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Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers

Drug metabolism and pharmacokinetics, 2022-06, Vol.44, p.100454-100454, Article 100454

2022

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In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits

Nature communications, 2020-01, Vol.11 (1), p.45-13, Article 45

2020

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o-Toluidine metabolism and effects in the urinary bladder of humanized-liver mice

Toxicology (Amsterdam), 2023-04, Vol.488, p.153483-153483, Article 153483

2023

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Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation

Drug metabolism and pharmacokinetics, 2024-06, Vol.56, p.101007, Article 101007

2024

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Observation of second harmonic electron cyclotron resonance heating and current-drive transition during non-inductive plasma start-up experiment in QUEST

Plasma physics and controlled fusion, 2021-10, Vol.63 (10), p.105002

2021

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Highly efficient induction of primate iPS cells by combining RNA transfection and chemical compounds

Genes to cells : devoted to molecular & cellular mechanisms, 2019-07, Vol.24 (7), p.473-484

2019

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Establishment of novel common marmoset embryonic stem cell lines under various conditions

Stem cell research, 2021-05, Vol.53, p.102252-102252, Article 102252

2021

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Novel biomarker for detecting human-specific hepatocyte injury in humanized liver mouse model

Drug metabolism and pharmacokinetics, 2018-01, Vol.33 (1), p.S25-S26

2018

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Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data

Drug metabolism and pharmacokinetics, 2020-08, Vol.35 (4), p.389-396

2020

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Spectroscopic Measurement of Hydrogen Atom Density in a Plasma Produced with 28 GHz ECH in QUEST

Atoms, 2020-09, Vol.8 (3), p.44

2020

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Human Aldehyde Oxidase 1-mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes

Drug metabolism and disposition, 2020-07, Vol.48 (7), p.580-586

2020

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Spectroscopic Measurements of Impurity Ion Toroidal and Poloidal Flow Velocities and Their Dependence on Vertical Magnetic Field in QUEST Toroidal ECR Plasmas

Plasma and Fusion Research, 2018/07/10, Vol.13, pp.3402087-3402087

2018

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Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css–MRTpo method and chimeric mice with humanised livers

Xenobiotica, 2023-09, Vol.53 (8-9), p.523-535

2023

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Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes

Xenobiotica, 2021-05, Vol.51 (5), p.582-589

2021

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Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes

Drug metabolism and pharmacokinetics, 2021-12, Vol.41, p.100419-100419, Article 100419

2021

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UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers

Xenobiotica, 2021-10, Vol.51 (10), p.1146-1154

2021

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SGX523 causes renal toxicity through aldehyde oxidase-mediated less-soluble metabolite formation in chimeric mice with humanized livers

Toxicology letters, 2023-10, Vol.388, p.48-55

2023

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The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers

Drug metabolism and disposition, 2023-04, Vol.51 (4), p.480-491

2023

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Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes

Xenobiotica, 2020-06, Vol.50 (6), p.733-740

2020

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Comprehensive gene profiling of the metabolic landscape of humanized livers in mice

Journal of hepatology, 2024-04, Vol.80 (4), p.622-633

2024

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Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanised livers

Xenobiotica, 2019-06, Vol.49 (6), p.678-687

2019

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HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes

Biochemical and biophysical research communications, 2023-06, Vol.663, p.132-141

2023

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Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes

Xenobiotica, 2022-03, Vol.52 (3), p.229-239

2022

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P39 - Metabolism of desloratadine in TK-NOG chimeric mice with humanized livers

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S33-S33

2020

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P119 - Drug-metabolizing activity and cytochromes P450 induction in human hepatocytes from TK-NOG chimeric mice with humanized livers

Drug metabolism and pharmacokinetics, 2020, Vol.35 (1), p.S58-S59

2020

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Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers

In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits

o-Toluidine metabolism and effects in the urinary bladder of humanized-liver mice

Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation

Observation of second harmonic electron cyclotron resonance heating and current-drive transition during non-inductive plasma start-up experiment in QUEST

Highly efficient induction of primate iPS cells by combining RNA transfection and chemical compounds

Establishment of novel common marmoset embryonic stem cell lines under various conditions

Novel biomarker for detecting human-specific hepatocyte injury in humanized liver mouse model

Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data

Spectroscopic Measurement of Hydrogen Atom Density in a Plasma Produced with 28 GHz ECH in QUEST

Human Aldehyde Oxidase 1-mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes

Spectroscopic Measurements of Impurity Ion Toroidal and Poloidal Flow Velocities and Their Dependence on Vertical Magnetic Field in QUEST Toroidal ECR Plasmas

Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css–MRTpo method and chimeric mice with humanised livers

Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes

Oxidative metabolism and pharmacokinetics of the EGFR inhibitor BIBX1382 in chimeric NOG-TKm30 mice transplanted with human hepatocytes

UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers

SGX523 causes renal toxicity through aldehyde oxidase-mediated less-soluble metabolite formation in chimeric mice with humanized livers

The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers

Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes

Comprehensive gene profiling of the metabolic landscape of humanized livers in mice

Expression and inducibility of cytochrome P450s in human hepatocytes isolated from chimeric mice with humanised livers

HepaSH cells: Experimental human hepatocytes with lesser inter-individual variation and more sustainable availability than primary human hepatocytes

Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes

P39 - Metabolism of desloratadine in TK-NOG chimeric mice with humanized livers

P119 - Drug-metabolizing activity and cytochromes P450 induction in human hepatocytes from TK-NOG chimeric mice with humanized livers

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