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Dapagliflozin and Ticagrelor Have Additive Effects on the Attenuation of the Activation of the NLRP3 Inflammasome and the Progression of Diabetic Cardiomyopathy: an AMPK–mTOR Interplay

Cardiovascular drugs and therapy, 2020-08, Vol.34 (4), p.443-461

2020

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Deriving functional human enteroendocrine cells from pluripotent stem cells

Development (Cambridge), 2018-10, Vol.145 (19)

2018

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Differential In Vitro Effects of SGLT2 Inhibitors on Mitochondrial Oxidative Phosphorylation, Glucose Uptake and Cell Metabolism

International journal of molecular sciences, 2022-07, Vol.23 (14), p.7966

2022

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Structural basis for GPR40 allosteric agonism and incretin stimulation

Nature communications, 2018-04, Vol.9 (1), p.1645-11, Article 1645

2018

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SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes. Further Augmentation of the Effects with Saxagliptin, a DPP4 Inhibitor

Cardiovascular drugs and therapy, 2017-04, Vol.31 (2), p.119-132

2017

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Combined SGLT2 and DPP4 Inhibition Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Nephropathy in Mice with Type 2 Diabetes

Cardiovascular drugs and therapy, 2018-04, Vol.32 (2), p.135-145

2018

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SGLT2 Inhibition by Dapagliflozin Attenuates Diabetic Ketoacidosis in Mice with Type-1 Diabetes

Cardiovascular drugs and therapy, 2022-12, Vol.36 (6), p.1091-1108

2022

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Phospholipase A2 and Its Role in Brain Tissue

Journal of neurochemistry, 1997-09, Vol.69 (3), p.889-901

1997

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Enzyme Technologies: Metagenomics, Evolution, Biocatalysis and Biosynthesis

1. Aufl., 2011

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Does des-acyl ghrelin improve glycemic control in obese diabetic subjects by decreasing acylated ghrelin levels?

European journal of endocrinology, 2014-06, Vol.170 (6), p.799-807

2014

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Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9807-9820

2017

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Enzyme Technologies: Pluripotent Players in Discovering Therapeutic Agent

1, 2013

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Design and synthesis of statine-containing BACE inhibitors

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (24), p.4335-4339

2003

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Response to inquiry by Gaylinn et al. on 'Administration of UAG improves glycemic control in obese subjects with diabetes'

European journal of endocrinology, 2015-07, Vol.173 (1), p.L3-L4

2015

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Biochemical and kinetic characterization of BACE1: investigation into the putative species‐specificity for β‐ and β′‐cleavage sites by human and murine BACE1

Journal of neurochemistry, 2004-12, Vol.91 (6), p.1249-1259

2004

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Group-Specific Assays That Distinguish between the Four Major Types of Mammalian Phospholipase A2

Analytical biochemistry, 1999-05, Vol.269 (2), p.278-288

1999

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A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization

Biochimica et biophysica acta, 1999-02, Vol.1437 (2), p.157-169

1999

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Enzyme technologies: pluripotent players in discovering therapeutic agents

2013

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Macrocyclic peptidomimetic inhibitors of β-secretase (BACE): First X-ray structure of a macrocyclic peptidomimetic-BACE complex

Bioorganic & medicinal chemistry letters, 2006, Vol.16 (1), p.191-195

2006

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Phe-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SAR

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.239-243

2004

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P3 cap modified Phe-Ala series BACE inhibitors

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.245-250

2004

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Dapagliflozin prevents abdominal visceral and subcutaneous adipose tissue dysfunction in the insulin‐resistant canine model

Obesity (Silver Spring, Md.), 2023-07, Vol.31 (7), p.1798-1811

2023

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1711-P: Dapagliflozin Promotes Adipose Beiging and Lipolysis and Reduces Adipocyte Size in the Obese Prediabetic Dog

Diabetes (New York, N.Y.), 2020-06, Vol.69 (Supplement_1)

2020

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Dapagliflozin Improves Insulin Sensitivity in the Obese Prediabetic Canine

Diabetes (New York, N.Y.), 2018-07, Vol.67 (Supplement_1)

2018

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Effects of sialic acid and sialoglycoconjugates on cytosolic phospholipases A2 from bovine brain

Biochemical and biophysical research communications, 1994-03, Vol.199 (3), p.1158-1166

1994

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Dapagliflozin and Ticagrelor Have Additive Effects on the Attenuation of the Activation of the NLRP3 Inflammasome and the Progression of Diabetic Cardiomyopathy: an AMPK–mTOR Interplay

Deriving functional human enteroendocrine cells from pluripotent stem cells

Differential In Vitro Effects of SGLT2 Inhibitors on Mitochondrial Oxidative Phosphorylation, Glucose Uptake and Cell Metabolism

Structural basis for GPR40 allosteric agonism and incretin stimulation

SGLT-2 Inhibition with Dapagliflozin Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Cardiomyopathy in Mice with Type 2 Diabetes. Further Augmentation of the Effects with Saxagliptin, a DPP4 Inhibitor

Combined SGLT2 and DPP4 Inhibition Reduces the Activation of the Nlrp3/ASC Inflammasome and Attenuates the Development of Diabetic Nephropathy in Mice with Type 2 Diabetes

SGLT2 Inhibition by Dapagliflozin Attenuates Diabetic Ketoacidosis in Mice with Type-1 Diabetes

Phospholipase A2 and Its Role in Brain Tissue

Enzyme Technologies: Metagenomics, Evolution, Biocatalysis and Biosynthesis

Does des-acyl ghrelin improve glycemic control in obese diabetic subjects by decreasing acylated ghrelin levels?

Optimization of Hydroxyethylamine Transition State Isosteres as Aspartic Protease Inhibitors by Exploiting Conformational Preferences

Enzyme Technologies: Pluripotent Players in Discovering Therapeutic Agent

Design and synthesis of statine-containing BACE inhibitors

Response to inquiry by Gaylinn et al. on 'Administration of UAG improves glycemic control in obese subjects with diabetes'

Biochemical and kinetic characterization of BACE1: investigation into the putative species‐specificity for β‐ and β′‐cleavage sites by human and murine BACE1

Group-Specific Assays That Distinguish between the Four Major Types of Mammalian Phospholipase A2

A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization

Enzyme technologies: pluripotent players in discovering therapeutic agents

Macrocyclic peptidomimetic inhibitors of β-secretase (BACE): First X-ray structure of a macrocyclic peptidomimetic-BACE complex

Phe-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SAR

P3 cap modified Phe-Ala series BACE inhibitors

Dapagliflozin prevents abdominal visceral and subcutaneous adipose tissue dysfunction in the insulin‐resistant canine model

1711-P: Dapagliflozin Promotes Adipose Beiging and Lipolysis and Reduces Adipocyte Size in the Obese Prediabetic Dog

Dapagliflozin Improves Insulin Sensitivity in the Obese Prediabetic Canine

Effects of sialic acid and sialoglycoconjugates on cytosolic phospholipases A2 from bovine brain

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