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Mechanisms of bile acid mediated inflammation in the liver

Molecular aspects of medicine, 2017-08, Vol.56, p.45-53

2017

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Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response

JCI insight, 2017-03, Vol.2 (5), p.e90780-e90780

2017

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Cenicriviroc, a cytokine receptor antagonist, potentiates all‐trans retinoic acid in reducing liver injury in cholestatic rodents

Liver international, 2018-06, Vol.38 (6), p.1128-1138

2018

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Bile Infarcts: New Insights Into the Pathogenesis of Obstructive Cholestasis

Hepatology (Baltimore, Md.), 2019-02, Vol.69 (2), p.473-475

2019

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Cytoprotective Effect of Antioxidant Pentapeptides from the Protein Hydrolysate of Swim Bladders of Miiuy Croaker (Miichthys miiuy) against H2O2-Mediated Human Umbilical Vein Endothelial Cell (HUVEC) Injury

International journal of molecular sciences, 2019-11, Vol.20 (21), p.5425

2019

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A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis

Cell reports (Cambridge), 2020-02, Vol.30 (5), p.1310-1318.e5

2020

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Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct–ligated rats and human hepatic cells

Hepatology (Baltimore, Md.), 2011-02, Vol.53 (2), p.548-557

2011

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A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis

EMBO molecular medicine, 2021-11, Vol.13 (11), p.e14563-n/a

2021

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Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis

Gastroenterology (New York, N.Y. 1943), 2018-11, Vol.155 (5), p.1578-1592.e16

2018

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Purification of antioxidant peptides of Moringa oleifera seeds and their protective effects on H2O2 oxidative damaged Chang liver cells

Journal of functional foods, 2020-01, Vol.64, p.103698, Article 103698

2020

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Nuclear factor erythroid 2–related factor 2 is a positive regulator of human bile salt export pump expression

Hepatology (Baltimore, Md.), 2009-11, Vol.50 (5), p.1588-1596

2009

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The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/Akt/Smad pathway

Acta pharmacologica Sinica, 2015-04, Vol.36 (4), p.473-482

2015

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Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis

Journal of hepatology, 2015-12, Vol.63 (6), p.1440-1448

2015

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ATP8B1 Deficiency Disrupts the Bile Canalicular Membrane Bilayer Structure in Hepatocytes, But FXR Expression and Activity Are Maintained

Gastroenterology (New York, N.Y. 1943), 2009-03, Vol.136 (3), p.1060-1069.e4

2009

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Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion

Hepatology (Baltimore, Md.), 2013-06, Vol.57 (6), p.2418-2426

2013

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Elevated hepatic multidrug resistance-associated protein 3/ATP-binding cassette subfamily C 3 expression in human obstructive cholestasis is mediated through tumor necrosis factor alpha and c-Jun NH2-terminal kinase/stress-activated protein kinase-signaling pathway

Hepatology (Baltimore, Md.), 2012-05, Vol.55 (5), p.1485-1494

2012

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A novel ASBT inhibitor, IMB17-15, repressed nonalcoholic fatty liver disease development in high-fat diet-fed Syrian golden hamsters

Acta pharmacologica Sinica, 2019-07, Vol.40 (7), p.895-907

2019

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Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms

Journal of lipid research, 2010-08, Vol.51 (8), p.2265-2274

2010

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Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression

American journal of physiology: Gastrointestinal and liver physiology, 2010-07, Vol.299 (1), p.G126-G135

2010

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The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology

Biochimica et biophysica acta. Molecular basis of disease, 2021-05, Vol.1867 (5), p.166085-166085, Article 166085

2021

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Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis

Hepatology (Baltimore, Md.), 2006-05, Vol.43 (5), p.1013-1021

2006

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Hepatic TNFRSF12A promotes bile acid-induced hepatocyte pyroptosis through NFκB/Caspase-1/GSDMD signaling in cholestasis

Cell death discovery, 2023-01, Vol.9 (1), p.26-26, Article 26

2023

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Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2)[S]

Journal of lipid research, 2012-08, Vol.53 (8), p.1535-1542

2012

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SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface

JCI insight, 2022-08, Vol.7 (15)

2022

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Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis

Journal of hepatology, 2021-03, Vol.74 (3), p.550-559

2021

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Mechanisms of bile acid mediated inflammation in the liver

Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response

Cenicriviroc, a cytokine receptor antagonist, potentiates all‐trans retinoic acid in reducing liver injury in cholestatic rodents

Bile Infarcts: New Insights Into the Pathogenesis of Obstructive Cholestasis

Cytoprotective Effect of Antioxidant Pentapeptides from the Protein Hydrolysate of Swim Bladders of Miiuy Croaker (Miichthys miiuy) against H2O2-Mediated Human Umbilical Vein Endothelial Cell (HUVEC) Injury

A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis

Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct–ligated rats and human hepatic cells

A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis

Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis

Purification of antioxidant peptides of Moringa oleifera seeds and their protective effects on H2O2 oxidative damaged Chang liver cells

Nuclear factor erythroid 2–related factor 2 is a positive regulator of human bile salt export pump expression

The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/Akt/Smad pathway

Canalicular membrane MRP2/ABCC2 internalization is determined by Ezrin Thr567 phosphorylation in human obstructive cholestasis

ATP8B1 Deficiency Disrupts the Bile Canalicular Membrane Bilayer Structure in Hepatocytes, But FXR Expression and Activity Are Maintained

Adult sea lamprey tolerates biliary atresia by altering bile salt composition and renal excretion

Elevated hepatic multidrug resistance-associated protein 3/ATP-binding cassette subfamily C 3 expression in human obstructive cholestasis is mediated through tumor necrosis factor alpha and c-Jun NH2-terminal kinase/stress-activated protein kinase-signaling pathway

A novel ASBT inhibitor, IMB17-15, repressed nonalcoholic fatty liver disease development in high-fat diet-fed Syrian golden hamsters

Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms

Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression

The role of the retinoid receptor, RAR/RXR heterodimer, in liver physiology

Mrp4-/- mice have an impaired cytoprotective response in obstructive cholestasis

Hepatic TNFRSF12A promotes bile acid-induced hepatocyte pyroptosis through NFκB/Caspase-1/GSDMD signaling in cholestasis

Evolution of substrate specificity for the bile salt transporter ASBT (SLC10A2)[S]

SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface

Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis

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