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Targeting a Binding Pocket within the Trimer-of-Hairpins: Small-Molecule Inhibition of Viral Fusion

Proceedings of the National Academy of Sciences - PNAS, 2004-10, Vol.101 (42), p.15046-15051

2004

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Orally Active Fusion Inhibitor of Respiratory Syncytial Virus

Antimicrobial Agents and Chemotherapy, 2004-02, Vol.48 (2), p.413-422

2004

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Oral Efficacy of a Respiratory Syncytial Virus Inhibitor in Rodent Models of Infection

Antimicrobial Agents and Chemotherapy, 2004-07, Vol.48 (7), p.2448-2454

2004

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Respiratory syncytial virus fusion inhibitors. Part 7: Structure–activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4857-4862

2009

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Novel 3-Aryl Indoles as Progesterone Receptor Antagonists for Uterine Fibroids

ACS medicinal chemistry letters, 2011-02, Vol.2 (2), p.148-153

2011

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Respiratory syncytial virus fusion inhibitors. Part 4: Optimization for oral bioavailability

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (4), p.895-901

2007

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pH-Dependent Changes in Photoaffinity Labeling Patterns of the H1 Influenza Virus Hemagglutinin by Using an Inhibitor of Viral Fusion

Journal of Virology, 1999-03, Vol.73 (3), p.1785-1794

1999

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Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity

Bioorganic & medicinal chemistry letters, 2007-08, Vol.17 (16), p.4592-4598

2007

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Respiratory syncytial virus fusion inhibitors. Part 6: An examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety

Bioorganic & medicinal chemistry letters, 2007-09, Vol.17 (17), p.4784-4790

2007

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Serine 232 and Methionine 272 Define the Ligand Binding Pocket in Retinoic Acid Receptor Subtypes

The Journal of biological chemistry, 1998-02, Vol.273 (6), p.3490-3495

1998

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Infrared and Nuclear Magnetic Resonance Spectroscopic Study of Secondary Amide Hydrogen Bonding in Benzoyl PABA Derivatives (Retinoids)

Applied spectroscopy, 2007-06, Vol.61 (6), p.603-607

2007

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Fundamental structure–Activity relationships associated with a new structural class of respiratory syncytial virus inhibitor

Bioorganic & medicinal chemistry letters, 2003-07, Vol.13 (13), p.2141-2144

2003

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Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (5), p.1115-1122

2006

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Structure–activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-Trimethyl-5-hydroxy-cyclohexylmethylamine

Bioorganic & medicinal chemistry letters, 2002-12, Vol.12 (23), p.3379-3382

2002

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A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor

The Journal of biological chemistry, 2003-01, Vol.278 (4), p.2403

2003

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Development of a photoaffinity label for respiratory syncytial virus inhibitors

Journal of labelled compounds & radiopharmaceuticals, 2003-10, Vol.46 (12), p.1105-1116

2003

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Heck reactions in solid phase synthesis

Tetrahedron letters, 1994-11, Vol.35 (48), p.8919-8922

1994

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Application of the Heck reaction in the synthesis of truncated naphthoic acid retinoids

Bioorganic & medicinal chemistry letters, 1996-12, Vol.6 (23), p.2859-2864

1996

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Corrigendum to “Respiratory syncytial virus fusion inhibitors. Part 4: Optimization for oral bioavailability” [Bioorg. Med. Chem. Lett. 17 (2007) 895–901]

Bioorganic & medicinal chemistry letters, 2007-04, Vol.17 (8), p.2385-2385

2007

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Synthesis and chemical properties of tetrazole peptide analogs

Journal of organic chemistry, 1987-05, Vol.52 (10), p.2051-2059

1987

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Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1133-1137

2004

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Dopamine receptor modulation by conformationally constrained analogs of Pro-Leu-Gly-NH2

Journal of medicinal chemistry, 1988-07, Vol.31 (7), p.1430-1436

1988

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Abstract 1961: Discovery of a highly potent and brain penetrant fourth generation EGFR tyrosine kinase inhibitor

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.1961-1961

2024

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Abstract 1968: Discovery of a highly potent and selective FGFR2 inhibitor for FGFR2-driven cancers

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.1968-1968

2024

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Abstract 5947: Discovery of ACE-47228211, a highly potent and selective SOS1 inhibitor

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.5947-5947

2024

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Targeting a Binding Pocket within the Trimer-of-Hairpins: Small-Molecule Inhibition of Viral Fusion

Orally Active Fusion Inhibitor of Respiratory Syncytial Virus

Oral Efficacy of a Respiratory Syncytial Virus Inhibitor in Rodent Models of Infection

Respiratory syncytial virus fusion inhibitors. Part 7: Structure–activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo

Novel 3-Aryl Indoles as Progesterone Receptor Antagonists for Uterine Fibroids

Respiratory syncytial virus fusion inhibitors. Part 4: Optimization for oral bioavailability

pH-Dependent Changes in Photoaffinity Labeling Patterns of the H1 Influenza Virus Hemagglutinin by Using an Inhibitor of Viral Fusion

Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity

Respiratory syncytial virus fusion inhibitors. Part 6: An examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety

Serine 232 and Methionine 272 Define the Ligand Binding Pocket in Retinoic Acid Receptor Subtypes

Infrared and Nuclear Magnetic Resonance Spectroscopic Study of Secondary Amide Hydrogen Bonding in Benzoyl PABA Derivatives (Retinoids)

Fundamental structure–Activity relationships associated with a new structural class of respiratory syncytial virus inhibitor

Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo

Structure–activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-Trimethyl-5-hydroxy-cyclohexylmethylamine

A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor

Development of a photoaffinity label for respiratory syncytial virus inhibitors

Heck reactions in solid phase synthesis

Application of the Heck reaction in the synthesis of truncated naphthoic acid retinoids

Corrigendum to “Respiratory syncytial virus fusion inhibitors. Part 4: Optimization for oral bioavailability” [Bioorg. Med. Chem. Lett. 17 (2007) 895–901]

Synthesis and chemical properties of tetrazole peptide analogs

Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives

Dopamine receptor modulation by conformationally constrained analogs of Pro-Leu-Gly-NH2

Abstract 1961: Discovery of a highly potent and brain penetrant fourth generation EGFR tyrosine kinase inhibitor

Abstract 1968: Discovery of a highly potent and selective FGFR2 inhibitor for FGFR2-driven cancers

Abstract 5947: Discovery of ACE-47228211, a highly potent and selective SOS1 inhibitor

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