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Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney

Arthritis research & therapy, 2016-10, Vol.18 (1), p.214-214, Article 214

2016

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The Effect of Lesinurad in Combination With Allopurinol on Serum Uric Acid Levels in Patients With Gout

Journal of clinical pharmacology, 2018-09, Vol.58 (9), p.1164-1170

2018

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In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters

Clinical drug investigation, 2016-06, Vol.36 (6), p.443-452

2016

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Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males

Drug design, development and therapy, 2015-01, Vol.9 (default), p.3423-3434

2015

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Phase 2a Randomized Controlled Trial of Short-Term Activity, Safety, and Pharmacokinetics of a Novel Nonnucleoside Reverse Transcriptase Inhibitor, RDEA806, in HIV-1-Positive, Antiretroviral-Naïve Subjects

Antimicrobial Agents and Chemotherapy, 2010-08, Vol.54 (8), p.3170-3178

2010

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The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS

Drug metabolism letters, 2019, Vol.13 (2), p.111-122

2019

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A Novel Nonnucleoside Analogue That Inhibits Human Immunodeficiency Virus Type 1 Isolates Resistant to Current Nonnucleoside Reverse Transcriptase Inhibitors

Antimicrobial Agents and Chemotherapy, 2007-02, Vol.51 (2), p.429-437

2007

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Pharmacodynamic, pharmacokinetic and tolerability evaluation of concomitant administration of lesinurad and febuxostat in gout patients with hyperuricaemia

Rheumatology (Oxford, England), 2014-12, Vol.53 (12), p.2167-2174

2014

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RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of Cancer

Cancer research (Chicago, Ill.), 2009-09, Vol.69 (17), p.6839-6847

2009

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Metabolic Activation of Pradefovir by CYP3A4 and Its Potential as an Inhibitor or Inducer

Antimicrobial Agents and Chemotherapy, 2006-09, Vol.50 (9), p.2926-2931

2006

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LC–MS/MS method for simultaneous determination of viramidine and ribavirin levels in monkey red blood cells

Journal of pharmaceutical and biomedical analysis, 2007-02, Vol.43 (3), p.1057-1064

2007

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Sensitive and specific LC–MS/MS method for the simultaneous measurements of viramidine and ribavirin in human plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006-02, Vol.832 (1), p.17-23

2006

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Pharmacokinetics and Safety of Viramidine, a Prodrug of Ribavirin, in Healthy Volunteers

Journal of clinical pharmacology, 2004-03, Vol.44 (3), p.265-275

2004

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Multicenter Phase I Trial of the Mitogen-Activated Protein Kinase 1/2 Inhibitor BAY 86-9766 in Patients with Advanced Cancer

Clinical cancer research, 2013-03, Vol.19 (5), p.1232-1243

2013

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P450 Phenotyping of the Metabolism of Selegiline to Desmethylselegiline and Methamphetamine

DRUG METABOLISM AND PHARMACOKINETICS, 2007-01, Vol.22 (2), p.78-87

2007

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Absorption, Metabolism, and Excretion of [14C]Viramidine in Humans

Antimicrobial Agents and Chemotherapy, 2006-07, Vol.50 (7), p.2368-2373

2006

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A Phase I Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Combination Therapy with Refametinib plus Sorafenib in Patients with Advanced Cancer

Clinical cancer research, 2016-05, Vol.22 (10), p.2368-2376

2016

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Disposition and Metabolic Profiles of [14C]Viramidine and [14C]Ribavirin in Rat and Monkey Red Blood Cells and Liver

Antimicrobial Agents and Chemotherapy, 2004-05, Vol.48 (5), p.1872-1875

2004

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Pharmacokinetics of Pradefovir and PMEA in Healthy Volunteers After Oral Dosing of Pradefovir

Journal of clinical pharmacology, 2005-11, Vol.45 (11), p.1250-1258

2005

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Determination of N-acetyl retigabine in dog plasma by LC/MS/MS following off-line μElution 96-well solid phase extraction

