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Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors

Nature communications, 2020-01, Vol.11 (1), p.564-564, Article 564

2020

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PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

Nature (London), 2018-07, Vol.559 (7714), p.423-427

2018

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An electron transfer path connects subunits of a mycobacterial respiratory supercomplex

Science (American Association for the Advancement of Science), 2018-11, Vol.362 (6418)

2018

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Correlating Glycoforms of DC‐SIGN with Stability Using a Combination of Enzymatic Digestion and Ion Mobility Mass Spectrometry

Angewandte Chemie International Edition, 2020-09, Vol.59 (36), p.15560-15564

International ed. in English, 2020

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Combining native and 'omics' mass spectrometry to identify endogenous ligands bound to membrane proteins

Nature methods, 2020-05, Vol.17 (5), p.505-508

2020

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Infrared Multiphoton Dissociation Enables Top‐Down Characterization of Membrane Protein Complexes and G Protein‐Coupled Receptors

Angewandte Chemie International Edition, 2023-09, Vol.62 (36), p.e202305694-n/a

International ed. in English, 2023

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Native Desorption Electrospray Ionization Liberates Soluble and Membrane Protein Complexes from Surfaces

Angewandte Chemie International Edition, 2017-11, Vol.56 (46), p.14463-14468

International ed. in English, 2017

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Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization

Nature communications, 2021-01, Vol.12 (1), p.629-629, Article 629

2021

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Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells

Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (28), p.11332-11337

2011

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Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics

Nature communications, 2015-03, Vol.6 (1), p.6622-6622, Article 6622

2015

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Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition

Proceedings of the National Academy of Sciences - PNAS, 2015-06, Vol.112 (22), p.6955-6960

2015

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High-Throughput Native Mass Spectrometry Screening in Drug Discovery

Frontiers in molecular biosciences, 2022-04, Vol.9, p.837901

2022

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Phosphoproteomics Reveals HMGA1, a CK2 Substrate, as a Drug-Resistant Target in Non-Small Cell Lung Cancer

Scientific reports, 2017-03, Vol.7 (1), p.44021-44021, Article 44021

2017

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G Protein-Coupled Receptor Pharmacology-Insights from Mass Spectrometry

Pharmacological reviews, 2023-05, Vol.75 (3), p.397-415

2023

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Electrospray ionization of native membrane proteins proceeds via a charge equilibration step

RSC advances, 2022, Vol.12 (16), p.9671-9680

2022

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Cell-permeable probe for identification and imaging of sialidases

Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (7), p.2466-2471

2013

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State-dependent Lipid Interactions with the A2a Receptor Revealed by MD Simulations Using In Vivo-Mimetic Membranes

Structure (London), 2019-02, Vol.27 (2), p.392-403.e3

2019

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Structural insights into the lipid and ligand regulation of serotonin receptors

Nature (London), 2021-04, Vol.592 (7854), p.469-473

2021

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Differential Receptor Binding Affinities of Influenza Hemagglutinins on Glycan Arrays

Journal of the American Chemical Society, 2010-10, Vol.132 (42), p.14849-14856

2010

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Ligand binding to a G protein-coupled receptor captured in a mass spectrometer

Science advances, 2017-06, Vol.3 (6), p.e1701016-e1701016

2017

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Infrared Multiphoton Dissociation Enables Top‐Down Characterization of Membrane Protein Complexes and G Protein‐Coupled Receptors

Angewandte Chemie, 2023-09, Vol.135 (36), p.e202305694-n/a

2023

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Correlating Glycoforms of DC‐SIGN with Stability Using a Combination of Enzymatic Digestion and Ion Mobility Mass Spectrometry

Angewandte Chemie, 2020-09, Vol.132 (36), p.15690-15694

2020

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Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor

Nature chemistry, 2022-12, Vol.14 (12), p.1375-1382

2022

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Detergent-free Lipodisq Nanoparticles Facilitate High-Resolution Mass Spectrometry of Folded Integral Membrane Proteins

Nano letters, 2021-04, Vol.21 (7), p.2824-2831

2021

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RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases

Nucleic acids research, 2023-11, Vol.51 (21), p.11717-11731

2023

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Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

An electron transfer path connects subunits of a mycobacterial respiratory supercomplex

Correlating Glycoforms of DC‐SIGN with Stability Using a Combination of Enzymatic Digestion and Ion Mobility Mass Spectrometry

Combining native and 'omics' mass spectrometry to identify endogenous ligands bound to membrane proteins

Infrared Multiphoton Dissociation Enables Top‐Down Characterization of Membrane Protein Complexes and G Protein‐Coupled Receptors

Native Desorption Electrospray Ionization Liberates Soluble and Membrane Protein Complexes from Surfaces

Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization

Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells

Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics

Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition

High-Throughput Native Mass Spectrometry Screening in Drug Discovery

Phosphoproteomics Reveals HMGA1, a CK2 Substrate, as a Drug-Resistant Target in Non-Small Cell Lung Cancer

G Protein-Coupled Receptor Pharmacology-Insights from Mass Spectrometry

Electrospray ionization of native membrane proteins proceeds via a charge equilibration step

Cell-permeable probe for identification and imaging of sialidases

State-dependent Lipid Interactions with the A2a Receptor Revealed by MD Simulations Using In Vivo-Mimetic Membranes

Structural insights into the lipid and ligand regulation of serotonin receptors

Differential Receptor Binding Affinities of Influenza Hemagglutinins on Glycan Arrays

Ligand binding to a G protein-coupled receptor captured in a mass spectrometer

Infrared Multiphoton Dissociation Enables Top‐Down Characterization of Membrane Protein Complexes and G Protein‐Coupled Receptors

Correlating Glycoforms of DC‐SIGN with Stability Using a Combination of Enzymatic Digestion and Ion Mobility Mass Spectrometry

Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor

Detergent-free Lipodisq Nanoparticles Facilitate High-Resolution Mass Spectrometry of Folded Integral Membrane Proteins

RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases

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