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Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction

Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (4), p.1196-1201

2015

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Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity

Biological psychiatry (1969), 2013-03, Vol.73 (6), p.501-509

2013

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mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning

Neuropsychopharmacology (New York, N.Y.), 2009-08, Vol.34 (9), p.2057-2071

2009

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M4 mAChR-Mediated Modulation of Glutamatergic Transmission at Corticostriatal Synapses

ACS chemical neuroscience, 2014-04, Vol.5 (4), p.318-324

2014

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M 1 muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons

Neuropharmacology, 2017-05, Vol.118, p.209-222

2017

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Allosteric activation of M₄ muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice

Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (45), p.14078-14083

2015

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A Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 2 Blocks a Hallucinogenic Drug Model of Psychosis

Molecular pharmacology, 2007-08, Vol.72 (2), p.477-484

2007

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Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Molecular pharmacology, 2008-11, Vol.74 (5), p.1345-1358

2008

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An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission

Nature chemical biology, 2008, Vol.4 (1), p.42-50

2008

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A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 Antagonist Reduces Seizures without Impairing Hippocampus-Dependent Learning

Molecular pharmacology, 2009-08, Vol.76 (2), p.356-368

2009

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Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata

Neuroscience letters, 2011-10, Vol.504 (2), p.102-106

2011

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Cholinergic Switching Within Neocortical Inhibitory Networks

Science (American Association for the Advancement of Science), 1998-08, Vol.281 (5379), p.985-988

1998

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Antipsychotic-like Effects of M 4 Positive Allosteric Modulators Are Mediated by CB 2 Receptor-Dependent Inhibition of Dopamine Release

Neuron (Cambridge, Mass.), 2016-09, Vol.91 (6), p.1244-1252

2016

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The Role of mGlu Receptors in Hippocampal Plasticity Deficits in Neurological and Psychiatric Disorders: Implications for Allosteric Modulators as Novel Therapeutic Strategies

Current neuropharmacology, 2016-07, Vol.14 (5), p.455-473

2016

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Modulation of Spontaneous Firing in Rat Subthalamic Neurons by 5-HT Receptor Subtypes

Journal of neurophysiology, 2005-03, Vol.93 (3), p.1145-1157

2005

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Activity-Dependent Bidirectional Modification of Inhibitory Synaptic Transmission in Rat Subthalamic Neurons

The Journal of neuroscience, 2006-07, Vol.26 (28), p.7321-7327

2006

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Synaptic Inhibition of Pyramidal Cells Evoked by Different Interneuronal Subtypes in Layer V of Rat Visual Cortex

Journal of neurophysiology, 2002-08, Vol.88 (2), p.740-750

2002

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Development of a highly selective, orally bioavailable and CNS penetrant M₁ agonist derived from the MLPCN probe ML071

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (21), p.6451-6455

2011

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Ultrasound neuromodulation depends on pulse repetition frequency and can modulate inhibitory effects of TTX

Scientific reports, 2020-09, Vol.10 (1), p.15347, Article 15347

2020

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Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral Deficits

Biological psychiatry (1969), 2024-08, Vol.96 (3), p.230-242

2024

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Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus

Biological psychiatry (1969), 2021-09, Vol.90 (6), p.385-398

2021

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Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons

Neuron (Cambridge, Mass.), 2022-03, Vol.110 (6), p.1068-1083.e5

2022

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Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release

Neuron (Cambridge, Mass.), 2016-09, Vol.91 (6), p.1244-1252

2016

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M 1 -positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition

Neuropsychopharmacology (New York, N.Y.), 2018-07, Vol.43 (8), p.1763

2018

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M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition

Neuropsychopharmacology (New York, N.Y.), 2018-07, Vol.43 (8), p.1763-1771

2018

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Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction

Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity

mGluR5 Positive Allosteric Modulators Facilitate both Hippocampal LTP and LTD and Enhance Spatial Learning

M4 mAChR-Mediated Modulation of Glutamatergic Transmission at Corticostriatal Synapses

M 1 muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons

Allosteric activation of M₄ muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice

A Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 2 Blocks a Hallucinogenic Drug Model of Psychosis

Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission

A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 Antagonist Reduces Seizures without Impairing Hippocampus-Dependent Learning

Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata

Cholinergic Switching Within Neocortical Inhibitory Networks

Antipsychotic-like Effects of M 4 Positive Allosteric Modulators Are Mediated by CB 2 Receptor-Dependent Inhibition of Dopamine Release

The Role of mGlu Receptors in Hippocampal Plasticity Deficits in Neurological and Psychiatric Disorders: Implications for Allosteric Modulators as Novel Therapeutic Strategies

Modulation of Spontaneous Firing in Rat Subthalamic Neurons by 5-HT Receptor Subtypes

Activity-Dependent Bidirectional Modification of Inhibitory Synaptic Transmission in Rat Subthalamic Neurons

Synaptic Inhibition of Pyramidal Cells Evoked by Different Interneuronal Subtypes in Layer V of Rat Visual Cortex

Development of a highly selective, orally bioavailable and CNS penetrant M₁ agonist derived from the MLPCN probe ML071

Ultrasound neuromodulation depends on pulse repetition frequency and can modulate inhibitory effects of TTX

Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral Deficits

Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus

Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons

Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release

M 1 -positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition

M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition

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