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Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets

The Journal of biological chemistry, 1994-06, Vol.269 (22), p.15619-15624

1994

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Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action

Molecular pharmacology, 2001-01, Vol.59 (1), p.144-152

2001

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Quinolinic acid in cerebrospinal fluid and serum in HIV-1 Infection: Relationship to clinical and neurological status

Annals of neurology, 1991-02, Vol.29 (2), p.202-209

1991

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Description of a 96-Well Plate Assay to Measure Cytochrome P4503A Inhibition in Human Liver Microsomes Using a Selective Fluorescent Probe

Analytical biochemistry, 1999-12, Vol.276 (2), p.215-226

1999

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Refinement of an in vitro cell model for cytochrome P450 induction

Drug metabolism and disposition, 1998-05, Vol.26 (5), p.490

1998

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Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells

Biochemical pharmacology, 1996-10, Vol.52 (7), p.1113-1125

1996

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Enzyme kinetics of cytochrome P450-mediated reactions

Current drug metabolism, 2001-03, Vol.2 (1), p.17-36

2001

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Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid

Molecular pharmacology, 1994-02, Vol.45 (2), p.245-254

1994

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Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: leading to structural optimization

Drug metabolism and disposition, 2001-03, Vol.29 (3), p.232

2001

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In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663)

Bioorganic & medicinal chemistry letters, 2001-04, Vol.11 (8), p.1059-1062

2001

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Dioxabicyclooctanyl Naphthalenenitriles as Nonredox 5-Lipoxygenase Inhibitors: Structure−Activity Relationship Study Directed toward the Improvement of Metabolic Stability

Journal of medicinal chemistry, 1996-09, Vol.39 (20), p.3951-3970

1996

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Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx ™)

Bioorganic & medicinal chemistry letters, 2000-12, Vol.10 (23), p.2683-2686

2000

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Oxidative bioactivation of the lactol prodrug of a lactone cyclooxygenase-2 inhibitor

Drug metabolism and disposition, 1999-03, Vol.27 (3), p.403

1999

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Mass spectrometric analysis of arachidonyl-containing phospholipids in human U937 cells

Journal of mass spectrometry., 1999-05, Vol.34 (5), p.521-536

1999

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Purification and Characterization of Recombinant Human Cyclooxygenase-2

Archives of biochemistry and biophysics, 1994-11, Vol.315 (1), p.111-118

1994

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Microsomal metabolism of the 5-lipoxygenase inhibitors L-746,530 and L-739,010 to reactive intermediates that covalently bind to protein: the role of the 6,8-dioxabicyclo[3.2.1]octanyl moiety

Drug metabolism and disposition, 1995-12, Vol.23 (12), p.1325

1995

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In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization

Drug metabolism and disposition, 2001-05, Vol.29 (5), p.638

2001

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In vitro and in vivo biotransformations of the naphthalenic lignan lactone 5-lipoxygenase inhibitor, L-702,539

Drug metabolism and disposition, 1995-01, Vol.23 (1), p.65

1995

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Verlukast (MK-0679) conjugation with glutathione by rat liver and kidney cytosols and excretion in the bile

Drug metabolism and disposition, 1995-10, Vol.23 (10), p.1085

1995

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Application of rat hepatocyte culture to predict in vivo metabolic auto-induction: studies with DFP, a cyclooxygenase-2 inhibitor

Drug metabolism and disposition, 2001-02, Vol.29 (2), p.159

2001

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Characterization of verlukast metabolites arising from an epoxide intermediate produced with hepatic microsomes from beta-naphthoflavone-treated rodents (P-4501A1)

Drug metabolism and disposition, 1993-09, Vol.21 (5), p.861

1993

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Integrated Application of Capillary HPLC/Continuous-Flow Liquid Secondary Ion Mass Spectrometry to Discovery Stage Metabolism Studies

Analytical chemistry (Washington), 1995-09, Vol.67 (17), p.2931-2936

1995

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A comparison of thermospray and fast atom bombardment mass spectrometry as solution-dependent ionization techniques

Analytical chemistry (Washington), 1984-12, Vol.56 (14), p.2759-2762

1984

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A general approach to calculating isotopic distributions for mass spectrometry

International journal of mass spectrometry and ion physics, 1983-09, Vol.52 (2), p.337-349

Yergey, James A.

1983

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Sustained increases in cerebrospinal fluid quinolinic acid concentrations in rhesus macaques ( Macaca mulatta) naturally infected with simian retrovirus type-D

Brain research, 1990-10, Vol.531 (1), p.148-158

1990

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Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets

Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action

Quinolinic acid in cerebrospinal fluid and serum in HIV-1 Infection: Relationship to clinical and neurological status

Description of a 96-Well Plate Assay to Measure Cytochrome P4503A Inhibition in Human Liver Microsomes Using a Selective Fluorescent Probe

Refinement of an in vitro cell model for cytochrome P450 induction

Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells

Enzyme kinetics of cytochrome P450-mediated reactions

Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid

Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: leading to structural optimization

In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663)

Dioxabicyclooctanyl Naphthalenenitriles as Nonredox 5-Lipoxygenase Inhibitors: Structure−Activity Relationship Study Directed toward the Improvement of Metabolic Stability

Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx ™)

Oxidative bioactivation of the lactol prodrug of a lactone cyclooxygenase-2 inhibitor

Mass spectrometric analysis of arachidonyl-containing phospholipids in human U937 cells

Purification and Characterization of Recombinant Human Cyclooxygenase-2

Microsomal metabolism of the 5-lipoxygenase inhibitors L-746,530 and L-739,010 to reactive intermediates that covalently bind to protein: the role of the 6,8-dioxabicyclo[3.2.1]octanyl moiety

In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization

In vitro and in vivo biotransformations of the naphthalenic lignan lactone 5-lipoxygenase inhibitor, L-702,539

Verlukast (MK-0679) conjugation with glutathione by rat liver and kidney cytosols and excretion in the bile

Application of rat hepatocyte culture to predict in vivo metabolic auto-induction: studies with DFP, a cyclooxygenase-2 inhibitor

Characterization of verlukast metabolites arising from an epoxide intermediate produced with hepatic microsomes from beta-naphthoflavone-treated rodents (P-4501A1)

Integrated Application of Capillary HPLC/Continuous-Flow Liquid Secondary Ion Mass Spectrometry to Discovery Stage Metabolism Studies

A comparison of thermospray and fast atom bombardment mass spectrometry as solution-dependent ionization techniques

A general approach to calculating isotopic distributions for mass spectrometry

Sustained increases in cerebrospinal fluid quinolinic acid concentrations in rhesus macaques ( Macaca mulatta) naturally infected with simian retrovirus type-D

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