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AAA-ATPases in Protein Degradation

Frontiers in molecular biosciences, 2017-06, Vol.4, p.42-42

2017

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Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications

Antimicrobial agents and chemotherapy, 2019-07, Vol.63 (7)

2019

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GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro

Scientific reports, 2017-09, Vol.7 (1), p.12235-12, Article 12235

2017

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C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir

Journal of virology, 2016-03, Vol.90 (5), p.2180-2194

2016

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P2′ Benzene Carboxylic Acid Moiety Is Associated with Decrease in Cellular Uptake: Evaluation of Novel Nonpeptidic HIV-1 Protease Inhibitors Containing P2 bis-Tetrahydrofuran Moiety

Antimicrobial Agents and Chemotherapy, 2013-10, Vol.57 (10), p.4920-4927

2013

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Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design

Vaccines (Basel), 2022-05, Vol.10 (6), p.841

2022

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Leveraging the potential of bacterial lateral gene transfer in boosting the efficacy of an edible probiotic prototype yogurt vaccine for COVID-19

Biochemical and biophysical research communications, 2024-11, Vol.734, p.150622, Article 150622

2024

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Novel HIV-1 Protease Inhibitors (PIs) Containing a Bicyclic P2 Functional Moiety, Tetrahydropyrano-Tetrahydrofuran, That Are Potent against Multi-PI-Resistant HIV-1 Variants

Antimicrobial Agents and Chemotherapy, 2011-04, Vol.55 (4), p.1717-1727

2011

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Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants

Acta crystallographica. Section D, Biological crystallography., 2011-06, Vol.67 (6), p.524-532

2011

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Ubiquitin orchestrates proteasome dynamics between proliferation and quiescence in yeast

Molecular biology of the cell, 2017-09, Vol.28 (19), p.2479-2491

2017

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Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors In Vitro

Antimicrobial agents and chemotherapy, 2022-02, Vol.66 (2), p.e0171521

2022

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Proteasome dynamics between proliferation and quiescence stages of Saccharomyces cerevisiae

Critical reviews in biochemistry and molecular biology, 2016-11, Vol.51 (6), p.497-512

2016

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A Novel Polar Core and Weakly Fixed C-Tail in Squid Arrestin Provide New Insight into Interaction with Rhodopsin

Journal of molecular biology, 2018-10, Vol.430 (21), p.4102-4118

2018

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A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413

Antimicrobial agents and chemotherapy, 2016-12, Vol.60 (12), p.7046-7059

2016

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Mechanism-Based Inhibitors of the Aspartyl Protease Plasmepsin II as Potential Antimalarial Agents

Journal of medicinal chemistry, 2010-05, Vol.53 (10), p.4234-4247

2010

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A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV

Antimicrobial agents and chemotherapy, 2014-07, Vol.58 (7), p.3679-3688

2014

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Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes

Biochemical and biophysical research communications, 2013-01, Vol.430 (3), p.1022-1027

2013

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Crystal structure of the extracellular domain of human myelin protein zero

Proteins, structure, function, and bioinformatics, 2012-01, Vol.80 (1), p.307-313

2012

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Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: Mechanism of drug recognition and resistance

Biochemical and biophysical research communications, 2013-07, Vol.437 (2), p.199-204

2013

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Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex

Biochemical and biophysical research communications, 2013-02, Vol.431 (2), p.232-238

2013

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Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia

Blood, 2006-02, Vol.107 (4), p.1570-1581

2006

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Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds

Biochemical and biophysical research communications, 2012-05, Vol.421 (3), p.413-417

2012

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P1 and P1′ para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: Structure-based virtual screening of extended lopinavir analogs against multi-drug resistant HIV-1 protease

Journal of molecular graphics & modelling, 2014-02, Vol.47, p.18-24

2014

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Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease

Biochemical and biophysical research communications, 2013-09, Vol.438 (4), p.703-708

2013

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AAA-ATPases in Protein Degradation

Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications

A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency

GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro

C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir

P2′ Benzene Carboxylic Acid Moiety Is Associated with Decrease in Cellular Uptake: Evaluation of Novel Nonpeptidic HIV-1 Protease Inhibitors Containing P2 bis-Tetrahydrofuran Moiety

Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design

Leveraging the potential of bacterial lateral gene transfer in boosting the efficacy of an edible probiotic prototype yogurt vaccine for COVID-19

Novel HIV-1 Protease Inhibitors (PIs) Containing a Bicyclic P2 Functional Moiety, Tetrahydropyrano-Tetrahydrofuran, That Are Potent against Multi-PI-Resistant HIV-1 Variants

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants

Ubiquitin orchestrates proteasome dynamics between proliferation and quiescence in yeast

Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors In Vitro

Proteasome dynamics between proliferation and quiescence stages of Saccharomyces cerevisiae

A Novel Polar Core and Weakly Fixed C-Tail in Squid Arrestin Provide New Insight into Interaction with Rhodopsin

A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413

Mechanism-Based Inhibitors of the Aspartyl Protease Plasmepsin II as Potential Antimalarial Agents

A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV

Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes

Crystal structure of the extracellular domain of human myelin protein zero

Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: Mechanism of drug recognition and resistance

Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex

Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia

Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds

P1 and P1′ para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: Structure-based virtual screening of extended lopinavir analogs against multi-drug resistant HIV-1 protease

Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease

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