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Increased PARP1‐DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1‐DNA trapping is correlated with PARP1 inhibitor's cytotoxicity

International journal of cancer, 2019-08, Vol.145 (3), p.714-727

2019

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Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance

EMBO molecular medicine, 2023-03, Vol.15 (3), p.e16235-n/a

2023

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Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer

Cell death & disease, 2021-02, Vol.12 (2), p.183-18, Article 183

2021

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SOMCL-19-133, a novel, selective, and orally available inhibitor of NEDD8-activating enzyme (NAE) for cancer therapy

Neoplasia (New York, N.Y.), 2022-10, Vol.32, p.100823-100823, Article 100823

2022

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Cytotoxic Nitrogenous Terpenoids from Two South China Sea Nudibranchs Phyllidiella pustulosa , Phyllidia coelestis , and Their Sponge-Prey Acanthella cavernosa

Marine drugs, 2019-01, Vol.17 (1), p.56

2019

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Polyoxygenated Cembranoids from Soft Coral Lobophytum Crassum and Their Anti‐tumoral Activities

Chinese journal of chemistry, 2021-03, Vol.39 (3), p.640-646

2021

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Chemical constituents from the South China sea soft coral Sinularia humilis

Natural product research, 2022-07, Vol.36 (13), p.3324-3330

2022

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Inhibition of the BET family reduces its new target gene IDO1 expression and the production of l-kynurenine

Cell death & disease, 2019-07, Vol.10 (8), p.557-13, Article 557

2019

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Uncommon Bis‐quinolizidine Alkaloids from the Hainan Sponge Neopetrosia chaliniformis

Chinese journal of chemistry, 2021-07, Vol.39 (7), p.1838-1842

2021

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A new bis-γ-pyrone polypropionate of onchidiol family from marine pulmonate mollusk Onchidium sp

Natural product research, 2020-07, Vol.34 (14), p.1971-1976

2020

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A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction

Investigational new drugs, 2020-06, Vol.38 (3), p.700-713

2020

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Lagerindicine, a New Pyrrole Alkaloid Isolated from the Flowers of Lagerstroemia indica Linnaeus

Natural products and bioprospecting, 2021-02, Vol.11 (1), p.73-79

2021

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Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy

Biochemical pharmacology, 2024-05, Vol.223, p.116198, Article 116198

2024

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Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non-Small Cell Lung Cancer Cells

Molecular cancer research, 2022-12, Vol.20 (12), p.1785-1798

2022

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The combination of methionine adenosyltransferase 2A inhibitor and methyltransferase like 3 inhibitor promotes apoptosis of non-small cell lung cancer cells and produces synergistic anti-tumor activity

Biochemical and biophysical research communications, 2024-07, Vol.716, p.150011, Article 150011

2024

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Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors

Bioorganic & medicinal chemistry letters, 2021-01, Vol.31, p.127710-127710, Article 127710

2021

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Structure-Based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein Inhibitors

Journal of medicinal chemistry, 2019-09, Vol.62 (18), p.8642-8663

2019

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Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta

Steroids, 2020-09, Vol.161, p.108681-108681, Article 108681

2020

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Triptolide Induces Cell Killing in Multidrug-Resistant Tumor Cells via CDK7/RPB1 Rather than XPB or p44

Molecular cancer therapeutics, 2016-07, Vol.15 (7), p.1495-1503

2016

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Proteasome inhibitors reduce CD73 expression partly via decreasing p-ERK in NSCLC cells

Life sciences (1973), 2023-11, Vol.332, p.122129-122129, Article 122129

2023

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Novel bivalent BET inhibitor N2817 exhibits potent anticancer activity and inhibits TAF1

Biochemical pharmacology, 2021-03, Vol.185, p.114435, Article 114435

2021

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Design, Synthesis, and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)‑ones Bearing a Functionalized Longer Chain Appendage as Novel PARP1 Inhibitors

Journal of medicinal chemistry, 2013-04, Vol.56 (7), p.2885-2903

2013

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Two new hydroperoxy steroids from the South China Sea gorgonian Rumphella sp

Steroids, 2020-03, Vol.155, p.108558-108558, Article 108558

2020

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New cytotoxic ergostane-type sterols from the Chinese soft coral Sinularia sp

Steroids, 2019-09, Vol.149, p.108425-108425, Article 108425

2019

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Absorption, distribution, metabolism, and excretion of [14C]Mefuparib (CVL218), a novel PARP1/2 inhibitor, in rats

Cancer chemotherapy and pharmacology, 2022-12, Vol.90 (6), p.499-510

2022

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Increased PARP1‐DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1‐DNA trapping is correlated with PARP1 inhibitor's cytotoxicity

Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance

Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer

SOMCL-19-133, a novel, selective, and orally available inhibitor of NEDD8-activating enzyme (NAE) for cancer therapy

Cytotoxic Nitrogenous Terpenoids from Two South China Sea Nudibranchs Phyllidiella pustulosa , Phyllidia coelestis , and Their Sponge-Prey Acanthella cavernosa

Polyoxygenated Cembranoids from Soft Coral Lobophytum Crassum and Their Anti‐tumoral Activities

Chemical constituents from the South China sea soft coral Sinularia humilis

Inhibition of the BET family reduces its new target gene IDO1 expression and the production of l-kynurenine

Uncommon Bis‐quinolizidine Alkaloids from the Hainan Sponge Neopetrosia chaliniformis

A new bis-γ-pyrone polypropionate of onchidiol family from marine pulmonate mollusk Onchidium sp

A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction

Lagerindicine, a New Pyrrole Alkaloid Isolated from the Flowers of Lagerstroemia indica Linnaeus

Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy

Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non-Small Cell Lung Cancer Cells

The combination of methionine adenosyltransferase 2A inhibitor and methyltransferase like 3 inhibitor promotes apoptosis of non-small cell lung cancer cells and produces synergistic anti-tumor activity

Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors

Structure-Based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein Inhibitors

Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta

Triptolide Induces Cell Killing in Multidrug-Resistant Tumor Cells via CDK7/RPB1 Rather than XPB or p44

Proteasome inhibitors reduce CD73 expression partly via decreasing p-ERK in NSCLC cells

Novel bivalent BET inhibitor N2817 exhibits potent anticancer activity and inhibits TAF1

Design, Synthesis, and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)‑ones Bearing a Functionalized Longer Chain Appendage as Novel PARP1 Inhibitors

Two new hydroperoxy steroids from the South China Sea gorgonian Rumphella sp

New cytotoxic ergostane-type sterols from the Chinese soft coral Sinularia sp

Absorption, distribution, metabolism, and excretion of [14C]Mefuparib (CVL218), a novel PARP1/2 inhibitor, in rats

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