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Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy

Journal of hematology and oncology, 2020-05, Vol.13 (1), p.50-14, Article 50

2020

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Structure, function and inhibition of critical protein-protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins

Journal of hematology and oncology, 2021-04, Vol.14 (1), p.56-33, Article 56

2021

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Regioselective Radical Aminofluorination of Styrenes

Angewandte Chemie International Edition, 2014-10, Vol.53 (41), p.11079-11083

International ed. in English, 2014

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Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives

Journal of hematology and oncology, 2016-06, Vol.9 (1), p.49-49, Article 49

2016

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DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy

PloS one, 2014-05, Vol.9 (5), p.e98270-e98270

2014

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A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L

Journal of medicinal chemistry, 2013-11, Vol.56 (22), p.8972

2013

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A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth

Journal of hematology and oncology, 2022-04, Vol.15 (1), p.41-41, Article 41

2022

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3‑(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1

Journal of medicinal chemistry, 2016-01, Vol.59 (1), p.253-263

2016

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An epigenomic approach to therapy for tamoxifen-resistant breast cancer

Cell research, 2014-07, Vol.24 (7), p.809-819

2014

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Thermodynamic investigation of DNA-binding affinity of wild-type and mutant transcription factor RUNX1

PloS one, 2019-05, Vol.14 (5), p.e0216203-e0216203

2019

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Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review

European journal of medicinal chemistry, 2023-11, Vol.260, p.115772, Article 115772

2023

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Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2‑Thiohydantoin Compounds

Journal of medicinal chemistry, 2015-09, Vol.58 (17), p.6899-6908

2015

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Characterization of sea buckthorn polysaccharides and the analysis of its regulatory effect on the gut microbiota imbalance induced by cefixime in mice

Journal of functional foods, 2023-05, Vol.104, p.105511, Article 105511

2023

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DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia

Blood, 2016-08, Vol.128 (7), p.971-981

2016

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Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies

Journal of the American Chemical Society, 2011-10, Vol.133 (42), p.16746-16749

2011

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Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence

Science (American Association for the Advancement of Science), 2008-03, Vol.319 (5868), p.1391-1394

2008

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Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma

Oncotarget, 2016-05, Vol.7 (18), p.26307-26330

2016

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Targeting SARS-CoV-2 nonstructural protein 3: Function, structure, inhibition, and perspective in drug discovery

Drug discovery today, 2024-01, Vol.29 (1), p.103832-103832, Article 103832

2024

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Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia

Journal of hematology and oncology, 2016-03, Vol.9 (1), p.24-13, Article 24

2016

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Perspective for Drug Discovery Targeting SARS Coronavirus Methyltransferases: Function, Structure and Inhibition

Journal of medicinal chemistry, 2024-10

2024

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Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer

Oncotarget, 2014-11, Vol.5 (21), p.10665-10677

2014

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Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii

The Journal of experimental medicine, 2011-07, Vol.208 (7), p.1547-1559

2011

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Synthesis and Structure–Activity Relationship Investigation of Adenosine-Containing Inhibitors of Histone Methyltransferase DOT1L

Journal of medicinal chemistry, 2012-09, Vol.55 (18), p.8066-8074

2012

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Structure activity relationship and modeling studies of inhibitors of lysine specific demethylase 1

PloS one, 2017-02, Vol.12 (2), p.e0170301-e0170301

2017

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Verifiable image revision from chameleon hashes

Cybersecurity (Singapore), 2021-10, Vol.4 (1), p.1-13, Article 34

2021

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Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy

Structure, function and inhibition of critical protein-protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins

Regioselective Radical Aminofluorination of Styrenes

Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives

DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy

A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L

A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth

3‑(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1

An epigenomic approach to therapy for tamoxifen-resistant breast cancer

Thermodynamic investigation of DNA-binding affinity of wild-type and mutant transcription factor RUNX1

Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review

Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2‑Thiohydantoin Compounds

Characterization of sea buckthorn polysaccharides and the analysis of its regulatory effect on the gut microbiota imbalance induced by cefixime in mice

DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia

Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies

Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence

Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma

Targeting SARS-CoV-2 nonstructural protein 3: Function, structure, inhibition, and perspective in drug discovery

Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia

Perspective for Drug Discovery Targeting SARS Coronavirus Methyltransferases: Function, Structure and Inhibition

Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer

Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii

Synthesis and Structure–Activity Relationship Investigation of Adenosine-Containing Inhibitors of Histone Methyltransferase DOT1L

Structure activity relationship and modeling studies of inhibitors of lysine specific demethylase 1

Verifiable image revision from chameleon hashes

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