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MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways

Science translational medicine, 2012-02, Vol.4 (121), p.121ra18

2012

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Pericyte TIMP3 and ADAMTS1 Modulate Vascular Stability after Kidney Injury

Journal of the American Society of Nephrology, 2012-05, Vol.23 (5), p.868-883

2012

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Dicer1 activity in the stromal compartment regulates nephron differentiation and vascular patterning during mammalian kidney organogenesis

Kidney international, 2015-06, Vol.87 (6), p.1125-1140

2015

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A Novel Mode of Action of the Putative Sphingosine Kinase Inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) Thiazole (SKI II): Induction of Lysosomal Sphingosine Kinase 1 Degradation

Cellular physiology and biochemistry, 2010-01, Vol.26 (1), p.97-104

2010

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Transforming growth factor-β2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-β2 by impeding CTGF expression

Kidney international, 2009-10, Vol.76 (8), p.857-867

2009

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STAT3 Protein-Protein Interaction Analysis Finds P300 as a Regulator of STAT3 and Histone 3 Lysine 27 Acetylation in Pericytes

Biomedicines, 2024-09, Vol.12 (9), p.2102

2024

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Impact of a young parabiotic circulation on renal injury and fibrosis in aged mice

The Lancet (British edition), 2016-02, Vol.387, p.S42-S42

2016

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Loss of sphingosine kinase‐1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin‐induced DNA damage

British journal of pharmacology, 2011-01, Vol.162 (2), p.532-543

2011

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Therapeutic silencing of SMOC2 prevents kidney function loss in mouse model of chronic kidney disease

iScience, 2021-10, Vol.24 (10), p.103193-103193, Article 103193

2021

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The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells

British journal of pharmacology, 2006-01, Vol.147 (2), p.164-174

2006

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Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways

The Journal of clinical investigation, 2015-01, Vol.125 (1), p.141-156

2015

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Mast cells link immune sensing to antigen-avoidance behaviour

Nature (London), 2023-08, Vol.620 (7974), p.634-642

2023

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Abstract 489: Unlocking immune resistance and metastasis of PDAC via dual acting circularized nanodisc

Cancer research (Chicago, Ill.), 2024-03, Vol.84 (6_Supplement), p.489-489

2024

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Heterologous desensitization of the sphingosine‐1‐phosphate receptors by purinoceptor activation in renal mesangial cells

British journal of pharmacology, 2004-11, Vol.143 (5), p.581-589

2004

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Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1β-induced prostaglandin E2 formation

Journal of lipid research, 2007-09, Vol.48 (9), p.1985-1996

2007

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Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis

Science translational medicine, 2023-05, Vol.15 (698), p.eabn0736

2023

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Interleukin‐1β inhibits ATP‐induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide

British journal of pharmacology, 2003-02, Vol.138 (3), p.461-468

2003

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Interleukin-1 inhibits angiotensin II-stimulated protein kinase B pathway in renal mesangial cells via the inducible nitric oxide synthase

European journal of pharmacology, 2002-05, Vol.442 (3), p.195-203

2002

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Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses

The Journal of biological chemistry, 2004-08, Vol.279 (34), p.35255-35262

2004

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Nitric Oxide Induces TIMP-1 Expression by Activating the Transforming Growth Factor β-Smad Signaling Pathway

The Journal of biological chemistry, 2005-11, Vol.280 (47), p.39403-39416

2005

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Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation

Journal of lipid research, 2007-09, Vol.48 (9), p.1985-1996

2007

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Transforming growth factor-[beta]2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-[beta]2 by impeding CTGF expression

Kidney international, 2009-10, Vol.76 (8), p.857

2009

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PPARα activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism

Biochemical and biophysical research communications, 2005-12, Vol.338 (4), p.1818-1824

2005

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Differential binding of ceramide to MEKK1 in glomerular endothelial and mesangial cells

Biochimica et biophysica acta, 2004-03, Vol.1636 (2), p.159-168

2004

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PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism

Biochemical and biophysical research communications, 2005-12, Vol.338 (4), p.1818

2005

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MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways

Pericyte TIMP3 and ADAMTS1 Modulate Vascular Stability after Kidney Injury

Dicer1 activity in the stromal compartment regulates nephron differentiation and vascular patterning during mammalian kidney organogenesis

A Novel Mode of Action of the Putative Sphingosine Kinase Inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) Thiazole (SKI II): Induction of Lysosomal Sphingosine Kinase 1 Degradation

Transforming growth factor-β2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-β2 by impeding CTGF expression

STAT3 Protein-Protein Interaction Analysis Finds P300 as a Regulator of STAT3 and Histone 3 Lysine 27 Acetylation in Pericytes

Impact of a young parabiotic circulation on renal injury and fibrosis in aged mice

Loss of sphingosine kinase‐1 in carcinoma cells increases formation of reactive oxygen species and sensitivity to doxorubicin‐induced DNA damage

Therapeutic silencing of SMOC2 prevents kidney function loss in mouse model of chronic kidney disease

The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells

Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways

Mast cells link immune sensing to antigen-avoidance behaviour

Abstract 489: Unlocking immune resistance and metastasis of PDAC via dual acting circularized nanodisc

Heterologous desensitization of the sphingosine‐1‐phosphate receptors by purinoceptor activation in renal mesangial cells

Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1β-induced prostaglandin E2 formation

Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis

Interleukin‐1β inhibits ATP‐induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide

Interleukin-1 inhibits angiotensin II-stimulated protein kinase B pathway in renal mesangial cells via the inducible nitric oxide synthase

Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses

Nitric Oxide Induces TIMP-1 Expression by Activating the Transforming Growth Factor β-Smad Signaling Pathway

Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation

Transforming growth factor-[beta]2 upregulates sphingosine kinase-1 activity, which in turn attenuates the fibrotic response to TGF-[beta]2 by impeding CTGF expression

PPARα activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism

Differential binding of ceramide to MEKK1 in glomerular endothelial and mesangial cells

PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism

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