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Comparison of the stability of CYP105A1 and its variants engineered for production of active forms of vitamin D

Bioscience, biotechnology, and biochemistry, 2022-03, Vol.86 (4), p.444-454

2022

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The First Convergent Synthesis of 23,23-Difluoro-25-hydroxyvitamin D3 and Its 24-Hydroxy Derivatives: Preliminary Assessment of Biological Activities

Molecules (Basel, Switzerland), 2022-08, Vol.27 (16), p.5352

2022

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Expression of Clostridium acetobutylicum butanol synthetic genes in Escherichia coli

Applied microbiology and biotechnology, 2008, Vol.77 (6), p.1305-1316

2008

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In Silico Prediction of the Metabolic Resistance of Vitamin D Analogs against CYP3A4 Metabolizing Enzyme

International journal of molecular sciences, 2022-07, Vol.23 (14), p.7845

2022

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Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector

Scientific reports, 2023-10, Vol.13 (1), p.18528-18528, Article 18528

2023

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Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats

Scientific reports, 2022-07, Vol.12 (1), p.1-10, Article 12517

2022

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Synthesis of New 26,27-Difluoro- and 26,26,27,27-Tetrafluoro-25-hydroxyvitamin D3: Effects of Terminal Fluorine Atoms on Biological Activity and Half-life

Chemical and Pharmaceutical Bulletin, 2023/09/01, Vol.71(9), pp.717-723

2023

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Inhibitory effects of sesamin on CYP2C9-dependent 7-hydroxylation of S-warfarin

Drug metabolism and pharmacokinetics, 2020-08, Vol.35 (4), p.368-373

2020

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Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions

Scientific reports, 2020-03, Vol.10 (1), p.5677-5677, Article 5677

2020

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Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D3 Analogues and Their Stability to hCYP24A1-Dependent Catabolism

International journal of molecular sciences, 2021-11, Vol.22 (21), p.11863

2021

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Development of In Vitro and In Vivo Evaluation Systems for Vitamin D Derivatives and Their Application to Drug Discovery

International journal of molecular sciences, 2021-10, Vol.22 (21), p.11839

2021

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Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model

The Journal of steroid biochemistry and molecular biology, 2019-04, Vol.188, p.8-16

2019

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Expression of Rat Cyp27b1 in HepG2 Cells Using Adenovirus Vector and Its Application to Evaluation of Self-Made and Commercially Available Anti-Cyp27b1 Antibodies

Journal of nutritional science and vitaminology, 2023-01, Vol.69 (2), p.90-97

2023

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Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by CYP24A1 and CYP3A using Cyp24a1 knockout rats generated by CRISPR/Cas9 system

The Journal of biological chemistry, 2021-01, Vol.296, p.100668-100668, Article 100668

2021

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Functional analysis of vitamin D receptor (VDR) using adenovirus vector

The Journal of steroid biochemistry and molecular biology, 2023-06, Vol.230, p.106275-106275, Article 106275

2023

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Analysis of vitamin D receptor binding affinities of enzymatically synthesized triterpenes including ambrein and unnatural onoceroids

Scientific reports, 2024-01, Vol.14 (1), p.1419-1419, Article 1419

2024

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1,25-(OH)2D-24 Hydroxylase (CYP24A1) Deficiency as a Cause of Nephrolithiasis

Clinical journal of the American Society of Nephrology, 2013-04, Vol.8 (4), p.649-657

2013

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Introduction of fluorine atoms to vitamin D3 side-chain and synthesis of 24,24-difluoro-25-hydroxyvitamin D3

The Journal of steroid biochemistry and molecular biology, 2019-12, Vol.195, p.105477-105477, Article 105477

2019

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Whole-cell dependent biosynthesis of N- and S-oxides using human flavin containing monooxygenases expressing budding yeast

Drug metabolism and pharmacokinetics, 2020-06, Vol.35 (3), p.274-280

2020

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Metabolism of sesamin by cytochrome P450 in human liver microsomes

Drug metabolism and disposition, 2010-12, Vol.38 (12), p.2117

2010

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Metabolism of non-steroidal anti-inflammatory drugs (NSAIDs) by Streptomyces griseolus CYP105A1 and its variants

Drug metabolism and pharmacokinetics, 2022-08, Vol.45, p.100455-100455, Article 100455

2022

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Epicatechin gallate and epigallocatechin gallate are potent inhibitors of human arylacetamide deacetylase

Drug metabolism and pharmacokinetics, 2021-08, Vol.39, p.100397, Article 100397

2021

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Concise synthesis of 23-hydroxylated vitamin D3 metabolites

The Journal of steroid biochemistry and molecular biology, 2019-02, Vol.186, p.161-168

2019

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Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D2 Derivatives Modified at the Side Chain and the A-Ring

International journal of molecular sciences, 2020-01, Vol.21 (2), p.642

2020

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CYP24A1 as a potential target for cancer therapy

Anti-cancer agents in medicinal chemistry, 2014-01, Vol.14 (1), p.97

2014

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Comparison of the stability of CYP105A1 and its variants engineered for production of active forms of vitamin D

The First Convergent Synthesis of 23,23-Difluoro-25-hydroxyvitamin D3 and Its 24-Hydroxy Derivatives: Preliminary Assessment of Biological Activities

Expression of Clostridium acetobutylicum butanol synthetic genes in Escherichia coli

In Silico Prediction of the Metabolic Resistance of Vitamin D Analogs against CYP3A4 Metabolizing Enzyme

Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector

Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats

Synthesis of New 26,27-Difluoro- and 26,26,27,27-Tetrafluoro-25-hydroxyvitamin D3: Effects of Terminal Fluorine Atoms on Biological Activity and Half-life

Inhibitory effects of sesamin on CYP2C9-dependent 7-hydroxylation of S-warfarin

Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions

Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D3 Analogues and Their Stability to hCYP24A1-Dependent Catabolism

Development of In Vitro and In Vivo Evaluation Systems for Vitamin D Derivatives and Their Application to Drug Discovery

Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model

Expression of Rat Cyp27b1 in HepG2 Cells Using Adenovirus Vector and Its Application to Evaluation of Self-Made and Commercially Available Anti-Cyp27b1 Antibodies

Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by CYP24A1 and CYP3A using Cyp24a1 knockout rats generated by CRISPR/Cas9 system

Functional analysis of vitamin D receptor (VDR) using adenovirus vector

Analysis of vitamin D receptor binding affinities of enzymatically synthesized triterpenes including ambrein and unnatural onoceroids

1,25-(OH)2D-24 Hydroxylase (CYP24A1) Deficiency as a Cause of Nephrolithiasis

Introduction of fluorine atoms to vitamin D3 side-chain and synthesis of 24,24-difluoro-25-hydroxyvitamin D3

Whole-cell dependent biosynthesis of N- and S-oxides using human flavin containing monooxygenases expressing budding yeast

Metabolism of sesamin by cytochrome P450 in human liver microsomes

Metabolism of non-steroidal anti-inflammatory drugs (NSAIDs) by Streptomyces griseolus CYP105A1 and its variants

Epicatechin gallate and epigallocatechin gallate are potent inhibitors of human arylacetamide deacetylase

Concise synthesis of 23-hydroxylated vitamin D3 metabolites

Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D2 Derivatives Modified at the Side Chain and the A-Ring

CYP24A1 as a potential target for cancer therapy

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