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Evaluation of the potential for drug-induced liver injury based on in vitro covalent binding to human liver proteins

Drug metabolism and disposition, 2009-12, Vol.37 (12), p.2383-2392

2009

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Species differences in hepatic and intestinal metabolic activities for 43 human cytochrome P450 substrates between humans and rats or dogs

Xenobiotica, 2013-11, Vol.43 (11), p.948-955

2013

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Prediction of the Intestinal First-pass Metabolism of CYP3A and UGT Substrates in Humans from in vitro Data

DRUG METABOLISM AND PHARMACOKINETICS, 2011-01, Vol.26 (6), p.592-601

2011

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Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug–drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys

Drug metabolism and pharmacokinetics, 2015-04, Vol.30 (2), p.198-204

2015

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Significance of reductive metabolism in human intestine and quantitative prediction of intestinal first-pass metabolism by cytosolic reductive enzymes

Drug metabolism and disposition, 2013-05, Vol.41 (5), p.1104-1111

2013

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Prediction of the intestinal first-pass metabolism of CYP3A substrates in humans using cynomolgus monkeys

Drug metabolism and disposition, 2010-11, Vol.38 (11), p.1967-1975

2010

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Species Differences in Intestinal Metabolic Activities of Cytochrome P450 isoforms between Cynomolgus Monkeys and Humans

DRUG METABOLISM AND PHARMACOKINETICS, 2011-01, Vol.26 (3), p.300-306

2011

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Investigation of inter-individual variation in pharmacokinetics in Sprague-Dawley rats: Possible involvement of aldehyde oxidase

Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S83-S84

2017

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A comparison of uptake of metformin and phenformin mediated by hOCT1 in human hepatocytes

Biopharmaceutics & drug disposition, 2009-11, Vol.30 (8), p.476-484

2009

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Transport of biguanides by human organic cation transporter OCT2

Biomedicine & pharmacotherapy, 2013-06, Vol.67 (5), p.425-430

2013

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Time-dependent inhibition (TDI) of CYP1A2 by a CYP3A4-mediated reactive metabolite: proposal for a novel mechanism of irreversible TDI by a non-suicide substrate

Xenobiotica, 2019-06, Vol.49 (6), p.636-645

2019

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Pharmacokinetics of miriplatin in experimental dog models of hepatic or renal impairment

European journal of drug metabolism and pharmacokinetics, 2011-12, Vol.36 (4), p.213-222

2011

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Retraction Note to: Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes

European journal of drug metabolism and pharmacokinetics, 2019-12, Vol.44 (6), p.853-853

2019

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Translational research into species differences of endocrine toxicity via steroidogenesis inhibition by SMP-028 — For human safety in clinical study

Toxicology and applied pharmacology, 2014-05, Vol.276 (3), p.213-219

2014

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Liver uptake of Biguanides in rats

Biomedicine & pharmacotherapy, 2011-09, Vol.65 (6), p.451-455

2011

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Effect of SMP-028 on steroidogenesis in rats; mechanism of toxicological events on endocrine organs of rats

Toxicology in vitro, 2014-04, Vol.28 (3), p.397-402

2014

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Blonanserin, a novel atypical antipsychotic agent not actively transported as substrate by P-glycoprotein

Progress in neuro-psychopharmacology & biological psychiatry, 2012-10, Vol.39 (1), p.156-162

2012

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Local Thrombus Formation in the Site of Intravenous Injection of Chlorpromazine : Possible Colloid-Osmotic Lysis of the Local Endothelial Cells

Biological and Pharmaceutical Bulletin, 2000/08/01, Vol.23(8), pp.957-961

2000

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A new methodology for simultaneous quantification of total-Aβ, Aβx-38, Aβx-40, and Aβx-42 by column-switching LC/MS/MS

Analytical and bioanalytical chemistry, 2012-02, Vol.402 (6), p.2033-2042

2012

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A new methodology for simultaneous quantification of total-A[beta], A[beta]x-38, A[beta]x-40, and A[beta]x-42 by column-switching LC/MS/MS

