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Phosphatidylinositol 3‐kinase inhibitors: promising drug candidates for cancer therapy

Cancer science, 2008-09, Vol.99 (9), p.1734-1740

2008

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ZSTK474 is an ATP‐competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms

Cancer science, 2007-10, Vol.98 (10), p.1638-1642

2007

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Discovery of Inhibitors of Membrane Traffic from a Panel of Clinically Effective Anticancer Drugs

Biological and Pharmaceutical Bulletin, 2019/05/01, Vol.42(5), pp.814-818

2019

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JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs

Bioorganic & medicinal chemistry, 2012-03, Vol.20 (6), p.1947-1951

2012

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Reforms of regulatory pathways for approval of new antineoplastic drugs in Japan from 2004 to 2019 and accompanying changes in pivotal clinical trial designs

Investigational new drugs, 2022-02, Vol.40 (1), p.142-150

2022

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Advances in development of phosphatidylinositol 3-kinase inhibitors

Current medicinal chemistry, 2009-08, Vol.16 (22), p.2839

2009

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Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting

Science translational medicine, 2011-01, Vol.3 (64), p.64ra2

2011

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Efficacy of RG7787, a next-generation mesothelin-targeted immunotoxin, against triple-negative breast and gastric cancers

Molecular cancer therapeutics, 2014-11, Vol.13 (11), p.2653-2661

2014

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Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor

Cancer science, 2021-05, Vol.112 (5), p.1963-1974

2021

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Antitumor Activity of ZSTK474, a New Phosphatidylinositol 3-Kinase Inhibitor

JNCI : Journal of the National Cancer Institute, 2006-04, Vol.98 (8), p.545-556

2006

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Panel of human cancer cell lines provides valuable database for drug discovery and bioinformatics

Cancer chemotherapy and pharmacology, 2003-07, Vol.52, p.S74-S79

YAMORI, Takao

2003

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Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39

European journal of cancer (1990), 2010-04, Vol.46 (6), p.1111-1121

2010

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Effect of ZSTK474, a Novel Phosphatidylinositol 3-Kinase Inhibitor, on DNA-Dependent Protein Kinase

Biological and Pharmaceutical Bulletin, 2009/02/01, Vol.32(2), pp.297-300

2009

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Telomestatin Impairs Glioma Stem Cell Survival and Growth through the Disruption of Telomeric G-Quadruplex and Inhibition of the Proto-oncogene, c-Myb

Clinical cancer research, 2012-03, Vol.18 (5), p.1268-1280

2012

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A Potential Role of Adhesion Molecules on Lung Metastasis Enhanced by Local Inflammation

Anticancer research, 2020-11, Vol.40 (11), p.6171-6178

2020

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Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells

Scientific reports, 2018-10, Vol.8 (1), p.14827-15, Article 14827

2018

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Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole

Scientific reports, 2017-06, Vol.7 (1), p.3605-11, Article 3605

2017

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Pyrrocidine A, a metabolite of endophytic fungi, has a potent apoptosis-inducing activity against HL60 cells through caspase activation via the Michael addition

Journal of antibiotics, 2016-03, Vol.69 (3), p.133-140

2016

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ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor identified using the JFCR39 drug discovery system

Acta pharmacologica Sinica, 2010-09, Vol.31 (9), p.1189-1197

2010

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Autotaxin Has Lysophospholipase D Activity Leading to Tumor Cell Growth and Motility by Lysophosphatidic Acid Production

The Journal of cell biology, 2002-07, Vol.158 (2), p.227-233

2002

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Yaku’amides A and B, Cytotoxic Linear Peptides Rich in Dehydroamino Acids from the Marine Sponge Ceratopsion sp

Journal of the American Chemical Society, 2010-12, Vol.132 (50), p.17692-17694

2010

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M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (13), p.3895-3903

2016

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Isolation and structures of biselyngbyasides B, C, and D from the marine cyanobacterium Lyngbya sp., and the biological activities of biselyngbyasides

Tetrahedron, 2012-07, Vol.68 (30), p.5984-5990

2012

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G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor

Proceedings of the National Academy of Sciences - PNAS, 2010-10, Vol.107 (40), p.17309-17314

2010

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Search for Novel Anti-tumor Agents from Ridaifens Using JFCR39, a Panel of Human Cancer Cell Lines

Biological and Pharmaceutical Bulletin, 2013/06/01, Vol.36(6), pp.1008-1016

2013

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Phosphatidylinositol 3‐kinase inhibitors: promising drug candidates for cancer therapy

ZSTK474 is an ATP‐competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms

Discovery of Inhibitors of Membrane Traffic from a Panel of Clinically Effective Anticancer Drugs

JFCR39, a panel of 39 human cancer cell lines, and its application in the discovery and development of anticancer drugs

Reforms of regulatory pathways for approval of new antineoplastic drugs in Japan from 2004 to 2019 and accompanying changes in pivotal clinical trial designs

Advances in development of phosphatidylinositol 3-kinase inhibitors

Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting

Efficacy of RG7787, a next-generation mesothelin-targeted immunotoxin, against triple-negative breast and gastric cancers

Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor

Antitumor Activity of ZSTK474, a New Phosphatidylinositol 3-Kinase Inhibitor

Panel of human cancer cell lines provides valuable database for drug discovery and bioinformatics

Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39

Effect of ZSTK474, a Novel Phosphatidylinositol 3-Kinase Inhibitor, on DNA-Dependent Protein Kinase

Telomestatin Impairs Glioma Stem Cell Survival and Growth through the Disruption of Telomeric G-Quadruplex and Inhibition of the Proto-oncogene, c-Myb

A Potential Role of Adhesion Molecules on Lung Metastasis Enhanced by Local Inflammation

Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells

Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocyclic hexaoxazole

Pyrrocidine A, a metabolite of endophytic fungi, has a potent apoptosis-inducing activity against HL60 cells through caspase activation via the Michael addition

ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor identified using the JFCR39 drug discovery system

Autotaxin Has Lysophospholipase D Activity Leading to Tumor Cell Growth and Motility by Lysophosphatidic Acid Production

Yaku’amides A and B, Cytotoxic Linear Peptides Rich in Dehydroamino Acids from the Marine Sponge Ceratopsion sp

M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers

Isolation and structures of biselyngbyasides B, C, and D from the marine cyanobacterium Lyngbya sp., and the biological activities of biselyngbyasides

G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor

Search for Novel Anti-tumor Agents from Ridaifens Using JFCR39, a Panel of Human Cancer Cell Lines

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