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Therapeutic Synergy Between Irinotecan and 5-Fluorouracil against Human Tumor Xenografts

Clinical cancer research, 2004-02, Vol.10 (3), p.1121-1129

2004

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Downregulation of Cystine Transporter xc– by Irinotecan in Human Head and Neck Cancer FaDu Xenografts

Chemotherapy (Basel), 2010, Vol.56 (3), p.223-233

2010

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Induction of Biphasic DNA Double Strand Breaks and Activation of Multiple Repair Protein Complexes by DNA Topoisomerase I Drug 7-Ethyl-10-hydroxy-camptothecin

Molecular pharmacology, 2002-04, Vol.61 (4), p.742-748

2002

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Enhanced 7-Ethyl-10-hydroxycamptothecin (SN-38) Lethality by Methylselenocysteine Is Associated with Chk2 Phosphorylation at Threonine-68 and Down-Regulation of Cdc6 Expression

Molecular pharmacology, 2004-07, Vol.66 (1), p.153-160

2004

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The Chk1-Cdc25C regulation is involved in sensitizing A253 cells to a novel topoisomerase I inhibitor BNP1350 by bax gene transfer

Oncogene, 2001-08, Vol.20 (38), p.5249-5257

2001

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Targeting molecular signals in chk1 pathways as a new approach for overcoming drug resistance

Cancer and metastasis reviews, 2001-01, Vol.20 (1-2), p.109-115

2001

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Characterization of Protein Kinase chk1 Essential for the Cell Cycle Checkpoint after Exposure of Human Head and Neck Carcinoma A253 Cells to a Novel Topoisomerase I Inhibitor BNP1350

Molecular pharmacology, 2000-03, Vol.57 (3), p.453-459

2000

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Involvement of cyclin d1‐cdk5 overexpression and mcm3 cleavage in bax‐associated spontaneous apoptosis and differentiation in an a253 human head and neck carcinoma xenograft model

International journal of cancer, 1999-10, Vol.83 (3), p.341-348

1999

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Mechanisms of resistance to N-[5-[ N-(3, 4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)- N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line

Biochemical pharmacology, 1995-07, Vol.50 (3), p.391-398

1995

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p53 and WAF1 Are Induced and Rb Protein Is Hypophosphorylated during Cell Growth Inhibition by the Thymidylate Synthase Inhibitor ZD1694 (Tomudex)

Molecular pharmacology, 1997-04, Vol.51 (4), p.630-636

1997

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Chk1 signaling pathways that mediated G2M checkpoint in relation to the cellular resistance to the novel topoisomerase I poison BNP1350

Biochemical and biophysical research communications, 2002-07, Vol.295 (2), p.435-444

2002

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Time dependence of DNA lesions and growth inhibition by ICI D1694, a new quinazoline antifolate thymidylate synthase inhibitor

Cancer research (Chicago, Ill.), 1992-11, Vol.52 (21), p.5900-5905

1992

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Contrasting patterns of DNA fragmentation induced by thymidylate synthase inhibitors, ZD1694 and AG-331

Oncology research, 1995, Vol.7 (2), p.73

1995

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Carbamoylation of glutathione reductase by n,n-bis(2-chloroethyl)- n-nitrosourea associated with inhibition of multidrug resistance protein (MRP) function

Biochemical pharmacology, 1997-03, Vol.53 (6), p.801-809

1997

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Mechanisms of the in vivo resistance to adriamycin and modulation by calcium channel blockers in mice

Cancer research (Chicago, Ill.), 1989-09, Vol.49 (17), p.4729-4733

1989

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Cyclin E–Cdk2 Activation Is Associated with Cell Cycle Arrest and Inhibition of DNA Replication Induced by the Thymidylate Synthase Inhibitor Tomudex

Experimental cell research, 1999-02, Vol.247 (1), p.189-199

1999

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Phosphorylation of chk1 at serine-345 affected by topoisomerase I poison SN-38

International journal of oncology, 2002-11, Vol.21 (5), p.1059

2002

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Down-regulation of c-myc gene expression with induction of high molecular weight DNA fragments by fluorodeoxyuridine

Biochemical pharmacology, 1994-07, Vol.48 (2), p.327-334

1994

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Relationship between cytotoxicity, drug accumulation, DNA damage and repair of human ovarian cancer cells treated with doxorubicin: modulation by the tiapamil analog RO11-2933

Cancer chemotherapy and pharmacology, 1989, Vol.25 (2), p.77-83

1989

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Dimerization of mitochondrial Bax is associated with increased drug response in Bax-transfected A253 cells

