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Calcium Signaling and Cardiac Arrhythmias

Circulation research, 2017-06, Vol.120 (12), p.1969-1993

2017

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Enhanced Sarcoplasmic Reticulum Ca2+ Leak and Increased Na+-Ca2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation

Circulation (New York, N.Y.), 2012-05, Vol.125 (17), p.2059-2070

2012

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Circadian rhythms govern cardiac repolarization and arrhythmogenesis

Nature (London), 2012-02, Vol.483 (7387), p.96-99

2012

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Mutation E169K in Junctophilin-2 Causes Atrial Fibrillation Due to Impaired RyR2 Stabilization

Journal of the American College of Cardiology, 2013-11, Vol.62 (21), p.2010-2019

2013

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Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte Transverse-Tubule Remodeling and Ca2+ Handling Dysfunction in Heart Failure

Circulation (New York, N.Y.), 2014-04, Vol.129 (17), p.1742-1750

2014

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Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death

Proceedings of the National Academy of Sciences - PNAS, 2016-08, Vol.113 (33), p.E4895-E4903

2016

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Disrupted Junctional Membrane Complexes and Hyperactive Ryanodine Receptors After Acute Junctophilin Knockdown in Mice

Circulation (New York, N.Y.), 2011-03, Vol.123 (9), p.979-988

2011

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Ryanodine Receptor Phosphorylation by Calcium/Calmodulin-Dependent Protein Kinase II Promotes Life-Threatening Ventricular Arrhythmias in Mice With Heart Failure

Circulation (New York, N.Y.), 2010-12, Vol.122 (25), p.2669-2679

2010

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An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor

Science translational medicine, 2023-06, Vol.15 (701), p.eabq7839

2023

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Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1

Human molecular genetics, 2010-03, Vol.19 (6), p.1066-1075

2010

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Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients With Paroxysmal Atrial Fibrillation

Circulation (New York, N.Y.), 2014-01, Vol.129 (2), p.145-156

2014

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Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance

PloS one, 2013-03, Vol.8 (3), p.e58655-e58655

2013

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NODAL variants are associated with a continuum of laterality defects from simple D-transposition of the great arteries to heterotaxy

Genome medicine, 2024-04, Vol.16 (1), p.53-20, Article 53

2024

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Protection from Cardiac Arrhythmia through Ryanodine Receptor-Stabilizing Protein Calstabin2

Science (American Association for the Advancement of Science), 2004-04, Vol.304 (5668), p.292-296

2004

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Genome Editing and Cardiac Arrhythmias

Cells (Basel, Switzerland), 2023-05, Vol.12 (10), p.1363

2023

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Ryanodine Receptor/Calcium Release Channel PKA Phosphorylation: A Critical Mediator of Heart Failure Progression

Proceedings of the National Academy of Sciences - PNAS, 2006-01, Vol.103 (3), p.511-518

2006

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Defects in Ankyrin-Based Membrane Protein Targeting Pathways Underlie Atrial Fibrillation

Circulation (New York, N.Y.), 2011-09, Vol.124 (11), p.1212-1222

2011

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SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice

PloS one, 2016-12, Vol.11 (12), p.e0168644-e0168644

2016

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Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation

Journal of applied physiology (1985), 2009-04, Vol.106 (4), p.1280-1292

2009

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Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure

eLife, 2022-08, Vol.11

2022

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Impact of Noncardiac Comorbidities on Morbidity and Mortality in a Predominantly Male Population With Heart Failure and Preserved Versus Reduced Ejection Fraction

Journal of the American College of Cardiology, 2012-03, Vol.59 (11), p.998-1005

2012

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Stabilization of Cardiac Ryanodine Receptor Prevents Intracellular Calcium Leak and Arrhythmias

Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (20), p.7906-7910

2006

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Ryanodine Receptor–Mediated Calcium Leak Drives Progressive Development of an Atrial Fibrillation Substrate in a Transgenic Mouse Model

Circulation (New York, N.Y.), 2014-03, Vol.129 (12), p.1276-1285

2014

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Mouse Models of Cardiac Arrhythmias

Circulation research, 2018-07, Vol.123 (3), p.332-334

2018

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Mechanisms underlying pathological Ca2+ handling in diseases of the heart

Pflügers Archiv, 2021-03, Vol.473 (3), p.331-347

2021

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Calcium Signaling and Cardiac Arrhythmias

Enhanced Sarcoplasmic Reticulum Ca2+ Leak and Increased Na+-Ca2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation

Circadian rhythms govern cardiac repolarization and arrhythmogenesis

Mutation E169K in Junctophilin-2 Causes Atrial Fibrillation Due to Impaired RyR2 Stabilization

Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte Transverse-Tubule Remodeling and Ca2+ Handling Dysfunction in Heart Failure

Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death

Disrupted Junctional Membrane Complexes and Hyperactive Ryanodine Receptors After Acute Junctophilin Knockdown in Mice

Ryanodine Receptor Phosphorylation by Calcium/Calmodulin-Dependent Protein Kinase II Promotes Life-Threatening Ventricular Arrhythmias in Mice With Heart Failure

An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor

Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1

Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients With Paroxysmal Atrial Fibrillation

Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance

NODAL variants are associated with a continuum of laterality defects from simple D-transposition of the great arteries to heterotaxy

Protection from Cardiac Arrhythmia through Ryanodine Receptor-Stabilizing Protein Calstabin2

Genome Editing and Cardiac Arrhythmias

Ryanodine Receptor/Calcium Release Channel PKA Phosphorylation: A Critical Mediator of Heart Failure Progression

Defects in Ankyrin-Based Membrane Protein Targeting Pathways Underlie Atrial Fibrillation

SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice

Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation

Prolonged β-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure

Impact of Noncardiac Comorbidities on Morbidity and Mortality in a Predominantly Male Population With Heart Failure and Preserved Versus Reduced Ejection Fraction

Stabilization of Cardiac Ryanodine Receptor Prevents Intracellular Calcium Leak and Arrhythmias

Ryanodine Receptor–Mediated Calcium Leak Drives Progressive Development of an Atrial Fibrillation Substrate in a Transgenic Mouse Model

Mouse Models of Cardiac Arrhythmias

Mechanisms underlying pathological Ca2+ handling in diseases of the heart

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