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Targeting the β secretase BACE1 for Alzheimer's disease therapy

Lancet neurology, 2014-03, Vol.13 (3), p.319-329

2014

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BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions

The Journal of experimental medicine, 2018-03, Vol.215 (3), p.927-940

2018

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Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

eLife, 2017-06, Vol.6

2017

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Sequential formation of different layers of dystrophic neurites in Alzheimer's brains

Molecular psychiatry, 2019-09, Vol.24 (9), p.1369-1382

2019

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Role of BACE1 in Alzheimer's synaptic function

Translational neurodegeneration, 2017-08, Vol.6 (1), p.23-23, Article 23

2017

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Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells

PloS one, 2016-09, Vol.11 (9), p.e0163072-e0163072

2016

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BACE1 controls synaptic function through modulating release of synaptic vesicles

Molecular psychiatry, 2021-11, Vol.26 (11), p.6394-6410

2021

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Activity of Alzheimer's γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity

Molecular neurodegeneration, 2020-11, Vol.15 (1), p.69-4, Article 69

2020

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Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China

PloS one, 2015-12, Vol.10 (12), p.e0144898-e0144898

2015

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Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains

Molecular neurodegeneration, 2021-07, Vol.16 (1), p.45-45, Article 45

2021

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Reversible Overexpression of Bace1 -Cleaved Neuregulin-1 N -Terminal Fragment Induces Schizophrenia-Like Phenotypes in Mice

Biological psychiatry (1969), 2014-07, Vol.76 (2), p.120-127

2014

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RTN1 and RTN3 protein are differentially associated with senile plaques in Alzheimer's brains

Scientific reports, 2017-07, Vol.7 (1), p.6145-9, Article 6145

2017

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Inhibition of BACE1 in glial cells for enhancing clearance of amyloid plaques

Alzheimer's & dementia, 2023-12, Vol.19 (S24)

Yan, Riqiang

2023

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A Close Look at BACE1 Inhibitors for Alzheimer’s Disease Treatment

CNS drugs, 2019-03, Vol.33 (3), p.251-263

2019

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Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2

Frontiers in molecular neuroscience, 2017-04, Vol.10, p.97-97

Yan, Riqiang

2017

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VPS35 haploinsufficiency increases Alzheimer's disease neuropathology

The Journal of cell biology, 2011-11, Vol.195 (5), p.765-779

2011

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High glucose promotes Aβ production by inhibiting APP degradation

PloS one, 2013-07, Vol.8 (7), p.e69824-e69824

2013

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Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience in Rats

International journal of molecular sciences, 2023-01, Vol.24 (2), p.1206

2023

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BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

Molecular neurodegeneration, 2023-05, Vol.18 (1), p.31-31, Article 31

2023

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Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome

PloS one, 2014-12, Vol.9 (12), p.e114521

2014

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High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling

PloS one, 2013-01, Vol.8 (1), p.e55384

2013

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Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs

Translational neurodegeneration, 2016-07, Vol.5 (1), p.13-13, Article 13

Yan, Riqiang

2016

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BACE1 Regulates Hippocampal Astrogenesis via the Jagged1-Notch Pathway

Cell reports (Cambridge), 2013-07, Vol.4 (1), p.40-49

2013

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Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles

PloS one, 2013-08, Vol.8 (8), p.e70991-e70991

2013

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RCAN1 overexpression exacerbates calcium overloading-induced neuronal apoptosis

PloS one, 2014-04, Vol.9 (4), p.e95471

2014

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Targeting the β secretase BACE1 for Alzheimer's disease therapy

BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions

Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

Sequential formation of different layers of dystrophic neurites in Alzheimer's brains

Role of BACE1 in Alzheimer's synaptic function

Three Dimensional Human Neuro-Spheroid Model of Alzheimer's Disease Based on Differentiated Induced Pluripotent Stem Cells

BACE1 controls synaptic function through modulating release of synaptic vesicles

Activity of Alzheimer's γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity

Polygenic Analysis of Late-Onset Alzheimer's Disease from Mainland China

Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer's disease brains

Reversible Overexpression of Bace1 -Cleaved Neuregulin-1 N -Terminal Fragment Induces Schizophrenia-Like Phenotypes in Mice

RTN1 and RTN3 protein are differentially associated with senile plaques in Alzheimer's brains

Inhibition of BACE1 in glial cells for enhancing clearance of amyloid plaques

A Close Look at BACE1 Inhibitors for Alzheimer’s Disease Treatment

Physiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2

VPS35 haploinsufficiency increases Alzheimer's disease neuropathology

High glucose promotes Aβ production by inhibiting APP degradation

Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience in Rats

BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome

High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling

Stepping closer to treating Alzheimer's disease patients with BACE1 inhibitor drugs

BACE1 Regulates Hippocampal Astrogenesis via the Jagged1-Notch Pathway

Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles

RCAN1 overexpression exacerbates calcium overloading-induced neuronal apoptosis

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