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Practical Synthetic Method for the Preparation of Pyrone Diesters: An Efficient Synthetic Route for the Synthesis of Dolutegravir Sodium

Organic process research & development, 2019-04, Vol.23 (4), p.565-570

2019

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Practical and Scalable Synthetic Method for Preparation of Dolutegravir Sodium: Improvement of a Synthetic Route for Large-Scale Synthesis

Organic process research & development, 2019-04, Vol.23 (4), p.558-564

2019

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Practical Synthesis of Ethyl 1-( tert -Butoxycarbonyl)-4-(1-pyrrolidinyl)-4-piperidineacetate, an Intermediate of a Novel Antiarteriosclerotic, Utilizing Aza-Michael Addition Promoted by LiBr

Chemistry letters, 2012-12, Vol.41 (12), p.1703-1705

2012

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Efficient Synthesis of Acrylates Bearing an Aryl or Heteroaryl Moiety: One-Pot Method from Aromatics and Heteroaromatics Using Formylation and the Horner-Wadsworth-Emmons Reaction

Heterocycles, 2021, Vol.102 (3), p.527

2021

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Development of Practical Synthetic Method for the Preparation of Dolutegravir Sodium, a Potent HIV-1 Integrase Inhibitor for the Treatment of HIV Infectious Disease

Yūki gōsei kagaku kyōkaishi, 2020-01, Vol.78 (1), p.2-10

2020

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A Mild Method for the Synthesis of Carbamate-Protected Guanidines Using the Burgess Reagent

Organic letters, 2014-04, Vol.16 (7), p.1868-1871

2014

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Practical Manufacturing Process for Baloxavir Marboxil: Efficient Route to a Tricyclic Triazinanone Scaffold

Organic process research & development, 2024-06, Vol.28 (6), p.2128-2138

2024

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Practical Manufacturing Process for Baloxavir Marboxil: Effective Selection and Replacement of Protective Group toward Enhancement of Crystallization-Induced Diastereomer Transformation

Organic process research & development, 2024-06, Vol.28 (6), p.2139-2149

2024

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Novel semi-synthetic glycopeptide antibiotics active against methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE): doubly-modified water-soluble derivatives of chloroorienticin B

Bioorganic & medicinal chemistry letters, 2002-11, Vol.12 (21), p.3027-3031

2002

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Synthesis and in vitro/in vivo antibacterial activity of oxazolidinones having thiocarbamate at C-5 on the A-ring and an amide- or urea-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane as the C-ring

European journal of medicinal chemistry, 2013-11, Vol.69, p.262-277

2013

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Enantioselective protonation of achiral lithium enolates using a chiral amine in the presence of lithium bromide

Tetrahedron: asymmetry, 1993, Vol.4 (1), p.35-38

1993

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Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit

European journal of medicinal chemistry, 2013-05, Vol.63, p.811-825

2013

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Stereoselective reactions. 30. Enantioselective alkylation of the lithium enolates of six-membered cyclic ketones using tetradentate chiral amines in the presence of lithium bromide

Tetrahedron, 1998-03, Vol.54 (11), p.2449-2458

1998

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A Catalytic Asymmetric Wagner−Meerwein Shift

Journal of the American Chemical Society, 2001-07, Vol.123 (29), p.7162-7163

2001

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A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: Synthesis and structure–activity relationships

Bioorganic & medicinal chemistry, 2007-11, Vol.15 (21), p.6716-6732

2007

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Stereoselective Reactions. XXII. Design and Synthesis of Chiral Chelated Lithium Amides for Enantioselective Reactions

Chemical and Pharmaceutical Bulletin, 1994/03/15, Vol.42(3), pp.690-693

1994

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A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other Gram-negative pathogens. Part 2: Synthesis and structure–activity relationships

Bioorganic & medicinal chemistry, 2008-02, Vol.16 (4), p.1632-1647

2008

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9-Oxime-3-ketolides: Modification at the C-11,12-diol moiety and antibacterial activities against key respiratory pathogens

Bioorganic & medicinal chemistry, 2005-11, Vol.13 (21), p.6054-6063

2005

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A new type of ketolides bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether synthesis and structure–activity relationships

Bioorganic & medicinal chemistry, 2005-12, Vol.13 (24), p.6615-6628

2005

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An unusual regioselectivity in the Pd-catalyzed cross coupling of alkynes. A correction

Tetrahedron letters, 2001-06, Vol.42 (23), p.3775-3778

2001

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An efficient and practical method for solid-phase synthesis of tripeptide-bearing glycopeptide antibiotics: combinatorial parallel synthesis of carboxamide derivatives of chloroorienticin B