Oncology research, 1999, Vol.11 (2), p.91

1999

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Cellular heterogeneity in DNA damage and growth inhibition induced by ICI D1694, thymidylate synthase inhibitor, using single cell assays

Biochemical pharmacology, 1994-08, Vol.48 (5), p.997-1002

1994

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Novel cellular determinants for reversal of multidrug resistance in cells expressing P170-glycoprotein

Biochimica et biophysica acta, 1998-03, Vol.1401 (3), p.265-276

1998

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DiOC2(3) is not a substrate for multidrug resistance protein (MRP)‐mediated drug efflux

Cytometry (New York, N.Y.), 1996-09, Vol.25 (1), p.14-20

1996

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Recent advances in the study of rTS proteins. rTS expression during growth and in response to thymidylate synthase inhibitors in human tumor cells

Advances in enzyme regulation, 1997, Vol.37, p.95-109

1997

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Targeting molecular signals in chk1 pathways as a new approach for overcoming drug resistance: Molecular and Physiologic Mechanisms of Drug Resistance in Cancer

Cancer and metastasis reviews, 2001, Vol.20 (1-2), p.109-115

2001

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Therapeutic Synergy Between Irinotecan and 5-Fluorouracil against Human Tumor Xenografts

Downregulation of Cystine Transporter xc– by Irinotecan in Human Head and Neck Cancer FaDu Xenografts

Induction of Biphasic DNA Double Strand Breaks and Activation of Multiple Repair Protein Complexes by DNA Topoisomerase I Drug 7-Ethyl-10-hydroxy-camptothecin

Enhanced 7-Ethyl-10-hydroxycamptothecin (SN-38) Lethality by Methylselenocysteine Is Associated with Chk2 Phosphorylation at Threonine-68 and Down-Regulation of Cdc6 Expression

The Chk1-Cdc25C regulation is involved in sensitizing A253 cells to a novel topoisomerase I inhibitor BNP1350 by bax gene transfer

Targeting molecular signals in chk1 pathways as a new approach for overcoming drug resistance

Characterization of Protein Kinase chk1 Essential for the Cell Cycle Checkpoint after Exposure of Human Head and Neck Carcinoma A253 Cells to a Novel Topoisomerase I Inhibitor BNP1350

Involvement of cyclin d1‐cdk5 overexpression and mcm3 cleavage in bax‐associated spontaneous apoptosis and differentiation in an a253 human head and neck carcinoma xenograft model

Mechanisms of resistance to N-[5-[ N-(3, 4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)- N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line

p53 and WAF1 Are Induced and Rb Protein Is Hypophosphorylated during Cell Growth Inhibition by the Thymidylate Synthase Inhibitor ZD1694 (Tomudex)

Chk1 signaling pathways that mediated G2M checkpoint in relation to the cellular resistance to the novel topoisomerase I poison BNP1350

Time dependence of DNA lesions and growth inhibition by ICI D1694, a new quinazoline antifolate thymidylate synthase inhibitor

Contrasting patterns of DNA fragmentation induced by thymidylate synthase inhibitors, ZD1694 and AG-331

Carbamoylation of glutathione reductase by n,n-bis(2-chloroethyl)- n-nitrosourea associated with inhibition of multidrug resistance protein (MRP) function

Mechanisms of the in vivo resistance to adriamycin and modulation by calcium channel blockers in mice

Cyclin E–Cdk2 Activation Is Associated with Cell Cycle Arrest and Inhibition of DNA Replication Induced by the Thymidylate Synthase Inhibitor Tomudex

Phosphorylation of chk1 at serine-345 affected by topoisomerase I poison SN-38

Down-regulation of c-myc gene expression with induction of high molecular weight DNA fragments by fluorodeoxyuridine

Relationship between cytotoxicity, drug accumulation, DNA damage and repair of human ovarian cancer cells treated with doxorubicin: modulation by the tiapamil analog RO11-2933

Dimerization of mitochondrial Bax is associated with increased drug response in Bax-transfected A253 cells

Cellular heterogeneity in DNA damage and growth inhibition induced by ICI D1694, thymidylate synthase inhibitor, using single cell assays

Novel cellular determinants for reversal of multidrug resistance in cells expressing P170-glycoprotein

DiOC2(3) is not a substrate for multidrug resistance protein (MRP)‐mediated drug efflux

Recent advances in the study of rTS proteins. rTS expression during growth and in response to thymidylate synthase inhibitors in human tumor cells

Targeting molecular signals in chk1 pathways as a new approach for overcoming drug resistance: Molecular and Physiologic Mechanisms of Drug Resistance in Cancer

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