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The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure

Bioorganic & medicinal chemistry, 2020-12, Vol.28 (23), p.115791, Article 115791

2020

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Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]‑1H‑benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)

Journal of medicinal chemistry, 2015-05, Vol.58 (9), p.3859-3874

2015

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Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists

Bioorganic & medicinal chemistry letters, 2013-04, Vol.23 (7), p.2234-2237

2013

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The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists

Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (8), p.2922-2926

2012

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Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1

Bioorganic & medicinal chemistry, 2007-11, Vol.17 (22), p.6160-6163

2007

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Mannich reactions of resin-bound substrates: 2. A versatile three-component solid-phase organic synthesis methodology

Tetrahedron letters, 1998-02, Vol.39 (9), p.967-970

1998

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N-Isoquinolin-5-yl- N′-aralkyl-urea and -amide antagonists of human vanilloid receptor 1

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3053-3056

2004

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Novel non-peptidic neuropeptide Y Y2 receptor antagonists

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1239-1242

2004

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α-Substituted N-(Sulfonamido)alkyl-β-aminotetralins: Potent and Selective Neuropeptide Y Y5 Receptor Antagonists

Journal of medicinal chemistry, 2000-02, Vol.43 (3), p.346-350

2000

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Design and synthesis of novel pyrrolidine-containing bradykinin antagonists

Bioorganic & medicinal chemistry letters, 2003-06, Vol.13 (11), p.1879-1882

2003

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Enantioselective Diels-Alder reactions: room temperature bis(oxazoline)-zinc, -magnesium, and -copper triflate catalysts

Tetrahedron: asymmetry, 1997-09, Vol.8 (18), p.3073-3078

1997

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N-Acylated α-(3-pyridylmethyl)-β-aminotetralin antagonists of the human neuropeptide Y Y5 receptor

Bioorganic & medicinal chemistry letters, 2000-08, Vol.10 (15), p.1641-1643

2000

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Synthesis and structure–Activity relationships of aroylpyrrole alkylamide bradykinin (B 2) antagonists

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1341-1344

2003

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Multi-component methodologies in solid-phase organic synthesis

Current medicinal chemistry, 1999-03, Vol.6 (3), p.255-270

1999

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Benzo[ d ]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans -2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1 H -benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)

Journal of medicinal chemistry, 2015-05, Vol.58 (9), p.3859-3874

2015

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Mannich Reactions of a Resin-Bound Terminal Alkyne

Tetrahedron letters, 1997-09, Vol.38 (36), p.6347-6350

1997

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Corrigendum to “ N-Pyridin-3-yl- and N-quinolin-3-yl-benzamides: Modulators of Human Vanilloid Receptor 1 (TRPV1)” [Bioorg. Med. Chem. Lett. 18 (2008) 2730–2734]

Bioorganic & medicinal chemistry letters, 2008-07, Vol.18 (14), p.4254-4254

2008

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N-(sulfonamido)alkyl[tetrahydro-1H-benzo[e]indol-2-yl]amines : Potent antagonists of human neuropeptide Y Y5 receptor

Bioorganic & medicinal chemistry letters, 2000-02, Vol.10 (3), p.213-216

2000

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The Synthesis of Novel cis-α-Substituted-β-aminotetralins

Synthetic communications, 2003-01, Vol.33 (13), p.2215-2227

2003

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Novel non-peptidic neuropeptide Y Y 2 receptor antagonists

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1239-1242

2004

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Solid‐Phase Mannich Reactions of a Resin‐Immobilized Alkyne

Solid‐Phase Organic Syntheses, 2001, p.45-53

2001

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The Synthesis of Novel cis-α-Substituted-β-aminotetralins

ChemInform, 2003-10, Vol.34 (42), p.no-no

2003

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ChemInform Abstract: Multi-Component Methodologies in Solid-Phase Organic Synthesis

ChemInform, 1999-06, Vol.30 (24), p.no-no

1999

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N-Isoquinolin-5-yl-N′-aralkyl-urea and -amide Antagonists of Human Vanilloid Receptor 1

ChemInform, 2004-10, Vol.35 (41), p.no-no

2004

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Design and Synthesis of Novel Pyrrolidine-Containing Bradykinin Antagonists

ChemInform, 2003-09, Vol.34 (36), p.no-no

2003

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The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure

Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]‑1H‑benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)

Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists

The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists

Heteroaryl β-tetralin ureas as novel antagonists of human TRPV1

Mannich reactions of resin-bound substrates: 2. A versatile three-component solid-phase organic synthesis methodology

N-Isoquinolin-5-yl- N′-aralkyl-urea and -amide antagonists of human vanilloid receptor 1

Novel non-peptidic neuropeptide Y Y2 receptor antagonists

α-Substituted N-(Sulfonamido)alkyl-β-aminotetralins: Potent and Selective Neuropeptide Y Y5 Receptor Antagonists

Design and synthesis of novel pyrrolidine-containing bradykinin antagonists

Enantioselective Diels-Alder reactions: room temperature bis(oxazoline)-zinc, -magnesium, and -copper triflate catalysts

N-Acylated α-(3-pyridylmethyl)-β-aminotetralin antagonists of the human neuropeptide Y Y5 receptor

Synthesis and structure–Activity relationships of aroylpyrrole alkylamide bradykinin (B 2) antagonists

Multi-component methodologies in solid-phase organic synthesis

Benzo[ d ]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans -2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1 H -benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep)

Mannich Reactions of a Resin-Bound Terminal Alkyne

Corrigendum to “ N-Pyridin-3-yl- and N-quinolin-3-yl-benzamides: Modulators of Human Vanilloid Receptor 1 (TRPV1)” [Bioorg. Med. Chem. Lett. 18 (2008) 2730–2734]

N-(sulfonamido)alkyl[tetrahydro-1H-benzo[e]indol-2-yl]amines : Potent antagonists of human neuropeptide Y Y5 receptor

The Synthesis of Novel cis-α-Substituted-β-aminotetralins

Novel non-peptidic neuropeptide Y Y 2 receptor antagonists

Solid‐Phase Mannich Reactions of a Resin‐Immobilized Alkyne

The Synthesis of Novel cis-α-Substituted-β-aminotetralins

ChemInform Abstract: Multi-Component Methodologies in Solid-Phase Organic Synthesis

N-Isoquinolin-5-yl-N′-aralkyl-urea and -amide Antagonists of Human Vanilloid Receptor 1

Design and Synthesis of Novel Pyrrolidine-Containing Bradykinin Antagonists

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