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The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

Medicinal research reviews, 2016-09, Vol.36 (5), p.924-963

2016

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Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions

Journal of medicinal chemistry, 2020-03, Vol.63 (5), p.1798-1822

2020

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Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications

Free radical biology & medicine, 2021-05, Vol.168, p.129-141

2021

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Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions

Journal of medicinal chemistry, 2016-12, Vol.59 (24), p.10837-10858

2016

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5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress

Free radical biology & medicine, 2019-04, Vol.134, p.288-303

2019

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Wogonin prevents lipopolysaccharide‐induced acute lung injury and inflammation in mice via peroxisome proliferator‐activated receptor gamma‐mediated attenuation of the nuclear factor‐kappaB pathway

Immunology, 2014-10, Vol.143 (2), p.241-257

2014

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CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation

Redox biology, 2019-09, Vol.26, p.101266-101266, Article 101266

2019

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An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis

Scientific reports, 2016-05, Vol.6 (1), p.26585-26585, Article 26585

2016

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Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions

European journal of medicinal chemistry, 2020-12, Vol.207, p.112734, Article 112734

2020

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Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway

Molecular carcinogenesis, 2014-02, Vol.53 (S1), p.E107-E118

2014

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Wogonin suppresses melanoma cell B16-F10 invasion and migration by inhibiting Ras-medicated pathways

PloS one, 2014-09, Vol.9 (9), p.e106458

2014

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Structure–Activity and Structure–Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1–Nrf2 Protein–Protein Interaction Inhibitor

Journal of medicinal chemistry, 2015-08, Vol.58 (16), p.6410-6421

2015

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Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective

Journal of medicinal chemistry, 2020-04, Vol.63 (8), p.3785-3816

2020

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Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells

Biochemical and biophysical research communications, 2007-09, Vol.361 (1), p.79-84

2007

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Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner

PloS one, 2012-12, Vol.7 (12), p.e50811-e50811

2012

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Wogonin suppresses human alveolar adenocarcinoma cell A549 migration in inflammatory microenvironment by modulating the IL-6/STAT3 signaling pathway

Molecular carcinogenesis, 2015-06, Vol.54 (S1), p.E81-E93

2015

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Isolation and characterization of cancer stem like cells in human glioblastoma cell lines

Cancer letters, 2009-06, Vol.279 (1), p.13-21

2009

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Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation

PloS one, 2013-09, Vol.8 (9), p.e75076-e75076

2013

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Oroxylin a prevents inflammation-related tumor through down-regulation of inflammatory gene expression by inhibiting NF-κB signaling

Molecular carcinogenesis, 2014-02, Vol.53 (2), p.145-158

2014

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Gambogic Acid Inhibits Proliferation of Human Lung Carcinoma SPC-A1 Cells in Vivo and in Vitro and Represses Telomerase Activity and Telomerase Reverse Transcriptase mRNA Expression in the Cells

Biological and Pharmaceutical Bulletin, 2004, Vol.27(11), pp.1769-1774

2004

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Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP

Journal of cellular biochemistry, 2011-02, Vol.112 (2), p.509-519

2011

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Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes

Cancer letters, 2007-10, Vol.256 (2), p.259-266

2007

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Binding thermodynamics and kinetics guided optimization of potent Keap1–Nrf2 peptide inhibitors

RSC advances, 2015, Vol.5 (105), p.85983-85987

2015

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Targeting Hsp90-Cdc37: A Promising Therapeutic Strategy by Inhibiting Hsp90 Chaperone Function

Current drug targets, 2017-01, Vol.18 (13), p.1572

2017

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Gambogic Acid Induces Apoptosis and Regulates Expressions of Bax and Bcl-2 Protein in Human Gastric Carcinoma MGC-803 Cells

Biological and Pharmaceutical Bulletin, 2004, Vol.27(7), pp.998-1003

2004

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The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

Heat Shock Protein 90 Inhibitors: An Update on Achievements, Challenges, and Future Directions

Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications

Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions

5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress

Wogonin prevents lipopolysaccharide‐induced acute lung injury and inflammation in mice via peroxisome proliferator‐activated receptor gamma‐mediated attenuation of the nuclear factor‐kappaB pathway

CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation

An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis

Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions

Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway

Wogonin suppresses melanoma cell B16-F10 invasion and migration by inhibiting Ras-medicated pathways

Structure–Activity and Structure–Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1–Nrf2 Protein–Protein Interaction Inhibitor

Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective

Endostar, a novel recombinant human endostatin, exerts antiangiogenic effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells

Wogonin induced calreticulin/annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner

Wogonin suppresses human alveolar adenocarcinoma cell A549 migration in inflammatory microenvironment by modulating the IL-6/STAT3 signaling pathway

Isolation and characterization of cancer stem like cells in human glioblastoma cell lines

Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation

Oroxylin a prevents inflammation-related tumor through down-regulation of inflammatory gene expression by inhibiting NF-κB signaling

Gambogic Acid Inhibits Proliferation of Human Lung Carcinoma SPC-A1 Cells in Vivo and in Vitro and Represses Telomerase Activity and Telomerase Reverse Transcriptase mRNA Expression in the Cells

Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP

Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes

Binding thermodynamics and kinetics guided optimization of potent Keap1–Nrf2 peptide inhibitors

Targeting Hsp90-Cdc37: A Promising Therapeutic Strategy by Inhibiting Hsp90 Chaperone Function

Gambogic Acid Induces Apoptosis and Regulates Expressions of Bax and Bcl-2 Protein in Human Gastric Carcinoma MGC-803 Cells

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