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Activated type I TGFβ receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

Oncogene, 2006-06, Vol.25 (24), p.3408-3423

2006

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Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

Molecular and Cellular Biology, 1997-12, Vol.17 (12), p.7019-7028

1997

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Mammalian Dwarfins are Phosphorylated in Response to Transforming Growth Factor β and are Implicated in Control of Cell Growth

Proceedings of the National Academy of Sciences - PNAS, 1996-08, Vol.93 (17), p.8940-8944

1996

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Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development

Development (Cambridge), 1999-09, Vol.126 (18), p.4005-4015

1999

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Development and validation of a phosphorylated SMAD ex vivo stimulation assay

Biomarkers, 2007-05, Vol.12 (3), p.313-330

2007

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Epithelial/mesenchymal interactions and branching morphogenesis of the lung

Current opinion in genetics & development, 1998-08, Vol.8 (4), p.481-486

1998

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An estrogen receptor positive MCF-7 clone that is resistant to antiestrogens and estradiol

Molecular and cellular endocrinology, 1992-12, Vol.90 (1), p.77-86

1992

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Dihydropyrrolopyrazole Transforming Growth Factor-β Type I Receptor Kinase Domain Inhibitors: A Novel Benzimidazole Series with Selectivity versus Transforming Growth Factor-β Type II Receptor Kinase and Mixed Lineage Kinase-7

Journal of medicinal chemistry, 2006-03, Vol.49 (6), p.2138-2142

2006

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Smad5 induces ventral fates in Xenopus embryo

Developmental biology, 1997-04, Vol.184 (2), p.402-405

1997

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Development of TGF-β signalling inhibitors for cancer therapy

Nature reviews. Drug discovery, 2004-12, Vol.3 (12), p.1011-1022

2004

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A Transforming Growth Factor β Type I Receptor That Signals to Activate Gene Expression

Science (American Association for the Advancement of Science), 1994-01, Vol.263 (5143), p.87-89

1994

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Reduced SMAD7 Leads to Overactivation of TGF-β Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-β Receptor I Kinase

Cancer research (Chicago, Ill.), 2011-02, Vol.71 (3), p.955-963

2011

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Pilon Fractures: Challenges and Solutions

Orthopedic research and reviews, 2019-09, Vol.11, p.149-157

2019

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Signaling by the transforming growth factor-beta receptors

Biochimica et biophysica acta, 1995-12, Vol.1242 (2), p.115

1995

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Receptors for the TGF-β Ligand Family

Vitamins and Hormones, 1994, Vol.48, p.111-156

1994

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Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (13), p.3581-3584

2004

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Smad7 Regulates the Adult Neural Stem/Progenitor Cell Pool in a Transforming Growth Factor β- and Bone Morphogenetic Protein-Independent Manner

Molecular and Cellular Biology, 2010-07, Vol.30 (14), p.3685-3694

2010

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Kinetic Characterization of Novel Pyrazole TGF-β Receptor I Kinase Inhibitors and Their Blockade of the Epithelial−Mesenchymal Transition

Biochemistry (Easton), 2005-02, Vol.44 (7), p.2293-2304

2005

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Activated type I TGFb receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

Oncogene, 2006-06, Vol.25 (24), p.3408-3423

2006

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Activated type I TGF receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

Oncogene, 2006-06, Vol.25 (24), p.3408-3423

2006

Volltextzugriff (PDF)

Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

Oncogene, 2006-06, Vol.25 (24), p.3408-3423

2006

Volltextzugriff (PDF)

Novel and potent transforming growth factor beta type I receptor kinase domain inhibitor: 7-amino 4-(2-pyridin-2-yl-5,6-dihydro-4 H-pyrrolo[1,2- b]pyrazol-3-yl)-quinolines

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (13), p.3585-3588

2004

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Antiproliferative effects of interferons -α and -β in combination with 5-fluorouracil, cisplatin, and cis- and trans-retinoic acid in three human lung carcinoma cell lines

Journal of interferon research, 1993-02, Vol.13 (1), p.25-32

1993

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TGF Blockade as Anticancer Therapy

AACR education book, 2008-04, Vol.2008 (1), p.71-81

2008

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A transforming growth factor β type I receptor that signals to active gene expression

Science (American Association for the Advancement of Science), 1994, Vol.263 (5143), p.87-89

1994

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Activated type I TGFβ receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

Mammalian Dwarfins are Phosphorylated in Response to Transforming Growth Factor β and are Implicated in Control of Cell Growth

Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development

Development and validation of a phosphorylated SMAD ex vivo stimulation assay

Epithelial/mesenchymal interactions and branching morphogenesis of the lung

An estrogen receptor positive MCF-7 clone that is resistant to antiestrogens and estradiol

Dihydropyrrolopyrazole Transforming Growth Factor-β Type I Receptor Kinase Domain Inhibitors: A Novel Benzimidazole Series with Selectivity versus Transforming Growth Factor-β Type II Receptor Kinase and Mixed Lineage Kinase-7

Smad5 induces ventral fates in Xenopus embryo

Development of TGF-β signalling inhibitors for cancer therapy

A Transforming Growth Factor β Type I Receptor That Signals to Activate Gene Expression

Reduced SMAD7 Leads to Overactivation of TGF-β Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-β Receptor I Kinase

Pilon Fractures: Challenges and Solutions

Signaling by the transforming growth factor-beta receptors

Receptors for the TGF-β Ligand Family

Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain

Smad7 Regulates the Adult Neural Stem/Progenitor Cell Pool in a Transforming Growth Factor β- and Bone Morphogenetic Protein-Independent Manner

Kinetic Characterization of Novel Pyrazole TGF-β Receptor I Kinase Inhibitors and Their Blockade of the Epithelial−Mesenchymal Transition

Activated type I TGFb receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

Activated type I TGF receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

Novel and potent transforming growth factor beta type I receptor kinase domain inhibitor: 7-amino 4-(2-pyridin-2-yl-5,6-dihydro-4 H-pyrrolo[1,2- b]pyrazol-3-yl)-quinolines

Antiproliferative effects of interferons -α and -β in combination with 5-fluorouracil, cisplatin, and cis- and trans-retinoic acid in three human lung carcinoma cell lines

TGF Blockade as Anticancer Therapy

A transforming growth factor β type I receptor that signals to active gene expression

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