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Structure basis for RNA-guided DNA degradation by Cascade and Cas3

Science (American Association for the Advancement of Science), 2018-07, Vol.361 (6397)

2018

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Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System

Cell, 2017-06, Vol.170 (1), p.48-60.e11

2017

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Introducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas

Molecular cell, 2019-06, Vol.74 (5), p.936-950.e5

2019

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Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli

Nature (London), 2016-02, Vol.530 (7591), p.499-503

2016

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Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer

Nature communications, 2022-05, Vol.13 (1), p.2903-2903, Article 2903

2022

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Real-time observation of CRISPR spacer acquisition by Cas1-Cas2 integrase

Nature structural & molecular biology, 2020-05, Vol.27 (5), p.489-499

2020

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Mechanistic insights into lanthipeptide modification by a distinct subclass of LanKC enzyme that forms dimers

Nature communications, 2024-08, Vol.15 (1), p.7090-20

2024

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Structure and genome editing of type I-B CRISPR-Cas

Nature communications, 2024-05, Vol.15 (1), p.4126-4126, Article 4126

2024

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Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex

Cell, 2018-11, Vol.175 (4), p.934-946.e15

2018

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Novel Inhibitors of 2'- O -Methyltransferase of the SARS-CoV-2 Coronavirus

Molecules (Basel, Switzerland), 2022-04, Vol.27 (9), p.2721

2022

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Massively Parallel Biophysical Analysis of CRISPR-Cas Complexes on Next Generation Sequencing Chips

Cell, 2017-06, Vol.170 (1), p.35-47.e13

2017

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Precise Gene Knock‐In Tools with Minimized Risk of DSBs: A Trend for Gene Manipulation

Advanced science, 2024-07, Vol.11 (28), p.e2401797-n/a

2024

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Mechanistic insights into transposon cleavage and integration by TnsB of ShCAST system

Cell reports (Cambridge), 2023-07, Vol.42 (7), p.112698-112698, Article 112698

2023

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Nonstructural Proteins 7 and 8 of Feline Coronavirus Form a 2:1 Heterotrimer That Exhibits Primer-Independent RNA Polymerase Activity

Journal of Virology, 2012-04, Vol.86 (8), p.4444-4454

2012

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Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation

Cell reports (Cambridge), 2023-11, Vol.42 (11), p.113417-113417, Article 113417

2023

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AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma

Journal of experimental & clinical cancer research, 2022-01, Vol.41 (1), p.11-14, Article 11

2022

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Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents

Acta pharmaceutica Sinica. B, 2022-12, Vol.12 (12), p.4446-4457

2022

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Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis

Acta pharmaceutica Sinica. B, 2024-02, Vol.14 (2), p.869-880

2024

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Correction: AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma

Journal of experimental & clinical cancer research, 2023-04, Vol.42 (1), p.91-91, Article 91

2023

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Repurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV)

Communications biology, 2024-07, Vol.7 (1), p.858-12, Article 858

2024

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PIWI Takes a Giant Step

Cell, 2016-10, Vol.167 (2), p.310-312

2016

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Reconstitution and biochemical characterization of ribonucleoprotein complexes in Type I-E CRISPR-Cas systems

Methods in enzymology, 2019-01, Vol.616, p.27-41

2019

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How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration

Nature (London), 2017-10, Vol.550 (7674), p.137-141

2017

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Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems

Molecular cell, 2022-02, Vol.82 (4), p.852-867.e5

2022

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Discovery of 4′-O-methylscutellarein as a potent SARS-CoV-2 main protease inhibitor

Biochemical and biophysical research communications, 2022-05, Vol.604, p.76-82

2022

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Structure basis for RNA-guided DNA degradation by Cascade and Cas3

Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System

Introducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas

Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli

Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer

Real-time observation of CRISPR spacer acquisition by Cas1-Cas2 integrase

Mechanistic insights into lanthipeptide modification by a distinct subclass of LanKC enzyme that forms dimers

Structure and genome editing of type I-B CRISPR-Cas

Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex

Novel Inhibitors of 2'- O -Methyltransferase of the SARS-CoV-2 Coronavirus

Massively Parallel Biophysical Analysis of CRISPR-Cas Complexes on Next Generation Sequencing Chips

Precise Gene Knock‐In Tools with Minimized Risk of DSBs: A Trend for Gene Manipulation

Mechanistic insights into transposon cleavage and integration by TnsB of ShCAST system

Nonstructural Proteins 7 and 8 of Feline Coronavirus Form a 2:1 Heterotrimer That Exhibits Primer-Independent RNA Polymerase Activity

Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation

AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma

Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents

Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis

Correction: AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma

Repurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV)

PIWI Takes a Giant Step

Reconstitution and biochemical characterization of ribonucleoprotein complexes in Type I-E CRISPR-Cas systems

How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration

Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems

Discovery of 4′-O-methylscutellarein as a potent SARS-CoV-2 main protease inhibitor

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