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Structural analyses of the malaria parasite aminoacyl‐tRNA synthetases provide new avenues for antimalarial drug discovery

Protein science, 2021-09, Vol.30 (9), p.1793-1803

2021

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Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines

Nature communications, 2021-01, Vol.12 (1), p.343-10, Article 343

2021

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Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum

Drug discovery today, 2018-06, Vol.23 (6), p.1233-1240

2018

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Inhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetases

Antimicrobial agents and chemotherapy, 2015-04, Vol.59 (4), p.1856-1867

2015

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Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis

Structure (London), 2015-05, Vol.23 (5), p.819-829

2015

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Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein

Acta crystallographica. Section D, Biological crystallography., 2020-02, Vol.76 (2), p.135-146

2020

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Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis

PLoS neglected tropical diseases, 2016-11, Vol.10 (11), p.e0005084-e0005084

2016

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A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

The Journal of experimental medicine, 2013-09, Vol.210 (10), p.2071-2086

2013

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Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5664-5678

2018

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Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis

Structure (London), 2017-10, Vol.25 (10), p.1495-1505.e6

2017

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Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development

PLoS pathogens, 2022-03, Vol.18 (3), p.e1010363-e1010363

2022

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Conformational heterogeneity in apo and drug‐bound structures of Toxoplasma gondii prolyl‐tRNA synthetase

Acta crystallographica. Section F, Structural biology communications, 2019-11, Vol.75 (11), p.714-724

2019

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Structural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporin

Journal of structural and functional genomics, 2014-06, Vol.15 (2), p.63-71

2014

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ATP mimetics targeting prolyl-tRNA synthetases as a new avenue for antimalarial drug development

iScience, 2024-07, Vol.27 (7), p.110049, Article 110049

2024

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Structure–Function Analysis of Liver Flavin Monooxygenase 3 that Drives Trimethylaminuria in Humans

National Academy of Sciences, India. Proceedings. Section B. Biological Sciences, 2018-12, Vol.88 (4), p.1681-1690

2018

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Structural and Biochemical Characterization of Apicomplexan Inorganic Pyrophosphatases

Scientific reports, 2017-07, Vol.7 (1), p.5255-14, Article 5255

2017

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An appended domain results in an unusual architecture for malaria parasite tryptophanyl-tRNA synthetase

PloS one, 2013-06, Vol.8 (6), p.e66224-e66224

2013

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Ligand-bound Structures Provide Atomic Snapshots for the Catalytic Mechanism of d-Amino Acid Deacylase

The Journal of biological chemistry, 2010-02, Vol.285 (8), p.5917-5930

2010

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Structural delineation of histone post-translation modifications in histone-nucleosome assembly protein complex

Journal of structural biology, 2012-10, Vol.180 (1), p.1-9

2012

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Engagement Rules That Underpin DBL-DARC Interactions for Ingress of Plasmodium knowlesi and Plasmodium vivax Into Human Erythrocytes

Frontiers in molecular biosciences, 2018-08, Vol.5, p.78-78

2018

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Structure, localization and histone binding properties of nuclear-associated nucleosome assembly protein from Plasmodium falciparum

Malaria journal, 2010-04, Vol.9 (1), p.90-90, Article 90

2010

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Structural characterization of glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum

Molecular and biochemical parasitology, 2023-02, Vol.253, p.111530-111530, Article 111530

2023

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Dimerization of Arginyl-tRNA Synthetase by Free Heme Drives Its Inactivation in Plasmodium falciparum

Structure (London), 2016-09, Vol.24 (9), p.1476-1487

2016

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Systematic analysis of proteomes with emphasis on insertions in malaria parasite Plasmodium falciparum

Protein and peptide letters, 2013-10, Vol.20 (10), p.1088

2013

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Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes

International journal of biological macromolecules, 2018-12, Vol.120 (Pt B), p.1379-1386

2018

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Structural analyses of the malaria parasite aminoacyl‐tRNA synthetases provide new avenues for antimalarial drug discovery

Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines

Drug targeting of one or more aminoacyl-tRNA synthetase in the malaria parasite Plasmodium falciparum

Inhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetases

Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis

Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein

Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis

A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite

Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis

Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development

Conformational heterogeneity in apo and drug‐bound structures of Toxoplasma gondii prolyl‐tRNA synthetase

Structural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporin

ATP mimetics targeting prolyl-tRNA synthetases as a new avenue for antimalarial drug development

Structure–Function Analysis of Liver Flavin Monooxygenase 3 that Drives Trimethylaminuria in Humans

Structural and Biochemical Characterization of Apicomplexan Inorganic Pyrophosphatases

An appended domain results in an unusual architecture for malaria parasite tryptophanyl-tRNA synthetase

Ligand-bound Structures Provide Atomic Snapshots for the Catalytic Mechanism of d-Amino Acid Deacylase

Structural delineation of histone post-translation modifications in histone-nucleosome assembly protein complex

Engagement Rules That Underpin DBL-DARC Interactions for Ingress of Plasmodium knowlesi and Plasmodium vivax Into Human Erythrocytes

Structure, localization and histone binding properties of nuclear-associated nucleosome assembly protein from Plasmodium falciparum

Structural characterization of glutamyl-tRNA synthetase (GluRS) from Plasmodium falciparum

Dimerization of Arginyl-tRNA Synthetase by Free Heme Drives Its Inactivation in Plasmodium falciparum

Systematic analysis of proteomes with emphasis on insertions in malaria parasite Plasmodium falciparum

Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes

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