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Population pharmacokinetic/pharmacodynamic modeling and exposure-response analysis of ciprofol in the induction and maintenance of general anesthesia in patients undergoing elective surgery: A prospective dose optimization study
Journal of clinical anesthesia, 2024-02, Vol.92, p.111317-111317, Article 111317
2024
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Safety, pharmacokinetics and pharmacodynamics of a novel γ-aminobutyric acid (GABA) receptor potentiator, HSK3486, in Chinese patients with hepatic impairment
Annals of medicine (Helsinki), 2022-12, Vol.54 (1), p.2757-2768
2022
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Safety, Pharmacokinetics, and Pharmacodynamics of a Single Bolus of the γ-aminobutyric Acid (GABA) Receptor Potentiator HSK3486 in Healthy Chinese Elderly and Non-elderly
Frontiers in pharmacology, 2021-08, Vol.12, p.735700-735700
2021
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Concentration‐QTc Modeling of the DPP‐4 Inhibitor HSK7653 in a First‐in‐Human Study of Chinese Healthy Volunteers
Clinical pharmacology in drug development, 2024-07, Vol.13 (7), p.716-728
2024
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Pharmacokinetics, pharmacodynamics, and safety of ciprofol emulsion in Chinese subjects with normal or impaired renal function
Frontiers in pharmacology, 2023, Vol.14, p.1260599-1260599
2023
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Pharmacokinetics and exposure–safety relationship of ciprofol for sedation in mechanically ventilated patients in the intensive care unit
CPT: pharmacometrics and systems pharmacology, 2024-05, Vol.13 (5), p.823-836
2024
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Mass balance, pharmacokinetics and pharmacodynamics of intravenous HSK3486, a novel anaesthetic, administered to healthy subjects
British journal of clinical pharmacology, 2021-01, Vol.87 (1), p.93-105
2021
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Model informed drug development: HSK21542 PBPK model supporting dose decisions in specific populations
European journal of pharmaceutical sciences, 2024-05, Vol.196, p.106763-106763, Article 106763
2024
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Dose decision of HSK7653 oral immediate release tablets in specific populations clinical trials based on mechanistic physiologically-based pharmacokinetic model
European journal of pharmaceutical sciences, 2023-10, Vol.189, p.106553-106553, Article 106553
2023
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Design, Synthesis, and Evaluation of a Series of Novel Super Long-Acting DPP‑4 Inhibitors for the Treatment of Type 2 Diabetes
Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.7108-7126
2020
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Comparison of the Efficacy of HSK3486 and Propofol for Induction of General Anesthesia in Adults: A Multicenter, Randomized, Double-blind, Controlled, Phase 3 Noninferiority Trial
Anesthesiology (Philadelphia), 2024-04, Vol.140 (4), p.690
2024
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Oral Delivery of Propofol with Methoxymethylphosphonic Acid as the Delivery Vehicle
Journal of medicinal chemistry, 2017-10, Vol.60 (20), p.8580-8590
2017
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Abstract CT128: Phase 1 study of HSK29116, a Bruton tyrosine kinase (BTK) proteolysis-targeting chimera (PROTAC) agent, in patients with relapsed or refractory B-cell malignancies
Cancer research (Chicago, Ill.), 2023-04, Vol.83 (8_Supplement), p.CT128-CT128
2023
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Abstract LB262: HSK38008: An oral AR-V7 degrader for metastatic castration-resistant prostate cancer
Cancer research (Chicago, Ill.), 2023-04, Vol.83 (8_Supplement), p.LB262-LB262
2023
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Abstract C254: Discovery of a novel and potent BRAF (V600E) inhibitor with a unique kinase targeting profile, EBI-907: Pharmacological characterization and potential to overcome drug resistance and paradoxical activation
Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.C254-C254
2013
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The Immunosuppressant Cyclosporin A Antagonizes Human Formyl Peptide Receptor through Inhibition of Cognate Ligand Binding
Journal of Immunology, 2006-11, Vol.177 (10), p.7050-7058
2006
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Oral Delivery of Propofol with Methoxymethyl­phosphonic Acid as the Delivery Vehicle
Journal of medicinal chemistry, 2017-10, Vol.60 (20), p.8580-8590
2017
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