Analytical and bioanalytical chemistry, 2012-02, Vol.402 (6), p.2033

2012

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A new methodology for simultaneous quantification of total-A Delta b, A Delta bx-38, A Delta bx-40, and A Delta bx-42 by column-switching LC/MS/MS

Analytical and bioanalytical chemistry, 2012-02, Vol.402 (6), p.2033-2042

2012

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Development of relevant assay system to identify steroidogenic enzyme inhibitors

Toxicology in vitro, 2010-03, Vol.24 (2), p.677-685

2010

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Pharmacokinetics of a novelN-methyl-D-aspartate receptor antagonist (SM-18400): Identification of anN-acetylated metabolite and pre-clinical assessment ofN-acetylation polymorphism

European journal of drug metabolism and pharmacokinetics, 2003-03, Vol.28 (1), p.21-29

2003

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The new acyl-CoA cholesterol acyltransferase inhibitor SMP-797 does not interact with statins via OATP1B1 in human cryopreserved hepatocytes and oocytes expressing systems

Biopharmaceutics & drug disposition, 2007-12, Vol.28 (9), p.517-525

2007

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Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes

European journal of drug metabolism and pharmacokinetics, 2007-10, Vol.32 (4), p.233-240

2007

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Evaluation of the potential for drug-induced liver injury based on in vitro covalent binding to human liver proteins

Species differences in hepatic and intestinal metabolic activities for 43 human cytochrome P450 substrates between humans and rats or dogs

Prediction of the Intestinal First-pass Metabolism of CYP3A and UGT Substrates in Humans from in vitro Data

Dehydroepiandrosterone sulfate, a useful endogenous probe for evaluation of drug–drug interaction on hepatic organic anion transporting polypeptide (OATP) in cynomolgus monkeys

Significance of reductive metabolism in human intestine and quantitative prediction of intestinal first-pass metabolism by cytosolic reductive enzymes

Prediction of the intestinal first-pass metabolism of CYP3A substrates in humans using cynomolgus monkeys

Species Differences in Intestinal Metabolic Activities of Cytochrome P450 isoforms between Cynomolgus Monkeys and Humans

Investigation of inter-individual variation in pharmacokinetics in Sprague-Dawley rats: Possible involvement of aldehyde oxidase

A comparison of uptake of metformin and phenformin mediated by hOCT1 in human hepatocytes

Transport of biguanides by human organic cation transporter OCT2

Time-dependent inhibition (TDI) of CYP1A2 by a CYP3A4-mediated reactive metabolite: proposal for a novel mechanism of irreversible TDI by a non-suicide substrate

Pharmacokinetics of miriplatin in experimental dog models of hepatic or renal impairment

Retraction Note to: Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes

Translational research into species differences of endocrine toxicity via steroidogenesis inhibition by SMP-028 — For human safety in clinical study

Liver uptake of Biguanides in rats

Effect of SMP-028 on steroidogenesis in rats; mechanism of toxicological events on endocrine organs of rats

Blonanserin, a novel atypical antipsychotic agent not actively transported as substrate by P-glycoprotein

Local Thrombus Formation in the Site of Intravenous Injection of Chlorpromazine : Possible Colloid-Osmotic Lysis of the Local Endothelial Cells

A new methodology for simultaneous quantification of total-Aβ, Aβx-38, Aβx-40, and Aβx-42 by column-switching LC/MS/MS

A new methodology for simultaneous quantification of total-A[beta], A[beta]x-38, A[beta]x-40, and A[beta]x-42 by column-switching LC/MS/MS

A new methodology for simultaneous quantification of total-A Delta b, A Delta bx-38, A Delta bx-40, and A Delta bx-42 by column-switching LC/MS/MS

Development of relevant assay system to identify steroidogenic enzyme inhibitors

Pharmacokinetics of a novelN-methyl-D-aspartate receptor antagonist (SM-18400): Identification of anN-acetylated metabolite and pre-clinical assessment ofN-acetylation polymorphism

The new acyl-CoA cholesterol acyltransferase inhibitor SMP-797 does not interact with statins via OATP1B1 in human cryopreserved hepatocytes and oocytes expressing systems

Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes

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