Bioorganic & medicinal chemistry letters, 2002-11, Vol.12 (21), p.3033-3036

2002

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ChemInform Abstract: A Mild Method for the Synthesis of Carbamate-Protected Guanidines Using the Burgess Reagent

ChemInform, 2014-09, Vol.45 (39), p.no-no

2014

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Novel semi-synthetic glycopeptide antibiotics active against methicillin-resistant s taphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE): doubly-modified water-soluble derivatives of chloroorienticin B

Bioorganic & medicinal chemistry letters, 2002, Vol.12 (21), p.3027-3031

2002

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ChemInform Abstract: Practical Synthesis of Ethyl 1-(tert-Butoxycarbonyl)-4-(1-pyrrolidinyl)-4-piperidineacetate, an Intermediate of a Novel Antiarteriosclerotic, Utilizing Aza-Michael Addition Promoted by LiBr

ChemInform, 2013-05, Vol.44 (20), p.no-no

2013

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新規合成抗菌薬 : 細胞壁合成酵素MurB阻害剤の探索(F・医薬化学)

ファルマシア, 2004/03/01, Vol.40(3), pp.261-262

安酸, 達郎

2004

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Practical Synthetic Method for the Preparation of Pyrone Diesters: An Efficient Synthetic Route for the Synthesis of Dolutegravir Sodium

Practical and Scalable Synthetic Method for Preparation of Dolutegravir Sodium: Improvement of a Synthetic Route for Large-Scale Synthesis

Practical Synthesis of Ethyl 1-( tert -Butoxycarbonyl)-4-(1-pyrrolidinyl)-4-piperidineacetate, an Intermediate of a Novel Antiarteriosclerotic, Utilizing Aza-Michael Addition Promoted by LiBr

Efficient Synthesis of Acrylates Bearing an Aryl or Heteroaryl Moiety: One-Pot Method from Aromatics and Heteroaromatics Using Formylation and the Horner-Wadsworth-Emmons Reaction

Development of Practical Synthetic Method for the Preparation of Dolutegravir Sodium, a Potent HIV-1 Integrase Inhibitor for the Treatment of HIV Infectious Disease

A Mild Method for the Synthesis of Carbamate-Protected Guanidines Using the Burgess Reagent

Practical Manufacturing Process for Baloxavir Marboxil: Efficient Route to a Tricyclic Triazinanone Scaffold

Practical Manufacturing Process for Baloxavir Marboxil: Effective Selection and Replacement of Protective Group toward Enhancement of Crystallization-Induced Diastereomer Transformation

Novel semi-synthetic glycopeptide antibiotics active against methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE): doubly-modified water-soluble derivatives of chloroorienticin B

Synthesis and in vitro/in vivo antibacterial activity of oxazolidinones having thiocarbamate at C-5 on the A-ring and an amide- or urea-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane as the C-ring

Enantioselective protonation of achiral lithium enolates using a chiral amine in the presence of lithium bromide

Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit

Stereoselective reactions. 30. Enantioselective alkylation of the lithium enolates of six-membered cyclic ketones using tetradentate chiral amines in the presence of lithium bromide

A Catalytic Asymmetric Wagner−Meerwein Shift

A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: Synthesis and structure–activity relationships

Stereoselective Reactions. XXII. Design and Synthesis of Chiral Chelated Lithium Amides for Enantioselective Reactions

A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other Gram-negative pathogens. Part 2: Synthesis and structure–activity relationships

9-Oxime-3-ketolides: Modification at the C-11,12-diol moiety and antibacterial activities against key respiratory pathogens

A new type of ketolides bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether synthesis and structure–activity relationships

An unusual regioselectivity in the Pd-catalyzed cross coupling of alkynes. A correction

An efficient and practical method for solid-phase synthesis of tripeptide-bearing glycopeptide antibiotics: combinatorial parallel synthesis of carboxamide derivatives of chloroorienticin B

ChemInform Abstract: A Mild Method for the Synthesis of Carbamate-Protected Guanidines Using the Burgess Reagent

Novel semi-synthetic glycopeptide antibiotics active against methicillin-resistant s taphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE): doubly-modified water-soluble derivatives of chloroorienticin B

ChemInform Abstract: Practical Synthesis of Ethyl 1-(tert-Butoxycarbonyl)-4-(1-pyrrolidinyl)-4-piperidineacetate, an Intermediate of a Novel Antiarteriosclerotic, Utilizing Aza-Michael Addition Promoted by LiBr

新規合成抗菌薬 : 細胞壁合成酵素MurB阻害剤の探索(F・医薬化学)

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