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Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases

Journal of medicinal chemistry, 2021-02, Vol.64 (3), p.1283-1345

2021

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Design, synthesis and anticancer activities of novel dual poly(ADP-ribose) polymerase-1/histone deacetylase-1 inhibitors

Bioorganic & medicinal chemistry letters, 2020-04, Vol.30 (8), p.127036, Article 127036

2020

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Synthesis and biological evaluation of 6-fluoro-3-phenyl-7-piperazinyl quinolone derivatives as potential topoisomerase I inhibitors

European journal of medicinal chemistry, 2016-10, Vol.122, p.465-474

2016

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Discovery and Development of Cyclin-Dependent Kinase 8 Inhibitors

Current medicinal chemistry, 2020-01, Vol.27 (32), p.5429-5443

2020

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Identification of novel PARP-1 inhibitors: Drug design, synthesis and biological evaluation

Bioorganic & medicinal chemistry letters, 2015-10, Vol.25 (20), p.4557-4561

2015

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Lycopene inhibits carrageenan-induced thrombi by regulating AKT/FoxO3a and TLR4/NF-κB pathways

Journal of functional foods, 2024-02, Vol.113, p.106021, Article 106021

2024

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Design, synthesis, and biological evaluation of novel highly selective polo-like kinase 2 inhibitors based on the tetrahydropteridin chemical scaffold

European journal of medicinal chemistry, 2018-01, Vol.143, p.724-731

2018

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LongShengZhi capsule inhibits doxorubicin-induced heart failure by anti-oxidative stress

Biomedicine & pharmacotherapy, 2020-03, Vol.123, p.109803-109803, Article 109803

2020

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LX0702, a novel snake venom peptide derivative, inhibits thrombus formation via affecting the binding of fibrinogen with GPIIb/IIIa

Journal of pharmacological sciences, 2015-04, Vol.127 (4), p.462-466

2015

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Apigenin ameliorates imiquimod-induced psoriasis in C57BL/6J mice by inactivating STAT3 and NF-κB

Food Science and Human Wellness, 2024-01, Vol.13 (1), p.211-224

2024

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Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts

Journal of medicinal chemistry, 2022-05, Vol.65 (9), p.6356-6389

2022

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Discovery and development of plasma kallikrein inhibitors for multiple diseases

European journal of medicinal chemistry, 2020-03, Vol.190, p.112137-112137, Article 112137

2020

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Thiazole-based analogs as potential antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) and their SAR elucidation

European journal of medicinal chemistry, 2023-11, Vol.259, p.115689-115689, Article 115689

2023

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Factor XIa Inhibitors in Anticoagulation Therapy: Recent Advances and Perspectives

Journal of medicinal chemistry, 2023-04, Vol.66 (8), p.5332-5363

2023

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Zinc enzymes in medicinal chemistry

European journal of medicinal chemistry, 2021-12, Vol.226, p.113877-113877, Article 113877

2021

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Discovery of Polo-like Kinase 4 Inhibitors for the Treatment of Cancer: A Mini Patent Review

Mini reviews in medicinal chemistry, 2023, Vol.23 (1), p.67-79

2023

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Developing polo-like kinase 1 inhibitors

Future medicinal chemistry, 2020-05, Vol.12 (10), p.869-871

2020

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An Overview of Naphthylimide as Specific Scaffold for New Drug Discovery

Molecules (Basel, Switzerland), 2024-09, Vol.29 (19), p.4529

2024

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Design and synthesis of indoline thiohydantoin derivatives based on enzalutamide as antiproliferative agents against prostate cancer

European journal of medicinal chemistry, 2017-01, Vol.125, p.1002-1022

2017

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Progress with polo-like kinase (PLK) inhibitors: a patent review (2018-present)

Expert opinion on therapeutic patents, 2024-09, Vol.34 (9), p.789-806

2024

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In silico method and bioactivity evaluation to discover novel antimicrobial agents targeting FtsZ protein: Machine learning, virtual screening and antibacterial mechanism study

Naunyn-Schmiedeberg's archives of pharmacology, 2024-07

2024

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Discovery of Highly Selective, Potent, Covalent, and Orally Bioavailable Factor XIIa Inhibitors for the Treatment of Thrombo-Inflammation

Journal of medicinal chemistry, 2024-07, Vol.67 (13), p.10946-10966

2024

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Targeting the S2 Subsite Enables the Structure-Based Discovery of Novel Highly Selective Factor XIa Inhibitors

Journal of medicinal chemistry, 2022-03, Vol.65 (5), p.4318-4334

2022

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Novel 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as potent selective human monoamine oxidase B inhibitors: Design, SAR development, and biological evaluation

Bioorganic & medicinal chemistry letters, 2021-07, Vol.43, p.128051-128051, Article 128051

2021

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The selectivity and bioavailability improvement of novel oral anticoagulants: An overview

European journal of medicinal chemistry, 2018-02, Vol.146, p.299-317

2018

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Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases

Design, synthesis and anticancer activities of novel dual poly(ADP-ribose) polymerase-1/histone deacetylase-1 inhibitors

Synthesis and biological evaluation of 6-fluoro-3-phenyl-7-piperazinyl quinolone derivatives as potential topoisomerase I inhibitors

Discovery and Development of Cyclin-Dependent Kinase 8 Inhibitors

Identification of novel PARP-1 inhibitors: Drug design, synthesis and biological evaluation

Lycopene inhibits carrageenan-induced thrombi by regulating AKT/FoxO3a and TLR4/NF-κB pathways

Design, synthesis, and biological evaluation of novel highly selective polo-like kinase 2 inhibitors based on the tetrahydropteridin chemical scaffold

LongShengZhi capsule inhibits doxorubicin-induced heart failure by anti-oxidative stress

LX0702, a novel snake venom peptide derivative, inhibits thrombus formation via affecting the binding of fibrinogen with GPIIb/IIIa

Apigenin ameliorates imiquimod-induced psoriasis in C57BL/6J mice by inactivating STAT3 and NF-κB

Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts

Discovery and development of plasma kallikrein inhibitors for multiple diseases

Thiazole-based analogs as potential antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) and their SAR elucidation

Factor XIa Inhibitors in Anticoagulation Therapy: Recent Advances and Perspectives

Zinc enzymes in medicinal chemistry

Discovery of Polo-like Kinase 4 Inhibitors for the Treatment of Cancer: A Mini Patent Review

Developing polo-like kinase 1 inhibitors

An Overview of Naphthylimide as Specific Scaffold for New Drug Discovery

Design and synthesis of indoline thiohydantoin derivatives based on enzalutamide as antiproliferative agents against prostate cancer

Progress with polo-like kinase (PLK) inhibitors: a patent review (2018-present)

In silico method and bioactivity evaluation to discover novel antimicrobial agents targeting FtsZ protein: Machine learning, virtual screening and antibacterial mechanism study

Discovery of Highly Selective, Potent, Covalent, and Orally Bioavailable Factor XIIa Inhibitors for the Treatment of Thrombo-Inflammation

Targeting the S2 Subsite Enables the Structure-Based Discovery of Novel Highly Selective Factor XIa Inhibitors

Novel 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as potent selective human monoamine oxidase B inhibitors: Design, SAR development, and biological evaluation

The selectivity and bioavailability improvement of novel oral anticoagulants: An overview

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