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007-06, Vol.852 (1), p.465-472

2007

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Viramidine, a Prodrug of Ribavirin, Shows Better Liver-Targeting Properties and Safety Profiles Than Ribavirin in Animals

Antiviral chemistry & chemotherapy, 2003-06, Vol.14 (3), p.145-152

2003

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Pharmacokinetics and Metabolism of [14C]Viramidine in Rats and Cynomolgus Monkeys

Antimicrobial Agents and Chemotherapy, 2003-08, Vol.47 (8), p.2458-2463

2003

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Erratum to: Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney

Arthritis research & therapy, 2016-10, Vol.18 (1), p.236-236, Article 236

2016

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Pharmacokinetics and Metabolism of [14C]Ribavirin in Rats and Cynomolgus Monkeys

Antimicrobial Agents and Chemotherapy, 2003-04, Vol.47 (4), p.1395-1398

2003

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Ascending Multiple-Dose Pharmacokinetics of Viramidine, a Prodrug of Ribavirin, in Adult Subjects With Compensated Hepatitis C Infection

Journal of clinical pharmacology, 2005-03, Vol.45 (3), p.275-285

2005

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Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney

The Effect of Lesinurad in Combination With Allopurinol on Serum Uric Acid Levels in Patients With Gout

In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters

Pharmacokinetics, pharmacodynamics, and safety of lesinurad, a selective uric acid reabsorption inhibitor, in healthy adult males

Phase 2a Randomized Controlled Trial of Short-Term Activity, Safety, and Pharmacokinetics of a Novel Nonnucleoside Reverse Transcriptase Inhibitor, RDEA806, in HIV-1-Positive, Antiretroviral-Naïve Subjects

The Effects of Special Patient Population Plasma on Pharmacokinetic Quantifications Using LC-MS/MS

A Novel Nonnucleoside Analogue That Inhibits Human Immunodeficiency Virus Type 1 Isolates Resistant to Current Nonnucleoside Reverse Transcriptase Inhibitors

Pharmacodynamic, pharmacokinetic and tolerability evaluation of concomitant administration of lesinurad and febuxostat in gout patients with hyperuricaemia

RDEA119/BAY 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 for the Treatment of Cancer

Metabolic Activation of Pradefovir by CYP3A4 and Its Potential as an Inhibitor or Inducer

LC–MS/MS method for simultaneous determination of viramidine and ribavirin levels in monkey red blood cells

Sensitive and specific LC–MS/MS method for the simultaneous measurements of viramidine and ribavirin in human plasma

Pharmacokinetics and Safety of Viramidine, a Prodrug of Ribavirin, in Healthy Volunteers

Multicenter Phase I Trial of the Mitogen-Activated Protein Kinase 1/2 Inhibitor BAY 86-9766 in Patients with Advanced Cancer

P450 Phenotyping of the Metabolism of Selegiline to Desmethylselegiline and Methamphetamine

Absorption, Metabolism, and Excretion of [14C]Viramidine in Humans

A Phase I Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Combination Therapy with Refametinib plus Sorafenib in Patients with Advanced Cancer

Disposition and Metabolic Profiles of [14C]Viramidine and [14C]Ribavirin in Rat and Monkey Red Blood Cells and Liver

Pharmacokinetics of Pradefovir and PMEA in Healthy Volunteers After Oral Dosing of Pradefovir

Determination of N-acetyl retigabine in dog plasma by LC/MS/MS following off-line μElution 96-well solid phase extraction

Viramidine, a Prodrug of Ribavirin, Shows Better Liver-Targeting Properties and Safety Profiles Than Ribavirin in Animals

Pharmacokinetics and Metabolism of [14C]Viramidine in Rats and Cynomolgus Monkeys

Erratum to: Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney

Pharmacokinetics and Metabolism of [14C]Ribavirin in Rats and Cynomolgus Monkeys

Ascending Multiple-Dose Pharmacokinetics of Viramidine, a Prodrug of Ribavirin, in Adult Subjects With Compensated Hepatitis C Infection

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