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A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates

Science translational medicine, 2018-08, Vol.10 (456)

2018

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Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice

Haematologica (Roma), 2015-12, Vol.100 (12), p.1517

2015

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Structure-Based SAR in the Design of Selective or Bifunctional Nociceptin (NOP) Receptor Agonists

The AAPS journal, 2021-05, Vol.23 (3), p.68, Article 68

2021

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Synthesis and biological activity of new pyridone diaryl ether non-nucleoside inhibitors of HIV-1 reverse transcriptase

MedChemComm, 2010-07, Vol.1 (1), p.79-83

2010

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Discovery and Structure–Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson’s Disease Models

Journal of medicinal chemistry, 2020-03, Vol.63 (5), p.2688-2704

2020

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The α3β4 nAChR partial agonist AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats

Behavioural brain research, 2017-08, Vol.333, p.251-257

2017

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Functional Characterization of AT-1001, an α3β4 Nicotinic Acetylcholine Receptor Ligand, at Human α3β4 and α4β2 nAChR

Nicotine & tobacco research, 2015-03, Vol.17 (3), p.361-367

2015

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High affinity α3β4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice

Biochemical pharmacology, 2015-10, Vol.97 (4), p.531-541

2015

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Buprenorphine requires concomitant activation of NOP and MOP receptors to reduce cocaine consumption

Addiction biology, 2018-03, Vol.23 (2), p.585-595

2018

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AT‐1001: a high‐affinity α3β4 nAChR ligand with novel nicotine‐suppressive pharmacology

British journal of pharmacology, 2015-04, Vol.172 (7), p.1834-1845

2015

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AT-1001: a high-affinity alpha 3 beta 4 nAChR ligand with novel nicotine-suppressive pharmacology

British journal of pharmacology, 2015-04, Vol.172 (7), p.1834-1845

2015

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In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations

European journal of pharmacology, 2016-12, Vol.793, p.1-13

2016

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AT-1001: a high-affinity [alpha]3[beta]4 nAChR ligand with novel nicotine-suppressive pharmacology

British journal of pharmacology, 2015-04, Vol.172 (7), p.1834

2015

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Paralytic activity of (des-Glu1)conotoxin GI analogs in the mouse diaphragm

International Journal of Peptide and Protein Research, 1989-12, Vol.34 (6), p.455-462

1989

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The pharmacologic effect of deuterium substitution on 5-n-butyl-5-ethylbarbituric acid

Life sciences (1973), 1969-10, Vol.8 (19), p.1123-1128

1969

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Absence of isotope effects in the microsomal hydroxylation of acetanilide

Biochemical pharmacology, 1967-11, Vol.16 (11), p.2230-2233

1967

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THE SYNTHESIS OF 4"-DEOXYGENTAMICIN C1

The Journal of Antibiotics, 1973/12/25, Vol.26(12), pp.782-783

1973

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Semisynthetic aminoglycoside antibacterials. Part II. Synthesis of gentamicin X2 and related compounds

Perkin transactions. 1, 1976 (10), p.1097

1976

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Semisynthetic aminoglycoside antibacterials. Part V. Synthesis of pentosyl and related derivatives of garamine

Perkin transactions. 1, 1976 (10), p.1135

1976

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Synthesis and antiinflammatory activity of novel 12.beta.-substituted analogs of betamethasone

Journal of medicinal chemistry, 1990-07, Vol.33 (7), p.1852-1858

1990

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Aminoglycoside antibiotics: synthesis of nebramine, tobramycin and 4″-epi-tobramycin

Tetrahedron letters, 1977, Vol.18 (41), p.3607-3610

1977

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A method for the stereoselective synthesis of (E)-methylstilbene retinoids

Journal of organic chemistry, 1984-12, Vol.49 (26), p.5265-5267

1984

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Partial synthesis of fusidic acid

Tetrahedron letters, 1977, Vol.18 (17), p.1481-1484

1977

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Metabolic studies of tolbutamide in the rat

Biochemical pharmacology, 1967, Vol.16 (1), p.143-153

1967

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A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates

Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice

Structure-Based SAR in the Design of Selective or Bifunctional Nociceptin (NOP) Receptor Agonists

Synthesis and biological activity of new pyridone diaryl ether non-nucleoside inhibitors of HIV-1 reverse transcriptase

Discovery and Structure–Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson’s Disease Models

The α3β4 nAChR partial agonist AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats

Functional Characterization of AT-1001, an α3β4 Nicotinic Acetylcholine Receptor Ligand, at Human α3β4 and α4β2 nAChR

High affinity α3β4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice

Buprenorphine requires concomitant activation of NOP and MOP receptors to reduce cocaine consumption

AT‐1001: a high‐affinity α3β4 nAChR ligand with novel nicotine‐suppressive pharmacology

AT-1001: a high-affinity alpha 3 beta 4 nAChR ligand with novel nicotine-suppressive pharmacology

In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations

AT-1001: a high-affinity [alpha]3[beta]4 nAChR ligand with novel nicotine-suppressive pharmacology

Synthesis and biological activity of new pyridone diaryl ether non-nucleoside inhibitors of HIV-1 reverse transcriptaseElectronic supplementary information (ESI) available: Crystallographic data for the co-crystal structure of 2b and HIV-RT. See DOI: 10.1039/c0md00009d

Paralytic activity of (des-Glu1)conotoxin GI analogs in the mouse diaphragm

The pharmacologic effect of deuterium substitution on 5-n-butyl-5-ethylbarbituric acid

Absence of isotope effects in the microsomal hydroxylation of acetanilide

THE SYNTHESIS OF 4"-DEOXYGENTAMICIN C1

Semisynthetic aminoglycoside antibacterials. Part II. Synthesis of gentamicin X2 and related compounds

Semisynthetic aminoglycoside antibacterials. Part V. Synthesis of pentosyl and related derivatives of garamine

Synthesis and antiinflammatory activity of novel 12.beta.-substituted analogs of betamethasone

Aminoglycoside antibiotics: synthesis of nebramine, tobramycin and 4″-epi-tobramycin

A method for the stereoselective synthesis of (E)-methylstilbene retinoids

Partial synthesis of fusidic acid

Metabolic studies of tolbutamide in the rat

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