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Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer

Cancer discovery, 2016-01, Vol.6 (1), p.36-44

2016

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Antitumor Activity of RXDX-105 in Multiple Cancer Types with RET Rearrangements or Mutations

Clinical cancer research, 2017-06, Vol.23 (12), p.2981-2990

2017

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Identification and structure–activity relationships of substituted pyridones as inhibitors of Pim-1 kinase

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1679-1683

2007

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Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (22), p.5888-5891

2006

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Using Cyclooxygenase-2 Inhibitors as Molecular Platforms to Develop a New Class of Apoptosis-Inducing Agents

JNCI : Journal of the National Cancer Institute, 2002-12, Vol.94 (23), p.1745-1757

2002

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Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (7), p.1991-1995

2007

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Isothiazoles as active-site inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (1), p.28-33

2007

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Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

Science (American Association for the Advancement of Science), 2013-05, Vol.340 (6132), p.622-626

2013

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Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (21), p.5561-5566

2006

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Structure-based library design in efficient discovery of novel inhibitors

Methods in molecular biology (Clifton, N.J.), 2011, Vol.685, p.175

2011

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Structure–activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1663-1666

2007

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Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2‑HG in Vivo

ACS medicinal chemistry letters, 2012-10, Vol.3 (10), p.850-855

2012

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

Chemistry & biology, 2012-09, Vol.19 (9), p.1187-1198

2012

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An Optimized Protein Kinase C Activating Diacylglycerol Combining High Binding Affinity (K i) with Reduced Lipophilicity (log P)

Journal of medicinal chemistry, 2001-06, Vol.44 (12), p.1892-1904

2001

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Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (1), p.63-67

2007

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Identification of novel, selective and potent Chk2 inhibitors

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (1), p.172-175

2007

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Structural Identification of Two Metabolites of Catechins and Their Kinetics in Human Urine and Blood after Tea Ingestion

Chemical research in toxicology, 2000-03, Vol.13 (3), p.177-184

2000

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Structure-activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RAN-dependent RAN polymerase inhibitors

Bioorganic & medicinal chemistry letters, 2007, Vol.17 (6), p.1663-1666

2007

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Ab Initio Electronic Structure Calculations on Chlorocarbene−Ethylene and Chlorocarbene−Benzene Complexes

Journal of the American Chemical Society, 1999-07, Vol.121 (26), p.6269-6274

1999

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SbF 5 -Mediated Reactions of Oxafluorodiazirines

Organic letters, 2001-07, Vol.3 (15), p.2305-2308

2001

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Modulation of Carbenic Reactivity by π-Complexation to Aromatics

Journal of the American Chemical Society, 1998-02, Vol.120 (5), p.1088-1089

1998

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SbF5-Mediated Reactions of Oxafluorodiazirines

Organic letters, 2001-07, Vol.3 (15), p.2305-2308

2001

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Rearrangements of cyclopropylmethylchlorocarbene and dicyclopropylmethylchlorocarbene

Tetrahedron letters, 2001-12, Vol.42 (51), p.8923-8926

2001

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Computational Studies of Oxahalocarbene Fragmentation: Convergence of Theory and Experiment

Organic letters, 1999-11, Vol.1 (10), p.1603-1606

1999

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New Kinetics Methodologies Applied to Carbene Fragmentation Reactions

Journal of the American Chemical Society, 2000-11, Vol.122 (45), p.11256-11257

2000

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Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer

Antitumor Activity of RXDX-105 in Multiple Cancer Types with RET Rearrangements or Mutations

Identification and structure–activity relationships of substituted pyridones as inhibitors of Pim-1 kinase

Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors

Using Cyclooxygenase-2 Inhibitors as Molecular Platforms to Develop a New Class of Apoptosis-Inducing Agents

Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: Convergence of structure-based drug design and X-ray crystallographic study

Isothiazoles as active-site inhibitors of HCV NS5B polymerase

Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

Identification of isothiazole-4-carboxamidines derivatives as a novel class of allosteric MEK1 inhibitors

Structure-based library design in efficient discovery of novel inhibitors

Structure–activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors

Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2‑HG in Vivo

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

An Optimized Protein Kinase C Activating Diacylglycerol Combining High Binding Affinity (K i) with Reduced Lipophilicity (log P)

Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure

Identification of novel, selective and potent Chk2 inhibitors

Structural Identification of Two Metabolites of Catechins and Their Kinetics in Human Urine and Blood after Tea Ingestion

Structure-activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RAN-dependent RAN polymerase inhibitors

Ab Initio Electronic Structure Calculations on Chlorocarbene−Ethylene and Chlorocarbene−Benzene Complexes

SbF 5 -Mediated Reactions of Oxafluorodiazirines

Modulation of Carbenic Reactivity by π-Complexation to Aromatics

SbF5-Mediated Reactions of Oxafluorodiazirines

Rearrangements of cyclopropylmethylchlorocarbene and dicyclopropylmethylchlorocarbene

Computational Studies of Oxahalocarbene Fragmentation: Convergence of Theory and Experiment

New Kinetics Methodologies Applied to Carbene Fragmentation Reactions

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