype association to bepirovirsen treatment response in patients with chronic HBV infection (Phase 2b B-Clear study)

A primary human hepatocyte system to evaluate antisense oligonucleotide activity against clinically identified hepatitis B virus variants that contain mismatches in the bepirovirsen binding site

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