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Filamins in Mechanosensing and Signaling

Annual review of biophysics, 2012-06, Vol.41 (1), p.227-246

2012

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Dynamic force sensing of filamin revealed in single-molecule experiments

Proceedings of the National Academy of Sciences - PNAS, 2012-11, Vol.109 (48), p.19679-19684

2012

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Small-angle X-ray scattering reveals compact domain-domain interactions in the N-terminal region of filamin C

PloS one, 2014-09, Vol.9 (9), p.e107457-e107457

2014

Volltextzugriff (PDF)

Phosphorylated immunoreceptor tyrosine-based activation motifs and integrin cytoplasmic domains activate spleen tyrosine kinase via distinct mechanisms

The Journal of biological chemistry, 2018-03, Vol.293 (13), p.4591-4602

2018

Volltextzugriff (PDF)

Evidence for the mechanosensor function of filamin in tissue development

Scientific reports, 2016-09, Vol.6 (1), p.32798-32798, Article 32798

2016

Volltextzugriff (PDF)

The Regulation Mechanism for the Auto-Inhibition of Binding of Human Filamin A to Integrin

Journal of molecular biology, 2009-10, Vol.393 (3), p.644-657

2009

Volltextzugriff (PDF)

Novel functions for integrin-associated proteins revealed by analysis of myofibril attachment in Drosophila

eLife, 2018-07, Vol.7

2018

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Binding properties and stability of the Ras-association domain of Rap1-GTP interacting adapter molecule (RIAM)

PloS one, 2012-04, Vol.7 (4), p.e31955-e31955

2012

Volltextzugriff (PDF)

Model of a Six Immunoglobulin-Like Domain Fragment of Filamin A (16–21) Built Using Residual Dipolar Couplings

Journal of the American Chemical Society, 2012-04, Vol.134 (15), p.6660-6672

2012

Volltextzugriff (PDF)

Negative regulators of integrin activity

Journal of cell science, 2012-07, Vol.125 (Pt 14), p.3271-3280

2012

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Flexible Structure of Peptide-Bound Filamin A Mechanosensor Domain Pair 20-21

PloS one, 2015-08, Vol.10 (8), p.e0136969-e0136969

2015

Volltextzugriff (PDF)

The structure of the GPIb–filamin A complex

Blood, 2006-03, Vol.107 (5), p.1925-1932

2006

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Skeletal Dysplasia Mutations Effect on Human Filamins' Structure and Mechanosensing

Scientific reports, 2017-06, Vol.7 (1), p.4218-14, Article 4218

2017

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Structure of three tandem filamin domains reveals auto-inhibition of ligand binding

The EMBO journal, 2007-09, Vol.26 (17), p.3993-4004

2007

Volltextzugriff (PDF)

The spectrin repeat: a structural platform for cytoskeletal protein assemblies

FEBS Letters, 2002-02, Vol.513 (1), p.119-123

2002

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Assembly of a Filamin Four-domain Fragment and the Influence of Splicing Variant-1 on the Structure

The Journal of biological chemistry, 2011-07, Vol.286 (30), p.26921-26930

2011

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Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations

PloS one, 2009-03, Vol.4 (3), p.e4928

2009

Volltextzugriff (PDF)

Filopodia-like Actin Cables Position Nuclei in Association with Perinuclear Actin in Drosophila Nurse Cells

Developmental cell, 2013-09, Vol.26 (6), p.604-615

2013

Volltextzugriff (PDF)

Structural Basis for Vertebrate Filamin Dimerization

Structure (London), 2005, Vol.13 (1), p.111-119

2005

Volltextzugriff (PDF)

Crystal Structure of Human Filamin C Domain 23 and Small Angle Scattering Model for Filamin C 23–24 Dimer

Journal of molecular biology, 2007-05, Vol.368 (4), p.1011-1023

2007

Volltextzugriff (PDF)

Structural Basis of the Migfilin-Filamin Interaction and Competition with Integrin β Tails

The Journal of biological chemistry, 2008-12, Vol.283 (50), p.35154-35163

2008

Volltextzugriff (PDF)

Novel structural insights into F-actin-binding and novel functions of calponin homology domains

Current opinion in structural biology, 2008-12, Vol.18 (6), p.702-708

2008

Volltextzugriff (PDF)

The C-terminal rod 2 fragment of filamin A forms a compact structure that can be extended

Biochemical journal, 2012-09, Vol.446 (2), p.261-269

2012

Volltextzugriff (PDF)

A Novel Structural Unit in the N-terminal Region of Filamins

The Journal of biological chemistry, 2014-03, Vol.289 (12), p.8588-8598

2014

Volltextzugriff (PDF)

β2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding

Blood, 2008-09, Vol.112 (5), p.1853-1862

2008

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Filamins in Mechanosensing and Signaling

Dynamic force sensing of filamin revealed in single-molecule experiments

Small-angle X-ray scattering reveals compact domain-domain interactions in the N-terminal region of filamin C

Phosphorylated immunoreceptor tyrosine-based activation motifs and integrin cytoplasmic domains activate spleen tyrosine kinase via distinct mechanisms

Evidence for the mechanosensor function of filamin in tissue development

The Regulation Mechanism for the Auto-Inhibition of Binding of Human Filamin A to Integrin

Novel functions for integrin-associated proteins revealed by analysis of myofibril attachment in Drosophila

Binding properties and stability of the Ras-association domain of Rap1-GTP interacting adapter molecule (RIAM)

Model of a Six Immunoglobulin-Like Domain Fragment of Filamin A (16–21) Built Using Residual Dipolar Couplings

Negative regulators of integrin activity

Flexible Structure of Peptide-Bound Filamin A Mechanosensor Domain Pair 20-21

The structure of the GPIb–filamin A complex

Skeletal Dysplasia Mutations Effect on Human Filamins' Structure and Mechanosensing

Structure of three tandem filamin domains reveals auto-inhibition of ligand binding

The spectrin repeat: a structural platform for cytoskeletal protein assemblies

Assembly of a Filamin Four-domain Fragment and the Influence of Splicing Variant-1 on the Structure

Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations

Filopodia-like Actin Cables Position Nuclei in Association with Perinuclear Actin in Drosophila Nurse Cells

Structural Basis for Vertebrate Filamin Dimerization

Crystal Structure of Human Filamin C Domain 23 and Small Angle Scattering Model for Filamin C 23–24 Dimer

Structural Basis of the Migfilin-Filamin Interaction and Competition with Integrin β Tails

Novel structural insights into F-actin-binding and novel functions of calponin homology domains

The C-terminal rod 2 fragment of filamin A forms a compact structure that can be extended

A Novel Structural Unit in the N-terminal Region of Filamins

β2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding

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