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Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis

Molecular cancer, 2010-05, Vol.9 (1), p.122-122, Article 122

2010

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Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

Cancer research (Chicago, Ill.), 2011-03, Vol.71 (5), p.1849-1857

2011

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TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma

Cancer cell, 2010-12, Vol.18 (6), p.655-668

2010

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Smad7 Regulates the Adult Neural Stem/Progenitor Cell Pool in a Transforming Growth Factor β- and Bone Morphogenetic Protein-Independent Manner

Molecular and Cellular Biology, 2010-07, Vol.30 (14), p.3685-3694

2010

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Development of TGF-β signalling inhibitors for cancer therapy

Nature reviews. Drug discovery, 2004-12, Vol.3 (12), p.1011-1022

2004

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Epithelial/mesenchymal interactions and branching morphogenesis of the lung

Current opinion in genetics & development, 1998-08, Vol.8 (4), p.481-486

1998

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Defining a therapeutic window for the novel TGF‐β inhibitor LY2157299 monohydrate based on a pharmacokinetic/pharmacodynamic model

British journal of clinical pharmacology, 2014-05, Vol.77 (5), p.796-807

2014

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Reduced SMAD7 Leads to Overactivation of TGF-β Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-β Receptor I Kinase

Cancer research (Chicago, Ill.), 2011-02, Vol.71 (3), p.955-963

2011

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Developing and applying a gene functional association network for anti-angiogenic kinase inhibitor activity assessment in an angiogenesis co-culture model

BMC genomics, 2008-06, Vol.9 (1), p.264-264, Article 264

2008

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Outgrowth of Drug-Resistant Carcinomas Expressing Markers of Tumor Aggression after Long-term TβRI/II Kinase Inhibition with LY2109761

Cancer research (Chicago, Ill.), 2011-03, Vol.71 (6), p.2339-2349

2011

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Cancer-Associated Transforming Growth Factor β Type II Receptor Gene Mutant Causes Activation of Bone Morphogenic Protein-Smads and Invasive Phenotype

Cancer research (Chicago, Ill.), 2008-03, Vol.68 (6), p.1656-1666

2008

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Effect of transforming growth factor beta (TGF-β) receptor I kinase inhibitor on prostate cancer bone growth

Bone (New York, N.Y.), 2012-03, Vol.50 (3), p.695-703

2012

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Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development

Development (Cambridge), 1999-09, Vol.126 (18), p.4005-4015

1999

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Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain

Journal of medicinal chemistry, 2003-09, Vol.46 (19), p.3953-3956

2003

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Optimization of a Dihydropyrrolopyrazole Series of Transforming Growth Factor-β Type I Receptor Kinase Domain Inhibitors: Discovery of an Orally Bioavailable Transforming Growth Factor-β Receptor Type I Inhibitor as Antitumor Agent

Journal of medicinal chemistry, 2008-04, Vol.51 (7), p.2302-2306

2008

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Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (13), p.3581-3584

2004

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Kinetic Characterization of Novel Pyrazole TGF-β Receptor I Kinase Inhibitors and Their Blockade of the Epithelial−Mesenchymal Transition

Biochemistry (Easton), 2005-02, Vol.44 (7), p.2293-2304

2005

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Smad4-dependent Regulation of Urokinase Plasminogen Activator Secretion and RNA Stability Associated with Invasiveness by Autocrine and Paracrine Transforming Growth Factor-β

The Journal of biological chemistry, 2006-11, Vol.281 (45), p.33971-33981

2006

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Analysis and variability of TGFβ measurements in cancer patients with skeletal metastases

Biologics, 2008-01, Vol.2 (3), p.563-569

Lahn, Michael

2008

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Characterization and development of a peptide substrate-based phosphate transfer assay for the human vascular endothelial growth factor receptor-2 tyrosine kinase

Analytical biochemistry, 2007-01, Vol.360 (2), p.196-206

2007

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TGF-β signalling-related markers in cancer patients with bone metastasis

Biomarkers, 2008-03, Vol.13 (2), p.217-236

2008

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Dihydropyrrolopyrazole Transforming Growth Factor-β Type I Receptor Kinase Domain Inhibitors: A Novel Benzimidazole Series with Selectivity versus Transforming Growth Factor-β Type II Receptor Kinase and Mixed Lineage Kinase-7

Journal of medicinal chemistry, 2006-03, Vol.49 (6), p.2138-2142

2006

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Analysis of Pathway Activity in Primary Tumors and NCI60 Cell Lines Using Gene Expression Profiling Data

Genomics, proteomics & bioinformatics, 2007, Vol.5 (1), p.15-24

2007

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Mammalian Dwarfins are Phosphorylated in Response to Transforming Growth Factor β and are Implicated in Control of Cell Growth

Proceedings of the National Academy of Sciences - PNAS, 1996-08, Vol.93 (17), p.8940-8944

1996

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Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis

Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma

Smad7 Regulates the Adult Neural Stem/Progenitor Cell Pool in a Transforming Growth Factor β- and Bone Morphogenetic Protein-Independent Manner

Development of TGF-β signalling inhibitors for cancer therapy

Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor

Epithelial/mesenchymal interactions and branching morphogenesis of the lung

Defining a therapeutic window for the novel TGF‐β inhibitor LY2157299 monohydrate based on a pharmacokinetic/pharmacodynamic model

Reduced SMAD7 Leads to Overactivation of TGF-β Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-β Receptor I Kinase

Developing and applying a gene functional association network for anti-angiogenic kinase inhibitor activity assessment in an angiogenesis co-culture model

Outgrowth of Drug-Resistant Carcinomas Expressing Markers of Tumor Aggression after Long-term TβRI/II Kinase Inhibition with LY2109761

Cancer-Associated Transforming Growth Factor β Type II Receptor Gene Mutant Causes Activation of Bone Morphogenic Protein-Smads and Invasive Phenotype

Effect of transforming growth factor beta (TGF-β) receptor I kinase inhibitor on prostate cancer bone growth

Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development

Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain

Optimization of a Dihydropyrrolopyrazole Series of Transforming Growth Factor-β Type I Receptor Kinase Domain Inhibitors: Discovery of an Orally Bioavailable Transforming Growth Factor-β Receptor Type I Inhibitor as Antitumor Agent

Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain

Kinetic Characterization of Novel Pyrazole TGF-β Receptor I Kinase Inhibitors and Their Blockade of the Epithelial−Mesenchymal Transition

Smad4-dependent Regulation of Urokinase Plasminogen Activator Secretion and RNA Stability Associated with Invasiveness by Autocrine and Paracrine Transforming Growth Factor-β

Analysis and variability of TGFβ measurements in cancer patients with skeletal metastases

Characterization and development of a peptide substrate-based phosphate transfer assay for the human vascular endothelial growth factor receptor-2 tyrosine kinase

TGF-β signalling-related markers in cancer patients with bone metastasis

Dihydropyrrolopyrazole Transforming Growth Factor-β Type I Receptor Kinase Domain Inhibitors: A Novel Benzimidazole Series with Selectivity versus Transforming Growth Factor-β Type II Receptor Kinase and Mixed Lineage Kinase-7

Analysis of Pathway Activity in Primary Tumors and NCI60 Cell Lines Using Gene Expression Profiling Data

Mammalian Dwarfins are Phosphorylated in Response to Transforming Growth Factor β and are Implicated in Control of Cell Growth

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